Fig 1: Cur combined with GB regulates the ASK1/JNK signaling pathway in Pkd1Flox/-; Ksp-Cre mice. (A) Representative western blotting of ASK1/JNK signaling proteins in Pkd1Flox/-;Ksp-Cre mice treated with 160 mg/kg Cur, 80 mg/kg GB and 160 mg/kg Cur combined with 80 mg/kg GB. (B) Semi-quantitative analysis of ASK1/JNK signaling protein expression in Pkd1Flox/-; Ksp-Cre mice. Relative level refers to the ratio of western blotting band density in different treatment groups compared with that in WT group. Data are presented as the mean ± SEM, n=6. ***P<0.001 vs. WT mice; ###P<0.001 vs. PKD mice. WT, wild-type; PKD, polycystic kidney disease; Cur, curcumin; GB, ginkgolide B; p-, phosphorylated; ASK1, activator of S phase kinase; MKK, mitogen-activated protein kinase kinase.