TrkA Antibody AF175 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemTrkA Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF175
ApplicationsFlow Cytometry,Immunohistochemistry,Western Blot,Neutralization,Immunocytochemistry,CyTOF-ready,Functional Assay
Quantity100 ug (also 25 ug)
HostGoat
ReactivityHuman,Rabbit,Rat
TargetTrkA
IsotypeIgG
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant human TrkA, Ala33-Glu407, Accession # AAA36770
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameneurotrophic receptor tyrosine kinase 1
NCBI Gene AliasesMTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human TrkA in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant rat TrkA is observed and 10% cross-reactivity with recombinant human (rh) TrkB and rhTrKC is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Effect of Recombinant NGF Encapsulated in Chitosan on Rabbit Sperm Traits and Main Metabolic PathwaysBiology (Basel)August 1, 2025Luigia Bosa, Simona Mattioli, Anna Maria Stabile, Desirée Bartolini, Alessia Tognoloni, Alessandra Pistilli, Mariangela Ruggirello, Mario Rende, Silvia Gimeno-Martos, Daniela Jordán-Rodríguez, et al.Cells were then centrifuged and incubated for 1 h in PBS/BSA containing 2.5 μg/106 cells of anti-TrKA (AF175, R&D System, Minneapolis, MN, USA) and 2 μg/106 cells of anti-p75NTR (MA5–13314, Thermo Fisher Scientific,

(2) CRISPR-Edited DPSCs, Constitutively Expressing BDNF Enhance Dentin Regeneration in Injured TeethElifeJuly 9, 2025Ji Hyun Kim, Muhammad Irfan, Sreelekshmi Sreekumar, Atsawasuwan Phimon, Stephanie Kim, Seung ChungTechnology (Danvers, MA, USA). Various antibodies were procured: anti-TrkA (RRID:AB_354970, R&D Systems Cat# AF175), anti-phospho-TrkA (R&D Systems Cat# AF5479), anti-TrkB (RRID:AB_2686965, BioLegend Cat# 695102), anti-phospho-TrkB

(3) CRISPR-edited DPSCs constitutively expressing BDNF enhance dentin regeneration in injured teethElifeJuly 9, 2025Ji Hyun Kim, Muhammad Irfan, Sreelekshmi Sreekumar, Atsawasuwan Phimon, Stephanie Kim, Seung ChungTechnology (Danvers, MA, USA). Various antibodies were procured: anti-TrkA (RRID:AB_354970, R&D Systems Cat# AF175), anti-phospho-TrkA (R&D Systems Cat# AF5479), anti-TrkB (RRID:AB_2686965, BioLegend Cat# 695102), anti-phospho-TrkB

(4) Nerve growth factor receptor role on rabbit sperm storageTheriogenologySeptember 1, 2020Castellini C, Mattioli S, Bosco AD, Cotozzolo E, Cartoni Mancinelli A, Rende M, Stabile AM, Pistilli A.

(5) In vitro effect of nerve growth factor on the main traits of rabbit spermReproductive biology and endocrinology : RB&ENovember 12, 2019Castellini C, Mattioli S, Dal Bosco A, Collodel G, Pistilli A, Stabile AM, Macchioni L, Mancuso F, Luca G, Rende M.and semen traits: We carried out preliminary trials to define the suitable doses of TrKA antibody (AF175 R&D Systems, MN, USA; from 8 to 50 μg/mL) and p75NTR antibody (Me20.4 Monoclonal Antibody Millipore,

(6) Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkACell reportsMarch 26, 2019Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, et al.

(7) Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem CellsScientific reportsJanuary 12, 2018Alshawaf AJ, Viventi S, Qiu W, D'Abaco G, Nayagam B, Erlichster M, Chana G, Everall I, Ivanusic J, Skafidas E, et al.ab20670), mouse anti-rat NF200 (1:2000, Sigma Aldrich, N0142), goat anti-human TRKA (1:200, R&D Systems, AF175), rabbit anti-human TRPV1 (1:500, Alomone Labs, ACC-030), goat anti-mouse TRKB (1:500, R&D Systems,

(8) TrkA is a binding partner of NPM-ALK that promotes the survival of ALK⁺ T-cell lymphomaMolecular oncologySeptember 1, 2017Shi W, George SK, George B, Curry CV, Murzabdillaeva A, Alkan S, Amin HM.R&D Systems, Minneapolis, MN, USA) was added with or without 5 μg·mL−1 anti‐TrkA‐neutralizing antibody (AF175; R&D Systems). 2.2 Small‐molecule TrkA inhibitor (TrkAi) Selective targeting of TrkA was achieved

