MyBioSource.com's Anti-LC3B Rabbit Monoclonal Antibody is a Rabbit monoclonal antibody. The Anti-LC3B Rabbit Monoclonal Antibody was generated using MAP1LC3B as the antigen. It reacts with Human, Mouse, and Rat. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway