MyBioSource.com's MeCP2 Antibody is a Mouse monoclonal antibody. The MeCP2 Antibody was generated using MECP2, and methyl-CpG binding protein 2 as the antigen. It reacts with Mouse, and Rat. This antibody has been shown to work in applications such as: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females