Integrin beta 6 Antibody AF2389 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIntegrin beta 6 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF2389
NCBI Gene Aliases2210409C20Rik, AI1H, 4831415H04Rik
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry
TargetIntegrin beta 6
IsotypeIgG
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Conjugate/TagUnconjugated
ReactivityHuman,Mouse
HostGoat
Quantity100 ug (also 25 ug)
NCBI Full Gene Nameintegrin subunit beta 6, integrin beta 6
ClonalityPolyclonal
ImmunogenChinese hamster ovary cell line CHO-derived recombinant mouse Integrin ß6, Gly22-Asn706, Accession # Q9Z0T9
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse Integrin ß6 in direct ELISAs and Western blots.

Sizes Available: 100 ug (also 25 ug)

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Questions and Answers

Can this antibody be used to study integrin beta 6 in muscle tissue?

Yes, the Integrin beta 6 Antibody has been shown to work in immunohistochemistry applications to detect ITGB6 protein levels in skeletal muscle. A study demonstrated that ITGB6 protein accumulates in myofibers adjacent to muscle injury sites, indicating its relevance in muscle regeneration processes ().

Is the Integrin beta 6 Antibody effective for use in dental research?

The antibody has been utilized in research related to enamel biomineralization, where it was found that αvβ6 integrin, which includes the beta 6 subunit, plays a critical role in ameloblast adhesion and matrix production during enamel formation ().

How does this antibody perform in kidney studies?

The Integrin beta 6 Antibody has been employed in immunofluorescence and immunohistochemistry to investigate podocyte-PEC interactions in kidney pathology. It has been implicated in signaling pathways that are crucial for maintaining podocyte homeostasis and preventing aberrant activation of parietal epithelial cells in glomerulopathies ().

Are there any known applications of this antibody in liver research?

Yes, the Integrin beta 6 Antibody has been used to explore the role of myofibroblasts in liver fibrosis, specifically in studies showing that laminin-αvβ6 integrin interactions induce hepatocyte-to-ductal metaplasia, highlighting its importance in liver regeneration mechanisms ().

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Multimodal Imaging Demonstrates Antifibrotic Effects of Targeting α v β 6 /α v β 1 Integrins in Biliary FibrosisInvestigative RadiologyJanuary 1, 2026Yingying Ning, Iris Y. Zhou, Johanna R. Schaub, Nicholas J. Rotile, Avery Boice, Ilknur Ay, Scott Turner, Peter Caravansections at Premier Laboratory (Colorado, USA) using an anti-integrin beta 6 antibody (R&D Systems, AF2389). In the pilot study (Figure 2), immunohistochemistry for integrin β6 was performed on 5 μm FFPE sections

(2) Small extracellular vesicle-mediated ITGB6 siRNA delivery downregulates the αVβ6 integrin and inhibits adhesion and migration of recipient prostate cancer cellsCancer biology & therapyDecember 31, 2022Krishn SR, Garcia V, Naranjo NM, Quaglia F, Shields CD, Harris MA, Kossenkov AV, Liu Q, Corey E, Altieri DC, et al.antibodies (Abs) were used for IB analyses: goat polyclonal Ab against the αVβ6 integrin (R&D Systems, AF2389); mouse monoclonal Abs against: αVβ6 integrin (Biogen, 6.2A1), ALIX (Abcam, ab117600), AR (Santa Cruz,

(3) IFIT3 (interferon induced protein with tetratricopeptide repeats 3) modulates STAT1 expression in small extracellular vesiclesThe Biochemical journalNovember 12, 2021Naranjo NM, Salem I, Harris MA, Languino LR.ab125011); and goat-affinity purified polyclonal Abs against the β6 integrin subunit (R&D Systems, AF2389). The following secondary Abs were used for IB analyses: HRP-linked anti-mouse IgG (Cell Signaling,

(4) Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidneyScience advancesSeptember 3, 2021Pace JA, Bronstein R, Guo Y, Yang Y, Estrada CC, Gujarati N, Salant DJ, Haley J, Bialkowska AB, Yang VW, et al.anti-WT1 (sc-7385, Santa Cruz Biotechnology Inc.), rat anti-CD44 (103001, BioLegend), mouse anti-ITGB6 (AF2389, R&D Systems), and rabbit anti-FN (AB2033, Millipore) was performed as recently reported (13, 59, 60).

(5) Myofibroblast induces hepatocyte-to-ductal metaplasia via laminin-ɑvβ6 integrin in liver fibrosisCell death & diseaseMarch 23, 2020Xu T, Lu Z, Xiao Z, Liu F, Chen Y, Wang Z, Zhu S, Song Y.anti-CD31,Abcam,IHC,ab28364 Goat anti-GFP,Abcam,IF,ab6673 Rat anti-F4/80,Abcam,IHC,ab6640 Goat anti-ITGB6,R&D systems,"IHC, IF",AF2389 Rabbit anti-ITGB6,ABclonal technology,WB,A16904 Rabbit anti-Alb,Proteintech,IF,16475-1-AP Rabbit

(6) Suppression of αvβ6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial CellsScientific reportsJune 30, 2017Bi J, Koivisto L, Pang A, Li M, Jiang G, Aurora S, Wang Z, Owen GR, Dai J, Shen Y, et al.USA) and TLR6 (PAb hTLR6; InvivoGen). Primary antibodies used for Western blotting were: β6 integrin (AF2389; R&D Systems, Inc., Minneapolis, MN, USA), β-actin (Ab8227; Abcam), β-tubulin (MAB3408; EMD Millipore),

(7) Post-transcriptional regulation of ITGB6 protein levels in damaged skeletal muscleJournal of molecular histologyJune 1, 2014Ducceschi M, Clifton LG, Stimpson SA, Billin AN.followed by incubation with a goat anti-mouse integrin beta 6 polyclonal antibody (R&D Systems, catalog # AF2389) at 5ug/ml for 45 min at room temperature. Control non-immune goat IgG was used as a negative control

(8) Critical role for αvβ6 integrin in enamel biomineralizationJournal of cell scienceFebruary 1, 2013Mohazab L, Koivisto L, Jiang G, Kytömäki L, Haapasalo M, Owen GR, Wiebe C, Xie Y, Heikinheimo K, Yoshida T, et al.(#3103; Cell Signaling Technology, Danvers, MA, USA), pSmad2 (#3101; Cell Signaling), b6 integrin (AF2389; R&D Systems, Inc., Minneapolis, MN, USA), av integrin (sc-6618, Santa Cruz Biotechnology, Santa Cruz,

(9) Lunatic Fringe-mediated Notch signaling is required for lung alveogenesisAmerican journal of physiology. Lung cellular and molecular physiologyJanuary 1, 2010Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, et al.BT-562; Biomedical Technologies); CD31 (1:50; cat. no. ab28364; Abcam); ␤6-integrin (1:20; cat. no. AF2389; R&D Systems); PDGF receptor-␣ (PDGFR␣; 1:200; cat. no. sc-338; Santa Cruz Biotechnology); surfactant

(10) Phenotypic and genetic characterization of a novel phenotype in pigs characterized by juvenile hairlessness and age dependent emphysemaBMC GenomicsDecember 1, 2008Camilla S Bruun, Claus B Jørgensen, Lene Bay, Susanna Cirera, Henrik E Jensen, Páll S Leifsson, Jens Nielsen, Knud Christensen, Merete Fredholmmin. to reduce non-specific positive reaction. The sections were incubated with the primary antibody (#AF2389, R&D Systems Minneapolis, MN, USA) in 5% normal porcine serum in TBS, pH 7.6. for 18 h at 4°C, followed

(11) The NOGO receptor NgR2, a novel αVβ3 integrin effector, induces neuroendocrine differentiation in prostate cancerScientific reportsJanuary 1, 0001Quaglia F, Krishn SR, Sossey-Alaoui K, Rana PS, Pluskota E, Park PH, Shields CD, Lin S, McCue P, Kossenkov AV, et al.Cell Signaling) and Aurora Kinase A (14475S, Cell Signaling), polyclonal goat Abs against the αVβ6 integrin (AF2389, R&D system) and NgR2 (AF2776, R&D system), rabbit polyclonal Abs against calnexin (CANX, sc11397, Santa Cruz

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Mouse Integrin beta 6 Antibody

Integrin beta 6 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

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Integrin beta 6 Antibody from R&D Systems, a Bio-Techne Brand

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