MyBioSource.com's Anti-NOTCH4 Rabbit Monoclonal Antibody is a Rabbit monoclonal antibody. The Anti-NOTCH4 Rabbit Monoclonal Antibody was generated using Notch 4, and NOTCH4 as the antigen. It reacts with Human, and Mouse. This antibody has been shown to work in applications such as: Flow Cytometry, and Western Blot.
Description
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity)