MyBioSource.com's WTAP Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot. The WTAP Antibody was generated using WTAP as the antigen and it reacts with Human, Mouse, and Rat.
Description
Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed: 24316715, PubMed: 24407421, PubMed: 24981863). Acts as a mRNA splicing regulator (PubMed: 12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed: 17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed: 17095724)