The PLXNB2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Plexin B2, and PLXNB2. This antibody recognizes Human, and Mouse antigen. The PLXNB2 Antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity)