The Rabbit Anti-Catenin-b Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to catenin beta 1, and CTNNB1. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit Anti-Catenin-b Antibody has been shown to work in the following applications: ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, and Western Blot.
Description
Beta-catenin, a cytosolic, 88 kDa, 781 amino acid protein, belongs to the beta-catenin family. The N-terminus domain, contains the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin (s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors, initiating gene expression. Normally, beta-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3beta and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates beta-catenin at multiple sites, including S33 and S37, Y96, Y228, Y280, S675, etc. Phosphorylation of beta-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3beta activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3beta, allowing unphosphorylated beta-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis