MyBioSource.com's Rabbit Anti-SUMO-2/Sentrin-2 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, Immunoprecipitation, and Western Blot. The Rabbit Anti-SUMO-2/Sentrin-2 Antibody was generated using SUMO2 as the antigen and it reacts with Human.
Description
Sentrin-2 also known as SUMO-2 is a 95-amino acids peptide that has high homologous to Sentrin-1/SUMO-1. This novel ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins