Mouse LDLR Antibody AF2255 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse LDLR Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF2255
ApplicationsBlocking,ELISA Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Blockade of Receptor-ligand Interaction,Neutralization,Immunocytochemistry,CyTOF-ready
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
HostGoat
TargetLDLR
Conjugate/TagUnconjugated
IsotypeIgG
Quantity100 ug (also 25 ug)
ReactivityHuman,Mouse,Rat,Transgenic Mouse
ClonalityPolyclonal
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Namelow density lipoprotein receptor
NCBI Gene AliasesHlb301
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse LDL R, Ala22-Arg790 (Ala23Val, Cys27Gly), Accession # Q6GTJ9

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Absence of the intracellular lipolytic inhibitor G0S2 enhances intravascular triglyceride clearance and abolishes diet-induced hypertriglyceridemiaJournal of Clinical InvestigationMay 15, 2025Yongbin Chen, Scott M. Johnson, Stephanie D. Burr, Davide Povero, Aaron M. Anderson, Cailin E. McMahon, Jun Liufollowing rabbit polyclonal or mouse monoclonal primary antibodies were used: anti–mouse LDLR (R&D Systems, AF2255), anti–mouse G0S2 (affinity-purified rabbit polyclonal custom generated by Proteintech Group Inc.) (26),

(2) VSV(∆M51) drives CD8(+) T cell-mediated tumour regression through infection of both cancer and non-cancer cellsNature communicationsNovember 15, 2024Rajwani J, Vishnevskiy D, Turk M, Naumenko V, Gafuik C, Kim DS, Mah LK, Snelling S, Gonzales GA, Xue J, et al.

(3) Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolismNeuronSeptember 4, 2024Caterina P. Profaci, Sean S. Harvey, Kaja Bajc, Tony Z. Zhang, Danielle A. Jeffrey, Alexander Z. Zhang, Kelsey M. Nemec, Hayk Davtyan, Carleigh A. O’Brien, Gabriel L. McKinsey, et al.Wako Pure Chemical Corporation,Cat. # 019-19741; RRID: AB_839504 goat anti-LDLR,R&D Systems,Cat. # AF2255; RRID: AB_355203 rabbit anti-CLDN5,Thermo Fisher Scientific,Cat. # 34-1600; RRID: AB_2533157 rabbit

(4) DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in miceiScienceJune 21, 2024Ge X, Slütter B, Lambooij JM, Zhou E, Ying Z, Agirman C, Heijink M, Rimbert A, Guigas B, Kuiper J, et al.MP-7444; RRID: AB_2336530 ICAM-1,Sino Biological,Cat# 50440-R020; RRID: AB_2860508 LDLR,R&D system,Cat# AF2255; RRID: AB_355203 Ly6C,Biolegend,Cat# 128033; RRID: AB_2562351 Ly6C,eBioscience,Cat# 17-59432-82 Ly6G,Biolegend,Cat#

(5) A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primatesNPJ vaccinesSeptember 28, 2023Fowler A, Van Rompay KKA, Sampson M, Leo J, Watanabe JK, Usachenko JL, Immareddy R, Lovato DM, Schiller JT, Remaley AT, et al.membranes (Bio-Rad). Membranes were probed using goat anti-mouse LDLR at a 1:500 dilution (catalogue number AF2255; R&D Systems) or goat anti-human LDLR at a 1:500 dilution (catalogue number AF2148; R&D Systems) followed

(6) Delivery of low-density lipoprotein from endocytic carriers to mitochondria supports steroidogenesisNature cell biologyJuly 1, 2023Zhou YX, Wei J, Deng G, Hu A, Sun PY, Zhao X, Song BL, Luo J.

(7) Proteolysis of the low‐density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteasesFEBS LettersJune 5, 2023Katherine A. B. Kellett, Kate Fisher, Harry Aldworth, Nigel M. Hooperin primary antibody diluted in 2% BSA in PBS‐T: goat anti‐human LDLR (AF2148), goat anti‐mouse LDLR (AF2255; R&D Systems, Minneapolis, MN, USA), chicken anti‐LDLR (Ab14056; Abcam, Cambridge, UK) at a dilution

(8) A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human PrimatesbioRxiv : the preprint server for biologyMay 15, 2023Fowler A, Van Rompay KKA, Sampson M, Leo J, Watanabe JK, Usachenko JL, Immareddy R, Lovato DM, Schiller JT, Remaley AT, et al.

(9) Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J miceEuropean journal of nutritionDecember 1, 2022Hjorth M, Doncheva A, Norheim F, Ulven SM, Holven KB, Sæther T, Dalen KT.appropriate HRP-conjugated secondary antibodies. Primary antibodies used were as follows: Goat anti-Ldlr (#AF2255, R&D Systems), goat anti-Pcsk9 (#AF3985, R&D Systems, Minneapolis, MN, US), rabbit anti-Hmgcr (#PA5-37,367,

(10) Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosisJournal of lipid researchMarch 1, 2022Gomes D, Wang S, Goodspeed L, Turk KE, Wietecha T, Liu Y, Bornfeldt KE, O'Brien KD, Chait A, den Hartigh LJ.Rockford, IL). Immunoblots were performed on equal amounts of protein and probed for the LDLR (catalog no.: AF2255; R&D Systems, goat polyclonal, Minneapolis, MN), ApoB100 and ApoB48 (catalog no.: ab20737; Abcam, rabbit

(11) Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected miceLipids in health and diseaseOctober 10, 2021Haberl EM, Pohl R, Rein-Fischboeck L, Höring M, Krautbauer S, Liebisch G, Buechler C.

