The Rabbit Anti-HIF, alpha Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to HIF1A. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-HIF, alpha Antibody has been shown to work in the following applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha) contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a transcription factor involved in mammalian oxygen homeostasis., HIF-1 is a heterodimer composed of HIF-1 alpha/beta subunits which binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation, and increase transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the hypoxic cells. In contrast, HIF-1 beta remains stable under either condition