The Rabbit Anti-Aggrecan/AGC1 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ACAN, and Aggrecan. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-Aggrecan/AGC1 Antibody has been shown to work in the following applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Aggrecan or aggregating chondroitin sulfate proteoglycan, is an integral part of the extracellular matrix in cartilagenous tissue. Many individual monomers of aggrecan bind to hyaluronic acid to form an aggregate, the monomer is known as aggrecan. The aggregates are comprised of up to 100 monomers attached to a single chain of hyaluronic acid. The high content of negatively charged polysaccharide chains contributes to the osmotic swelling of cartilage and in combination with intact collagen fibers results in articular cartilage resistance to compressive forces and high tensile strength. Aggrecan is abundant in articular cartilage and compromises 10% of its dry weight. The cleavage of Aggrecan has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration