The Rabbit Anti-PI 3 Kinase p85 alpha Antibody from MyBioSource.com is a Rabbit Monoclonal antibody to PIK3R1. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-PI 3 Kinase p85 alpha Antibody has been shown to work in the following applications: Western Blot.
Description
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed: 17626883, PubMed: 19805105, PubMed: 7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed: 20348923)