(12) A host lipase prevents lipopolysaccharide-induced foam cell formationiScienceSeptember 24, 2021Feng J, Jiang W, Cheng X, Zou B, Varley AW, Liu T, Qian G, Zeng W, Tang J, Zhao Q, et al.RRID:AB_2832971 Anti-ABCA1 Antibody (clone AB.H10),Abcam,Cat# ab18180; RRID:AB_444302 Mouse LDLR Antibody,R&D systems,Cat# AF2255; RRID:AB_355203 HRP-Conjugated β Actin Monoclonal Antibody,Proteintech,Cat# HRP-66009; RRID:AB_2883836 ,, Bacterial

(13) Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanismsNeuronAugust 4, 2021Shi Y, Andhey PS, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Yamada K, Qin W, Manis M, et al.GFAP: Abcam, Cat# ab7260; ApoE: HJ6.3, in house; Iba1: Wako, Cat# 019-19741; LDLR: R&D Systems, Cat# AF2255; Vimentin: Santa Cruz, Ca# sc-373717, CSPG4: Sigma, Cat# AB5320; MBP: Abcam, Cat# ab40390) in stain

(14) Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1CancersJune 29, 2021Kabe Y, Koike I, Yamamoto T, Hirai M, Kanai A, Furuhata R, Tsugawa H, Harada E, Sugase K, Hanadate K, et al.EGFR (Cell Signaling Technology, Danvers, MA, USA: #2232S), LDLR (R&D Systems, Minneapolis, MN, USA: AF2255), phospho-Y1068 EGFR (Cell Signaling Technology: #2234S), AKT (Cell Signaling Technology: #9272S), phospho-S473AKT

(15) Characterization of PCSK9 in the Blood and Skin of PsoriasisThe Journal of investigative dermatologyFebruary 1, 2021Garshick MS, Baumer Y, Dey AK, Grattan R, Ng Q, Teague HL, Yu ZX, Chen MY, Tawil M, Barrett TJ, et al.with the according primary antibody over night at 4°C (PCSK: Novus Bio NBP2–31364 at 5μg/ml, LDLR: R&D AF2255 at 15μg/ml). The following day sections were washed using PBS 3 times and incubated with a biotinylated

(16) SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarityThe Journal of cell biologyJanuary 4, 2021Kunii M, Noguchi Y, Yoshimura SI, Kanda S, Iwano T, Avriyanti E, Atik N, Sato T, Sato K, Ogawa M, et al.(rat; Chemicon, MAB1997), anti–ephrin-B1 (goat; R&D Systems, AF473), anti-LDLR (goat; R&D Systems, AF2255), anti–Na+/K+-ATPase β subunit (rabbit antisera; a kind gift from Dr. Haruo Homareda, Kyorin University,

(17) Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative StateFrontiers in cardiovascular medicineJanuary 1, 2021Louloudis G, Ambrosini S, Paneni F, Camici GG, Benke D, Klohs J.1 h. They were probed overnight with a goat anti-mouse LDL receptor antibody (1:2,000, R&D Systems, AF2255) in TBST-Tween-20 (TBS-T, 0.05% Tween-20) solution containing 5% milk, at 4°C. Membranes were washed

(18) Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific MannerCellular and molecular gastroenterology and hepatologyJanuary 1, 2021Chella Krishnan K, Floyd RR, Sabir S, Jayasekera DW, Leon-Mimila PV, Jones AE, Cortez AA, Shravah V, Péterfy M, Stiles L, et al.MA), goat polyclonal PCSK9 (R&D Systems #AF3985; Minneapolis, MN), goat polyclonal LDLR (R&D Systems #AF2255), mouse polyclonal PNPLA3 (Abcam # ab69170; Cambridge, United Kingdom), and rabbit monoclonal GAPDH

(19) An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossingNature communicationsNovember 30, 2020Benmimoun B, Papastefanaki F, Périchon B, Segklia K, Roby N, Miriagou V, Schmitt C, Dramsi S, Matsas R, Spéder P.rabbit anti-CD31(1:50; Abcam, Cambridge, UK; ab28364), goat anti-LDLR (1:100, R&D Systems, MN, USA; AF2255), rabbit anti-GBS (1:300; homemade). Secondary antibodies (all from ThermoFisher Scientific) used for

(20) BLOS1 mediates kinesin switch during endosomal recycling of LDL receptoreLifeNovember 12, 2020Zhang C, Hao C, Shui G, Li W.antibodies were used (additional information was shown in Appendix 1): anti-mouse LDLR (R and D, Cat#AF2255, 1/100), anti-human LDLR (R and D, Cat#AF2148, 1/100), anti-TfR (1/200), anti-EEA1 (1/500), anti-Cytochrome

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Mouse LDLR Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Mouse LDLR Antibody from R&D Systems, a Bio-Techne Brand

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