The Rabbit Anti-hnRNP C1/C2 Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to heterogeneous nuclear ribonucleoprotein C (HNRNPC). This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-hnRNP C1/C2 Antibody has been shown to work in the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed: 8264621). Specifically recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non- coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch' to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed: 25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre- mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'- UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed: 12509468, PubMed: 16010978, PubMed: 7567451, PubMed: 8264621)