MyBioSource.com's Rabbit anti Pdia 4 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot. The Rabbit anti Pdia 4 Polyclonal Antibody was generated using PDIA4 as the antigen and it reacts with Human, Mouse, Rat, Bovine, and Canine.
Description
Protein Disulfide Isomerase A4 (PDIA4 or ERp72), a 645aa protein, is an endoplasmic reticulum luminal protein that responds to stress. Sequence analysis shows that it shares sequence identity with PDI (protein disulphide isomerase) at three discrete regions, as well as containing the ER retention signal KEEL at its C-terminus. ERp72 is shown to have three copies of sequence believed to be CGHC-containing active sites, which are also found in PDI. These CGHC sites are critical sites that are involved in the protein disulphide isomerization process. These results suggest that ERp72 is a newly described member of the family of CGHC-containing proteins that functions as a molecular chaperone