The CAND1 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CAND1. This antibody recognizes Human, Mouse, and Rat antigen. The CAND1 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants