The Rabbit Anti-Transferrin Receptor Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to TFRC, and transferrin receptor. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-Transferrin Receptor Antibody has been shown to work in the following applications: Flow Cytometry, Immunohistochemistry, and Immunoprecipitation.
Description
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site