MyBioSource.com's Anti-Brk Antibody is a Mouse monoclonal antibody. The Anti-Brk Antibody was generated using PTK6 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Immunoprecipitation, and Western Blot.
Description
Entrez Summary: The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniPort Summary Function: Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins