IL-22 Antibody AF582 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-22 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF582
NCBI Gene AliasesIL-22a, zcyto18, IL-TIF, IL-22, IL-21, IL-D110, TIFa, ILTIF, Iltif, If2b1, TIFIL-23, ILTIFa
ApplicationsBioassay,ELISA Development,Flow Cytometry,Immunohistochemistry,Western Blot,Neutralization,ELISA Capture (Matched Antibody Pair)
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ReactivityMouse
HostGoat
IsotypeIgG
Quantity100 ug (also 25 ug)
Conjugate/TagUnconjugated
TargetIL-22
NCBI Full Gene Nameinterleukin 22
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant mouse IL-22, Leu34-Val179, Accession # Q9JJY9
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse IL-22 in ELISAs and Western blots. In sandwich immunoassays, approximately 75% cross-reactivity with recombinant rat IL-22 is observed and less than 25% cross-reactivity with recombinant human IL-22 is observed.

Sizes Available: 100 ug (also 25 ug)

Add to Compare List

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Administration of the NOD2 Agonist MDP Reduces Cryptosporidium parvum Infection in Neonatal Mice Through IL-22 InvolvementEuropean journal of immunologyOctober 1, 2025Fernandez M, Pezier T, Pichon J, Vern YL, Werts C, Lacroix-Lamandé S.

(2) mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapyCell reports. MedicineMarch 17, 2023Olivera I, Bolaños E, Gonzalez-Gomariz J, Hervas-Stubbs S, Mariño KV, Luri-Rey C, Etxeberria I, Cirella A, Egea J, Glez-Vaz J, et al.1B11; Cat# 121207; RRID:AB_493389 Anti-mouse affinity purified IL-22,R and D Systems,"Polyclonal; Cat# AF582, RRID:AB_355457" InVivoMAb anti-mouse E-selectin (CD62E),BioXCell,Clone 9A9; Cat#BE0294; RRID:AB_2687816 Rb

(3) Promoting Effect of L-Fucose on the Regeneration of Intestinal Stem Cells through AHR/IL-22 Pathway of Intestinal Lamina Propria MonocytesNutrientsNovember 12, 2022Tan C, Hong G, Wang Z, Duan C, Hou L, Wu J, Qian W, Han C, Hou X.experiment (Figure S1). L-fucose (5 mg/mL) and murine anti-IL-22 neutralizing antibody (0.1 μg/mL, AF582, R&D system, Minneapolis, MN, USA) were added independently or simultaneously to the culture medium

(4) TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailabilityMucosal immunologyApril 1, 2022Ninnemann J, Winsauer C, Bondareva M, Kühl AA, Lozza L, Durek P, Lissner D, Siegmund B, Kaufmann SHE, Mashreghi MF, et al.weight, they were treated with anti-human TNF antibody (Infliximab), anti-mouse IL-22 (R&D Systems; AF582) or human Fc-IgG1 isotype control (BioXCell; Cat # BE0096) in PBS. Anti-human TNF drugs were kindly

(5) Host immunology and rational immunotherapy for carbapenem-resistant Klebsiella pneumoniae infectionJCI insightApril 23, 2020Iwanaga N, Sandquist I, Wanek A, McCombs J, Song K, Kolls JK.

(6) A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver InjuryJournal of immunology (Baltimore, Md. : 1950)December 15, 2017Kleinschmidt D, Giannou AD, McGee HM, Kempski J, Steglich B, Huber FJ, Ernst TM, Shiri AM, Wegscheid C, Tasika E, et al.IL-22 (5 mg in 200 ml PBS; PeproTech, London, U.K.) 30 min before ischemia or an anti-mouse IL-22 (AF582; 50 mg in 200 ml PBS; R&D Systems, Minneapolis, MN) or an anti-mouse CXCL10 Ab 24 h before ischemia

(7) Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in MiceCell reportsOctober 31, 2017Nakamoto N, Amiya T, Aoki R, Taniki N, Koda Y, Miyamoto K, Teratani T, Suzuki T, Chiba S, Chu PS, et al.

(8) IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E₂ during Lung Fungal InfectionJournal of immunology (Baltimore, Md. : 1950)September 15, 2017Garth JM, Reeder KM, Godwin MS, Mackel JJ, Dunaway CW, Blackburn JP, Steele C.IgG isotype control antibody or polyclonal goat anti-mouse IL-17A (Cat. #AF-421-NA) or IL-22 (Cat. #AF582) or goat IgG isotype control antibody (Cat. #AB-108-C) (all antibodies from R&D Systems) intratracheally.

(9) Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia modelScientific reportsSeptember 8, 2017Broquet A, Jacqueline C, Davieau M, Besbes A, Roquilly A, Martin J, Caillon J, Dumoutier L, Renauld JC, Heslan M, et al.

(10) Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammationMucosal immunologySeptember 1, 2017Ji YW, Mittal SK, Hwang HS, Chang EJ, Lee JH, Seo Y, Yeo A, Noh H, Lee HS, Chauhan SK, et al.for immunohistochemistry and molecular studies. For in vivo IL-22 blockade experiments, 100 μg/mouse of αIL-22 (AF582, R&D Systems, Minneapolis, MN) or PBS were intravenously injected into WT mouse at 2-hour before placing

(11) Expression of IL-22 in the Skin Causes Th2-Biased Immunity, Epidermal Barrier Dysfunction, and Pruritus via Stimulating Epithelial Th2 Cytokines and the GRP PathwayJournal of immunology (Baltimore, Md. : 1950)April 1, 2017Lou H, Lu J, Choi EB, Oh MH, Jeong M, Barmettler S, Zhu Z, Zheng T.

(12) Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarizationScientific reportsNovember 3, 2016Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S.

(13) Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defenceNatureJuly 21, 2016Ibiza S, García-Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, Misic AM, Bartow-McKenney C, Larson DM, Pavan WJ, et al.

(14) Antibiotics in neonatal life increase murine susceptibility to experimental psoriasisNature communicationsSeptember 29, 2015Zanvit P, Konkel JE, Jiao X, Kasagi S, Zhang D, Wu R, Chia C, Ajami NJ, Smith DP, Petrosino JF, et al.450 48-5773-82, PE 12-5773-82, APC 17-5773-82, dilution 1:100). Neutralizing antibodies for IL-22 (AF582) were purchased from R&D Systems. Samples were analysed with a FACSCalibur and Cellquest software or

(15) IL-22 exacerbates the severity of CVB3-induced acute viral myocarditis in IL-17A-deficient miceMolecular medicine reportsApril 1, 2013Kong Q, Xue Y, Wu W, Yang F, Liu Y, Gao M, Lai W, Pan X.µg per mouse, n=8); in the anti-IL-22 Ab group, mice were administered with CVB3 and anti-IL-22 Ab (AF582; 50 µg per mouse; R&D Systems, Inc., Minneapolis, MN, USA; n=8); IgG control group, mice were injected

(16) Increased expressions of IL-22 and Th22 cells in the coxsackievirus B3-Induced mice acute viral myocarditisVirology journalOctober 11, 2012Kong Q, Wu W, Yang F, Liu Y, Xue Y, Gao M, Lai W, Pan X, Yan Y, Pang Y, et al.three groups: administered either Anti-IL-22 Ab (50 μg per mouse; R&D Systems, Inc. Minneapolis, MN.AF582; n=12,Anti-IL-22Ab group); an normal IgG control (50 μg per mouse; R&D Systems,Inc. Minneapolis,MN.AB-108-C; n=12,

(17) Interleukin-22: implications for liver ischemia-reperfusion injuryTransplantationMarch 15, 2012Chestovich PJ, Uchida Y, Chang W, Ajalat M, Lassman C, Sabat R, Busuttil RW, Kupiec-Weglinski JW.ischemia insult with rIL-22 (5 μg in 200 μl PBS; BioLegends, San Diego, CA) or goat anti-mouse IL-22 Ab (AF582; 50 μg in 200 μl PBS; R&D Systems, Minneapolis, MN). Controls received PBS (200 μl) or normal goat IgG (AB-1080C,

(18) Dectin-1-dependent interleukin-22 contributes to early innate lung defense against Aspergillus fumigatusInfection and immunityJanuary 1, 2012Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, Chan YR, Ouyang W, Brown GD, Weaver CT, et al.

(19) CCL20, γδ T cells, and IL-22 in corneal epithelial healingFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAugust 1, 2011Li Z, Burns AR, Miller SB, Smith CW.

(20) STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasisBloodJune 9, 2011Kaplan MH, Glosson NL, Stritesky GL, Yeh N, Kinzfogl J, Rohrabaugh SL, Goswami R, Pham D, Levy DE, Brutkiewicz RR, et al.

Be the First to Write a Review!

IL-22 Antibody

IL-22 Antibody

IL-22 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (25)

Reviews

IL-22 Antibody from R&D Systems, a Bio-Techne Brand

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map