GDF-15 Antibody AF957 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemGDF-15 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF957
ApplicationsELISA Development,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Simple Western,Neutralization,Immunocytochemistry
Conjugate/TagUnconjugated
HostGoat
TargetGDF-15
IsotypeIgG
ClonalityPolyclonal
ImmunogenChinese hamster ovary cell line CHO-derived recombinant human GDF-15, Ala197-Ile308, Accession # Q99988
ConcentrationLYOPH
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
PurityAntigen Affinity-purified
ReactivityHuman (Hu)
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Quantity100 ug (also 25 ug)
NCBI Gene AliasesGDF-15, NAG-1, MIC1, PTGFB, MIC-1, PDF, PLAB
NCBI Full Gene Namegrowth differentiation factor 15

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human GDF-15 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 65% cross-reactivity with recombinant mouse (rm) GDF-15 is observed, and less than 1% cross-reactivity with rmGDF-1, rmGDF-3, and rmGDF-11 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) GDF15 Reprograms the Microenvironment to Drive Liver Metastasis of Uveal MelanomaCancer ResMay 28, 2026Sathya Sriramareddy, Navya Siddarajappa, Jun Sung Park, Thanh Nguyen, Jeffim N. Kuznetsoff, Stefan Kurtenbach, James J. Dollar, David J. Adams, Jonathan D. Licht, Zelia M. Correa, et al.(Danvers, MA). BAP1 (#sc-28383, RRID: AB_626723, Santa Cruz Biotechnology, Dallas, TX, USA), GDF15 (# AF957, RRID: AB_2110860, R&D systems). PRAME (RRID: AB_3675562, Abcam, #ab219650), Anti-vinculin (V9131, RRID:

(2) GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastasesbioRxivJune 10, 2025Sathya Neelature Sriramareddy, Navya Siddarajappa, Jun Sung Park, Thanh Nguyen, Jeffim N. Kuznetsoff, Stefan Kurtenbach, James J. Dollar, David J. Adams, Jonathan D. Licht, Zelia M. Correa, et al.Cell Signaling Technologies (Danvers, MA). BAP1 (#sc-28383, Santa Cruz Biotechnology, Dallas, TX, USA), GDF15 (# AF957, R&D systems). Anti-vinculin (V9131), anti-GAPDH (G9545) antibodies were from Millipore Sigma. All primary

(3) GPX3 supports ovarian cancer tumor progression in vivo and promotes expression of GDF15bioRxiv : the preprint server for biologyJanuary 29, 2024Chang C, Cheng YY, Kamlapurkar S, White SR, Tang PW, Elhaw AT, Javed Z, Aird KM, Mythreye K, Phaëton R, et al.

(4) Identification of a novel ER-NFĸB-driven stem-like cell population associated with relapse of ER+ breast tumorsBreast cancer research : BCRDecember 8, 2022Semina SE, Alejo LH, Chopra S, Kansara NS, Kastrati I, Sartorius CA, Frasor J.methods Reagents 17β-estradiol (E2) was purchased from Sigma. TNFα (#210-TA) and GDF15 antibody (#AF957) were purchased from R&D Systems. ICI182,780 (ICI) (# I4409) and IKK7(#S2882) were purchased from Sigma

(5) Activity of Combined Androgen Receptor Antagonism and Cell Cycle Inhibition in Androgen Receptor Positive Triple Negative Breast CancerMolecular cancer therapeuticsJune 1, 2021Christenson JL, O'Neill KI, Williams MM, Spoelstra NS, Jones KL, Trahan GD, Reese J, Van Patten ET, Elias A, Eisner JR, et al.(#A0562, Agilent Technologies Inc., Santa Clara, CA), goat polyclonal antibody specific for GDF15 (#AF957, R&D Systems) and rabbit polyclonal antibody specific for CHI3L1 (#ab77528, Abcam). Tris-buffered saline

(6) Growth and differentiation factor 15 and NF-κB expression in benign prostatic biopsies and risk of subsequent prostate cancer detectionCancer medicineMay 1, 2021Rybicki BA, Sadasivan SM, Chen Y, Kravtsov O, Palangmonthip W, Arora K, Gupta NS, Williamson S, Bobbitt K, Chitale DA, et al.block (Background Punisher, Biocare). Antibodies used were goat polyclonal antibody to GDF‐15 (catalog AF957, R&D Systems, Minneapolis) and rabbit monoclonal antibody to NF‐κB p65 (clone D14E12, Cell Signaling

