Mouse IgG2B Isotype Control MAB004 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse IgG2B Isotype Control
CompanyR&D Systems, a Bio-Techne Brand
Price $249.00Supplier Page View Company Product Page
Catalog NumberMAB004
Quantity500 ug
ApplicationsControl
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose
ConcentrationLYOPH
PurityProtein A or G purified from hybridoma culture supernatant
TargetIgG2B
ReactivityMouse
IsotypeIgG2b
Clone20116
HostMouse
Antibody TypeIsotype Controls
ImmunogenKLH
ClonalityMonoclonal
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Molecular Boolean analyses of chemokine (C–C motif) receptor 1, α1B-adrenoceptor and arginine vasopressin receptor 1A heteromersBiochemistry and Biophysics ReportsMarch 1, 2026Xianlong Gao, Matthias Majetschak(hVSMCs) [9,11,12]. 2 Materials and methods 2.1 Materials Mouse anti-CCR1 (MAB145), mouse IgG (MAB004) and rabbit IgG (MAB1050) were purchased from R&D Systems (Minneapolis, MN, USA). Rabbit anti-α1B-AR

(2) LDB1 represses fetal hemoglobin expression by enhancing BCL11A transcriptionRedox BiolFebruary 4, 2026Si-Won Park, Chang-Yong Choi, In-Byung Park, Seok-Jin Kang, Hyeon Jeong Lee, Ji-In Kim, Joonbeom Bae, Dongho Geum, Yong-Pil Cheon, Taehoon ChunAbs per sample: anti-LDB1 (Santa Cruz Biotechnology sc-365074) and its isotype control (R&D Systems MAB004), anti-GATA1 (Santa Cruz Biotechnology sc-265) and its isotype control (Santa Cruz Biotechnology, Inc.

(3) NOX4-derived oxidative DNA damage impairs thyroid differentiation through an epigenetic mechanism in BRAF-mutated radioactive iodine refractory papillary thyroid cancer cellsInternational Journal of Biological SciencesJanuary 15, 2026Mickaëlle Radom, Camille Buffet, Juliana Cazarin, Marylin Harinquet, Caroline Coelho de Faria, Floriane Brayé, Catline Nobre, Marine Aglave, Yasmina Mesloub, Thibault Dayris, et al.#4354-MC-050, 1:50 diluted in 2.5% BSA/PBS) or with mouse IgG2B isotype control (Biotechne/R&D systems #MAB004) for 1 h at 37 °C. The cells were then washed once with 0.2% BSA/PBS and incubated with the secondary

(4) Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down SyndromeImmunologyNovember 27, 2025Koki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki TakataR&D Systems, AF644), anti‐VEGFR3 (1:80, R&D Systems, AF743), Mouse IgG2B Isotype Control (1:200, R&D Systems, MAB004) and Normal Goat IgG Control (1:40, R&D Systems, AB‐108‐C) in blocking buffer for 20 min at 4°C. The

(5) Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapyCell reports. MedicineSeptember 16, 2025Hirade K, Tanaka N, Kajino T, Adachi Y, Kimura R, Kasuya H, Kisoda S, Tan TK, Hayakawa S, Sato T, et al.RRID:AB_2894817 Atezolizumab,Chugai Pharmaceutical,N/A Mouse IgG2B Isotype Control,R & D Systems,Cat: MAB004;RRID:AB_357346 Rabbit (DA1E) mAb IgG Isotype Control,CST,Cat: 3900;RRID:AB_1550038 CD3ε (mouse),Biolegend,Cat.

(6) The lncRNA EPIC1 suppresses dsRNA-induced type I IFN signaling and is a therapeutic target to enhance TNBC response to PD-1 inhibitionScience SignalingAugust 12, 2025Dhamotharan Pattarayan, Yue Wang, Zehua Wang, Sihan Li, Xiaofei Wang, Yuang Chen, Yifei Wang, Chien-Yu Chen, Avishek Bhuniya, Ghanshyam Singh Yadav, et al.used at a concentration of 50 to 100 pg/mL. Human IFNa/bR2 (#MAB4015) and isotype control antibodies (#MAB004) were purchased from R&D Systems and were used at a concentration of 10 μg/mL for naturalization. RNA-seq

(7) Validation of a potency assay for CD34 + cell based therapySci RepAugust 11, 2025Christine Vignon, Arthur Cormier, Aurélien Goubaud, Hélène Schaffhauser, Sara Bennaoum, Eva Grotzinger, Jean-Olivier Hirsch, Philippe Hénon, Matthieu de Kalbermatten, Ibon Garitaonandiaµg/mL anti-VEGF neutralizing antibody (MAB293-SP, Bio-Techne), 10 µg/mL isotype control IgG antibody (MAB004, Bio-Techne), or increasing concentrations of VEGF (0, 0.025, 0.05, 0.1, 0.25, 0.5, 1, and 2 ng/mL)

(8) A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contractionImmunityJune 10, 2025Jubayer Rahman, Jack A. Bibby, Parul Singh, Nicolas S. Merle, Erin E. West, Andrea Bohrer, Katrin Mayer-Barber, Chengyu Liu, Lauren R. Brinster, Behdad Afzali, et al.AB_399879 APC-anti-goat IgG,R & D Systems,Cat# F0108; RRID: AB_573124 Mouse monoclonal IgG (20116),R & D Systems,Cat# MAB004; RRID: AB_357346 APC-anti-human IL-10,Biolegend,Cat# 506807; RRID: AB_315457 PE-Violet 770-anti-human

(9) Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHTAngiogenesisMarch 1, 2025Antonio Queiro-Palou, Yi Jin, Lars Jakobsson15 mg/kg, IgG2a, MAB2926; R&D Systems, respectively) or isotype control antibodies (15 mg/kg, IgG2b, MAB004; 15 mg/kg, IgG2a, MAB003; R&D Systems, respectively) at P3, P4 and P5 and tissues were harvested at

