MyBioSource.com's Rabbit Anti-NEFA/NUCB2 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot. The Rabbit Anti-NEFA/NUCB2 Antibody was generated using Nucb2, and nucleobindin 2 as the antigen and it reacts with Mouse, and Rat.
Description
NEFA, a 420 amino acid protein (also known as NUCB2, nucleobindin 2, p54), is a DNA-binding protein localizing in the Golgi Apparatus. This protein has been implicated in various functions, including Ca2+ homeostasis, hypothalamic regulation of feeding and TNF-receptor-1 (TNFR1) shedding. NUCB2 has been shown to interact with both necdin and ARTS-1, both through the EF-hand motif. The NUCB2-ARTS-1 complex is required for the proteolytic cleavage and release of TNFR1 to the extracellular compartment. NUCB2 has been identified as a novel satiety molecule in the hypothalamous associated with melanocortin signaling in the central nervous system.NUCB2 and its N-terminal 82-amino acid cleavage fragment, termed nesfatin-1, have been shown to induce suppression of food-intake in rats