(7) An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cellsOncotargetApril 11, 2017Sasahara A, Tominaga K, Nishimura T, Yano M, Kiyokawa E, Noguchi M, Noguchi M, Kanauchi H, Ogawa T, Minato H, et al.was added 1 hour before treatment with GDF15. To neutralize GDF15, anti-GDF15 (R&D systems Inc., cat#AF957) was added 24 hours after treatment with GDF15, without changing the medium. Total RNA was prepared

(8) Panel of three novel serum markers predicts liver stiffness and fibrosis stages in patients with chronic liver diseasePloS oneJanuary 1, 2017Krawczyk M, Zimmermann S, Hess G, Holz R, Dauer M, Raedle J, Lammert F, Grünhage F.

(9) Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork CellsInvestigative ophthalmology & visual scienceDecember 1, 2016Muralidharan AR, Maddala R, Skiba NP, Rao PV.1:200 dilution of goat polyclonal primary antibody raised against recombinant (r) human GDF-15 (C.No. AF957, R&D Systems, Inc., Minneapolis, MN, USA). Slides then were washed and incubated with Alexa Fluor-488

(10) MAP3K11/GDF15 axis is a critical driver of cancer cachexiaJournal of cachexia, sarcopenia and muscleSeptember 1, 2016Lerner L, Tao J, Liu Q, Nicoletti R, Feng B, Krieger B, Mazsa E, Siddiquee Z, Wang R, Huang L, et al.murine GDF15 in vivo. All these antibodies were developed by AVEO Oncology Inc. (Cambridge, MA, USA). AF957 (R&D Systems, Minneapolis, MN, USA) is a goat anti‐human GDF15 polyclonal antibody that neutralizes

(11) Anti-tumoral effects of miR-3189-3p in glioblastomaThe Journal of biological chemistryMarch 27, 2015Jeansonne D, DeLuca M, Marrero L, Lassak A, Pacifici M, Wyczechowska D, Wilk A, Reiss K, Peruzzi F.

(12) Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostateThe ProstateFebruary 15, 2015Lambert JR, Whitson RJ, Iczkowski KA, La Rosa FG, Smith ML, Wilson RS, Smith EE, Torkko KC, Gari HH, Lucia MS.SC-18351; goat polyclonal), inos (Abcam; cat# Ab-15323; rabbit polyclonal) and GDF-15 (R&D Systems; cat# AF957; goat polyclonal; 1:100). The sections were rinsed thoroughly in TBST and endogenous peroxidases were

(13) Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytesEndocrinologyApril 1, 2009Ding Q, Mracek T, Gonzalez-Muniesa P, Kos K, Wilding J, Trayhurn P, Bing C.

(14) Prognostic value of growth-differentiation factor-15 in patients with non-ST-elevation acute coronary syndromeCirculationFebruary 27, 2007Wollert KC, Kempf T, Peter T, Olofsson S, James S, Johnston N, Lindahl B, Horn-Wichmann R, Brabant G, Simoons ML, et al.affinity chromatography-purified, goat anti-human GDF-15 IgG antibody from R&D Systems (Minneapolis, Minn) (AF957).15 In each experiment, a standard curve was generated with recombinant human GDF-15 from R&D Systems

(15) GDF-15 is abundantly expressed in plexiform lesions in patients with pulmonary arterial hypertension and affects proliferation and apoptosis of pulmonary endothelial cellsRespiratory researchJanuary 1, 0001"Nickel N, Jonigk D, Kempf T, Bockmeyer CL, Maegel L, Rische J, Laenger F, Lehmann U, Sauer C, Greer M, et al."(Additional file 2) was also performed using Goat anti-human GDF-15 IgG antibody (1:25, R&D Systems, cat. no. AF957). Microdissection of plexiform lesions Formalin-fixed, paraffin-embedded (FFPE) tissue sections 5

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GDF-15 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (15)

Reviews

GDF-15 Antibody from R&D Systems, a Bio-Techne Brand

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