The Rabbit Anti-Fibrinogen Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to FGG, and fibrinogen gamma chain. This antibody recognizes Human, and Mouse antigen. The Rabbit Anti-Fibrinogen Antibody has been shown to work in the following applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
FGG, A 437 aa protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of non-identical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms, gamma-A is the predominant, shorter but has distinct C-term compared to gamma-B