THP (B-2) Antibody sc-271022 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemTHP (B-2) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-271022
NCBI Gene AliasesHNFJ, ADTKD1, MCKD2, THGP, HNFJ1, FJHN, THP, urehr4, ADMCKD2, Urehd1
ApplicationsWB, IP, IF, IHC(P), ELISA
Hostmouse
CloneB-2
Quantity200 µg/ml
Conjugate/TagUnconjugated
ClonalityMonoclonal
FormatPurified
Antibody TypePrimary Antibodies
Reactivitymouse, rat, human
NCBI Full Gene Nameuromodulin
TargetTHP
IsotypeIgG1

Questions and Answers

What applications has the THP (B-2) antibody been used for in scientific research?

The THP (B-2) antibody has been shown to work in various applications including Western blotting, ELISA, immunofluorescence, immunohistochemistry, and immunoprecipitation, as evidenced by its use in multiple studies such as those by De Abreu et al. (2021) and Dong et al. (2021).

Is the THP (B-2) antibody effective for detecting uromodulin in different species?

Yes, the THP (B-2) antibody is reactive with uromodulin from multiple species, including humans, mice, and rats, making it suitable for comparative studies across these organisms.

How has the THP (B-2) antibody been utilized in the context of extracellular vesicle research?

The THP (B-2) antibody has been employed in studies focusing on small extracellular vesicles, particularly in Western blot analyses to characterize these vesicles and their protein content, as demonstrated in research by Kumar et al. (2021) and Teixeira-Marques et al. (2024).

Are there any specific findings related to the use of the THP (B-2) antibody in kidney-related studies?

Yes, the THP (B-2) antibody has been used to identify uromodulin in kidney tissues, contributing to research on kidney diseases and the role of uromodulin in renal function, as highlighted in studies such as those by Sinha et al. (2023) and Takizawa et al. (2022).

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) Generation of Mice Harboring Bicc1 Conditional Null AllelesgenesisFebruary 1, 2026Chia‐Feng Liu, Steven Leon, Isabella Herrig, Oliver Wessely, W. H. Wilson TangPrimary antibodies were used at the following dilutions: NCC (ab3553, MilliporeSigma), 1:300; THP (sc‐271022, Santa Cruz Biotechnology), 1:150; AQP2 (sc‐515770, Santa Cruz Biotechnology), 1:150; Ki‐67 (550609,

(2) Light Chain Cast Nephropathy: The Relationship between Tamm-Horsfall Protein Immunoreactivity and Clinical Pathological Features and PrognosisKidney Dis (Basel)January 22, 2026Ming-Yue Wang, Zi-Hao Yong, Shuang Wang, Su-Xia Wang, Xu-Jie Zhou, Yu-Jun Dong, Ming-Hui Zhao, Xiao-Juan Yu, Fu-De Zhouhydrogen peroxide, the sections were incubated overnight at 4°C with the anti-human THP antibody (1:200, sc-271022, Santa Cruz Biotechnology, USA). The primary antibody was detected by incubation with a secondary antibody

(3) Proteomic analysis of altered urinary extracellular vesicle levels in breast cancer patients pre- and post-surgeryTranslational Cancer ResearchDecember 31, 2025Nilobon Jeanmard, Rassanee Bissanum, Sawanya Charoenlappanit, Sittiruk Roytrakul, Raphatphorn NavakanitworakulDanvers, MA, USA), TSG101 (cat#72312; Cell Signaling Technology, Inc., Danvers, MA, USA), THP (cat#sc-271022; Santa Cruz Biotechnology, Dallas, TX, USA), and cytochrome C (cat#4272T; Cell Signaling Technology,

(4) Uromodulin alleviates fibrosis in acute kidney injury to chronic kidney disease transition by reducing EGFRCell Commun SignalDecember 29, 2025Zheyu Xing, Kunjing Gong, Na Wang, Lufeng Bai, Nan Hu, Di Song, Yuqing Chenanti-uromodulin antibody (ab207170, Abcam, UK, RRID: AB_2889163), mouse monoclonal anti-uromodulin antibody (sc-271022, Santa Cruz, USA, RRID: AB_10610634), rabbit monoclonal anti-EGFR(p1068) antibody (ab40815, Abcam, UK,

(5) Differentiation of high risk prostate cancer with a facile urinary exosome detection workflowiScienceFebruary 21, 2025Shuai Qiu, Yue Li, Zheng Zhang, Chunchang Li, Haoyu Wang, Ao Chen, Zhi Yan, Yang Liu, Zifei Li, Hua Huang, et al.,Santa Cruz,Cat#sc-13118; RRID: AB_627213 Anti-Alix,Santa Cruz,Cat#sc-53540; RRID: AB_673819 Anti-THP,Santa Cruz,Cat#sc-271022; RRID: AB_10610634 Anti-mouse IgG HRP-linked,Cell Signaling Technology,Cat#7076; RRID: AB_330924 ,, Biological

(6) Improved recovery of urinary small extracellular vesicles by differential ultracentrifugationScientific ReportsMay 28, 2024Ana Teixeira-Marques, Sara Monteiro-Reis, Diana Montezuma, Catarina Lourenço, Miguel Carlos Oliveira, Vera Constâncio, José Pedro Sequeira, Carina Carvalho-Maia, Rui Freitas, Elena S. Martens-Uzunova, et al.Santa Cruz Biotechnology, Texas, USA), Alix (1:300; sc-53540, Santa Cruz Biotechnology, Texas, USA), THP (1:500; sc-271022, Santa Cruz Biotechnology, Texas, USA), Cytochrome C (1:500, sc-13560, Santa Cruz Biotechnology, Texas,

(7) Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney developmentFrontiers in Cell and Developmental BiologySeptember 4, 2023Jinshu Xu, Xianxiao Zhou, Ting Zhang, Bin Zhang, Pin-Xian Xuantibodies: anti-Smarca4/Brg1 (ab110641, Abcam), -Wt1 (sc192, Santa Cruz Biotechnology); -THP (Santa Cruz, sc-271022), -NCC (EMD Millipore, AB3553), –phosphohistone-H3 (EMD Millipore, 06-570), -Tnnt2 (ab209813, Abcam),

(8) Ciliary ARL13B inhibits developmental kidney cystogenesis in mouseDevelopmental biologyAugust 1, 2023Van Sciver RE, Long AB, Katz HG, Gigante ED, Caspary T.11343-1-AP); rabbit anti-NCC (1:500, StressMarq Biosciences, SPC-402D); mouse anti-THP (1:250, Santa Cruz, sc-271022). Lectins used were fluorescein conjugated Lotus tetragonolobus lectin (1:300, LTL, Vector Laboratories,

(9) Ciliary ARL13B inhibits developmental kidney cystogenesis in mousebioRxiv : the preprint server for biologyMay 15, 2023Van Sciver RE, Long AB, Katz HG, Gigante ED, Caspary T.11343–1-AP); rabbit anti-NCC (1:500, StressMarq Biosciences, SPC-402D); mouse anti-THP (1:250, Santa Cruz, sc-271022). Lectins used were fluorescein conjugated Lotus tetragonolobus lectin (1:300, LTL, Vector Laboratories,

(10) The Reduction of Uromodulin, Complement Factor H, and Their Interaction Is Associated with Acute Kidney Injury to Chronic Kidney Disease Transition in a Four-Time Cisplatin-Injected Rat ModelInternational journal of molecular sciencesApril 2, 2023Xing Z, Gong K, Hu N, Chen Y.monoclonal anti-alpha-smooth muscle actin (α-SMA) (ab7817, Abcam, UK), mouse anti-uromodulin antibody (sc-271022, Santa Cruz Bio., Dallas, TX, USA), mouse monoclonal anti-GAPDH antibody (ab8245, Abcam, UK), and rabbit

(11) Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosiseLifeFebruary 1, 2023Du C, Xu H, Cao C, Cao J, Zhang Y, Zhang C, Qiao R, Ming W, Li Y, Ren H, et al.from R&D Systems (Minneapolis, MN, USA). Primary antibodies against AQP1 (Cat#sc25287) and THP (Cat#sc271022) were purchased from Santa Cruz Biotechnology, and antibodies against NCC (Cat#ab95302) and AQP2 (Cat#ab199975)

(12) Empagliflozin increases kidney weight due to increased cell size in the proximal tubule S3 segment and the collecting ductFrontiers in pharmacologyJanuary 1, 2023Sinha F, Federlein A, Biesold A, Schwarzfischer M, Krieger K, Schweda F, Tauber P.abcam, Cambridge, United Kingdom) for the proximal tubule S1/S2 segment, Tamm-Horsfall-protein (THP; sc-271022, Santa Cruz Biotechnology, Dallas, TX, United States) for the loop of Henle, calbindin (Calbindin D-28k;

(13) Urinary extracellular vesicles signature for diagnosis of kidney diseaseiScienceNovember 18, 2022Takizawa K, Ueda K, Sekiguchi M, Nakano E, Nishimura T, Kajiho Y, Kanda S, Miura K, Hattori M, Hashimoto J, et al.monoclonal anti-GGT1 antibody (Cat# sc-166908, Santa Cruz), mouse monoclonal anti-THP (UMOD) antibody (Cat# sc-271022, Santa Cruz), rabbit polyclonal anti-PGK1 antibody (Cat# 17811-1-AP, Proteintech), rabbit polyclonal

(14) Metabolite profiling of CKD progression in the chronic renal insufficiency cohort studyJCI insightOctober 24, 2022Wen D, Zheng Z, Surapaneni A, Yu B, Zhou L, Zhou W, Xie D, Shou H, Avila-Pacheco J, Kalim S, et al.Santa Cruz Biotechnology Inc.); mouse anti-AQP2 (sc515770, lot no. I0519, Santa Cruz Biotechnology Inc.); and mouse anti-THP (sc271022, lot no. B1219, Santa Cruz Biotechnology Inc.) (all diluted 1:500, incubated overnight). After washing

(15) Rapid Isolation of Extracellular Vesicles Using a Hydrophilic Porous Silica Gel-Based Size-Exclusion Chromatography ColumnAnalytical chemistryOctober 11, 2022Yoshitake J, Azami M, Sei H, Onoshima D, Takahashi K, Hirayama A, Uchida K, Baba Y, Shibata T.Mouse anti-Alix (1A12) monoclonal antibody (sc-53540) and mouse anti-THP (B-2) monoclonal antibody (sc-271022) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). Statistical Analysis All quantification

(16) Telomerase is required for glomerular renewal in kidneys of adult miceNPJ Regenerative medicineFebruary 11, 2022Montandon M, Hamidouche T, Yart L, Duret LC, Pons C, Soubeiran N, Pousse M, Cervera L, Vial V, Fassy J, et al.Santa Cruz Biotechnology, Ref# sc-25287), Mouse Monoclonal THP-specific (1:200, Santa Cruz Biotechnology, Ref# sc-271022), Rabbit polyclonal NCC-specific (1:100, Sigma, Ref# AB3553), biotinylated-LTL (1:200, Vector Laboratories,

(17) Reduced expression of TAZ inhibits primary cilium formation in renal glomeruliExperimental & molecular medicineFebruary 1, 2022Jun JH, Lee EJ, Park M, Ko JY, Park JH.

(18) Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysisJournal of extracellular vesiclesFebruary 1, 2022Correll VL, Otto JJ, Risi CM, Main BP, Boutros PC, Kislinger T, Galkin VE, Nyalwidhe JO, Semmes OJ, Yang L.1:1000), mouse anti‐TSG101 (BD Biosciences 612696, 1:500), and mouse anti‐THP (Santa Cruz Biotechnology sc‐271022, 1:1000), rabbit anti‐beta‐actin (Invitrogen, PA1‐16889, 1:5000), donkey anti‐mouse IgG IRDye 800CW

(19) Two-Step Competitive Hybridization Assay: A Method for Analyzing Cancer-Related microRNA Embedded in Extracellular VesiclesAnalytical chemistryDecember 7, 2021Saha S, Allelein S, Pandey R, Medina-Perez P, Osman E, Kuhlmeier D, Soleymani L.

(20) The polysaccharide chitosan facilitates the isolation of small extracellular vesicles from multiple biofluidsJournal of extracellular vesiclesSeptember 1, 2021Kumar A, Dhadi SR, Mai NN, Taylor C, Roy JW, Barnett DA, Lewis SM, Ghosh A, Ouellette RJ.sc‐13538), tetranectin (TETN, sc‐376940), serum amyloid A (SAA, sc‐59679), and Tamm‐Horsfall protein (THP, sc‐271022), were purchased from Santa Cruz Biotechnology. Flotillin‐1 (FLOT1, #186345) antibody was purchased

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THP (B-2) Antibody

THP (B-2) Antibody from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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THP (B-2) Antibody from Santa Cruz Biotechnology, Inc.

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