(10) Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokinesNature communicationsFebruary 26, 2025Parween F, Singh SP, Kathuria N, Zhang HH, Ashida S, Otaizo-Carrasquero FA, Shamsaddini A, Gardina PJ, Ganesan S, Kabat J, et al.R&D Systems or with mouse IgG1 isotype control (5 μg, Cat# MAB002) or mouse IgG2B isotype control (Cat# MAB004) from R&D Systems, or with anti-human GOLPH2 (2 μg, Cat# PA5-30622) or rabbit IgG isotype control from

(11) Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signalingFront ImmunolFebruary 3, 2025Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie PanClone 191004, MAB1547, Novus Biologicals), or IgG isotype control (dose: 300 μg per mouse, Clone 20116, MAB004, Novus Biologicals). Twenty-four hours later, the pretreated MDA-MB-231 cells were labeled with CFSE

(12) Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer's diseaseNature communicationsJanuary 2, 2025Wu W, Zhao Y, Cheng X, Xie X, Zeng Y, Tao Q, Yang Y, Xiao C, Zhang Z, Pang J, et al.μL of mouse mAb158 (Absolute Antibody, Wilton Center; 1 μg/μL in PBS) or the control mouse mIgG2B (MAB004, R&D System, USA) was injected86. The mice were allowed to recover on a heating pad until fully awake. Lymphatic

(13) BMP-9 mediates fibroproliferation in fibrodysplasia ossificans progressiva through TGF-β signalingEMBO molecular medicineJanuary 1, 2025Zhao C, Inada Y, Motoike S, Kamiya D, Hino K, Ikeya M.Human/Mouse/Primate BMP-9 monoclonal antibody (MAB3209; R&D Systems) or mouse IgG2B isotype control antibody (MAB004; R&D Systems) at 10 mg/kg body weight, twice a week from the day of CTX injection for 1 week (0–1 W),

(14) ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet functionEuropean Journal of Clinical InvestigationJanuary 1, 2025Valerie Dicenta‐Baunach, Zoi Laspa, David Schaale, Manuel Sigle, Alp Bayrak, Tatsiana Castor, Thanigaimalai Pillaiyar, Stefan Laufer, Meinrad Paul Gawaz, Anne‐Katrin Rohlfing(ab72100, abcam, Cambridge, United Kingdom) or corresponding IgG controls (Mouse IgG2B Isotype Control MAB004 R&D Systems, Minneapolis, Minnesota, USA and rabbit IgG Isotype Control 3900S Cell Signaling Technology,

(15) Chemokine receptor hetero-oligomers regulate monocyte chemotaxisLife science allianceAugust 1, 2024Enten GA, Gao X, McGee MY, Weche M, Majetschak M.IgG isotype control (host: rabbit, catalog#: MAB1050), IgG isotype control (host: mouse, catalog#: MAB004), and IgG isotype control (host: goat, catalog#: AB-108-C) were from R&D Systems. CCL2, CCL2325-99,

(16) A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodelingNature Cardiovascular ResearchJuly 8, 2024Hanqiang Deng, Jiasheng Zhang, Yewei Wang, Divyesh Joshi, Xinchun Pi, Sarah De Val, Martin A. SchwartzBMP10 (MAB2926, clone #462732), IgG2A isotype control (MAB003, clone #20102) and IgG2B isotype control (MAB004, clone #20116) were purchased from R&D Systems. Secondary antibodies were listed in Supplementary Table

(17) Leishmania braziliensis enhances monocyte responses to promote anti-tumor activityCell reportsMarch 26, 2024Dos Santos JC, Moreno M, Teufel LU, Chilibroste S, Keating ST, Groh L, Domínguez-Andrés J, Williams DL, Ma Z, Lowman DW, et al.

(18) Effect of Flavonoids on MCP-1 Expression in Human Coronary Artery Endothelial Cells and Impact on MCP-1-Dependent Migration of Human MonocytesInternational journal of molecular sciencesNovember 7, 2023Brüser L, Teichmann E, Hinz B.Recombinant Human MCP-1 (#554620) was purchased from BD Biosciences (Franklin Lakes, NJ, USA). IgG2B Isotype Control (#MAB004; RRID:AB_357346) and CCL2/JE/MCP-1 Antibody (#MAB679; RRID:AB_2071559) were obtained from R&D Systems

(19) A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor developmentNature communicationsOctober 28, 2023O'Keefe RN, Carli ALE, Baloyan D, Chisanga D, Shi W, Afshar-Sterle S, Eissmann MF, Poh AR, Pal B, Seillet C, et al.α-IL25 (R&D Systems, MAB13992), α-IL13 (R&D Systems, MAB413) or IgG control (R&D Systems, MAB006 and MAB004) (at 300 μg/mouse). 1 week after the last injection, mice were euthanized via CO2 asphyxiation. Stomachs

(20) Dectin-1-Independent Macrophage Phagocytosis of Mycobacterium abscessusInternational journal of molecular sciencesJuly 4, 2023Ochoa AE, Congel JH, Corley JM, Janssen WJ, Nick JA, Malcolm KC, Hisert KB.number: MAB1859, antibody clone #259931) or the Mouse IgG2B Isotype Control (R&D Systems catalog number: MAB004). Alternately, cells were incubated in laminarin 0.5–2 mg/mL (Thermo Fisher catalog number: J66193.MD)

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Mouse IgG2B Isotype Control

Mouse IgG2B Isotype Control

Mouse IgG2B Isotype Control

Mouse IgG2B Isotype Control from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Mouse IgG2B Isotype Control from R&D Systems, a Bio-Techne Brand

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