(9) TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cellsOncotargetAugust 2, 2016Pinet S, Bessette B, Vedrenne N, Lacroix A, Richard L, Jauberteau MO, Battu S, Lalloué F.HSP90 (ab13492, 1/1000), TSG101 (ab30871, 1/1000) were obtained from Abcam. Antibodies against TrkA (AF175, 1/200) TrkB (MAB397, 1/200), TrkC(AF1404, 1/200) and P75NTR (AF1157, 1/1000) were purchased from R&D System

(10) Nerve growth factor downregulates inflammatory response in human monocytes through TrkAJournal of immunology (Baltimore, Md. : 1950)April 1, 2014Prencipe G, Minnone G, Strippoli R, De Pasquale L, Petrini S, Caiello I, Manni L, De Benedetti F, Bracci-Laudiero L.

(11) Characterization of neuronal populations in the human trigeminal ganglion and their association with latent herpes simplex virus-1 infectionPloS oneJanuary 1, 2013Flowerdew SE, Wick D, Himmelein S, Horn AK, Sinicina I, Strupp M, Brandt T, Theil D, Hüfner K.mouse monoclonal to Ret (Ret01), ab1840, Abcam, Cambridge, UK, used at 1:10; goat polyclonal to TrkA, AF175, R&D Systems, Wiesbaden, Germany, used at 1:50; rabbit polyclonal to nNOS, AB5380, Merck Millipore,

(12) Age-related regional differences in cardiac nerve growth factor expressionAge (Dordrecht, Netherlands)June 1, 2012Saygili E, Kluttig R, Rana OR, Saygili E, Gemein C, Zink MD, Rackauskas G, Weis J, Schwinger RH, Marx N, et al.following primary antibodies were used: rabbit anti-NGF (Santa Cruz, sc-548), goat anti-TrkA (R&D Systems, AF175), rabbit anti-GAPDH (Cell Signaling, #2118), mouse anti-PGP9.5 (Abcam, ab20559), rabbit anti-neurofilament

(13) TrkB antibody elicits cytotoxicity and suppresses migration/invasion of transitional cell carcinoma cellsInternational journal of oncologyOctober 1, 2010Huang YT, Lai PC, Wu CC, Cheng CC, Chiu TH.designation was the same as cell growth assay. Different concentrations (1 or 3 μg/ml) of TrkA Ab (AF175, R&D Systems, Minneapolis, MN), TrkB Ab (sc-8316, Santa Cruz), or TrkC Ab (AF373, R&D Systems) were

(14) BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cellsInternational journal of oncologyJune 1, 2010Huang YT, Lai PC, Wu CC, Hsu SH, Cheng CC, Lan YF, Chiu TH.(sc-546, Santa Cruz Biotechnology Inc., Santa Cruz, CA), anti-TrkB (sc-8316, Santa Cruz), anti-TrkA (AF175, R&D Systems), and anti-TrkC (AF373, R&D Systems) were used. Exclusion of primary antibody was used as

(15) Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphomaExperimental hematologyNovember 1, 2009Sniderhan LF, Garcia-Bates TM, Burgart M, Bernstein SH, Phipps RP, Maggirwar SB.

(16) In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root gangliaStem cells translational medicineJanuary 1, 0001"Viventi S, Frausin S, Howden SE, Lim SY, Finol-Urdaneta RK, McArthur JR, Abu-Bonsrah KD, Ng W, Ivanusic J, Thompson L, et al."Millipore, MAB352), TRPV1 (rabbit, 1:1000, Novus Biologicals, NB120‐3487), hTRKA (goat, 1:200, R&D systems, AF175), hTRKB (mouse, 1:200, Novus Biologicals, NBP1‐47898), TRKB (mouse, 1:500, R&D systems, AF1494), hTRKC

(17) Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory NeuronsFrontiers in cellular neuroscienceJanuary 1, 0001"Hulme AJ, McArthur JR, Maksour S, Miellet S, Ooi L, Adams DJ, Finol-Urdaneta RK, Dottori M."

(18) Generation of self-organized autonomic ganglion organoids from fibroblastsiScienceJanuary 1, 0001"Liu S, Xiang K, Yuan F, Xiang M."Diagnostic Antibodies,"Cat# AS-5656S,RRID:AB_2925165" Goat polyclonal anti-TrkA,R&D Systems,"Cat# AF175, RRID:AB_354970" Goat polyclonal anti-TrkC,R&D Systems,"Cat# AF1404, RRID:AB_2155412" Mouse monoclonal

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TrkA Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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TrkA Antibody from R&D Systems, a Bio-Techne Brand

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