The Anti-RANK Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TNFRSF11A. This antibody recognizes Human, and Rat antigen. The Anti-RANK Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Description: Receptor Activator of Nuclear Factor kappa B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. It is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, this gene is mapped to 18q22.1.
Protein Function: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells