TGF-beta RII Antibody AF532 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemTGF-beta RII Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAF532
NCBI Gene AliasesRIIDN, TbetaR-II, 1110020H15Rik, TBR-II, TbetaRII, DNIIR
ApplicationsWestern Blot, Flow Cytometry, CyTOF-ready
ReactivityMouse
IsotypeIgG
Quantity100 ug (also 25 ug)
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
TargetTGF-beta RII
Conjugate/TagUnconjugated
HostGoat
NCBI Full Gene Nametransforming growth factor, beta receptor II
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse TGF-beta RII and S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TGF-beta RII, Ile24-Asp184, Accession # Q62312
ConcentrationLYOPH
Brand/TrademarkR&D Systems, a Bio-Techne Brand
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects mouse TGF-beta RII in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human (rh) TGF-beta RII is observed

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in miceFront ImmunolDecember 11, 2023Johnson Q. Tran, Marcus O. Muench, Betty Gaillard, Orsolya Darst, Mary M. Tomayko, Rachael P. Jackman(C12), CD38-BUV563 (90/CD38), IgM-BUV615 (II/41), CD23-BUV395 (B3B4) and IgD-BUV496 (AMS9.1) (BD); B220-AF532 (RM0063-9F14, Novus Biologicals); and CD73-AF750 (496406, R&D Systems). To exclude non-B cells, the

(2) B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reactionAging cellSeptember 1, 2022Lee JL, Fra-Bido SC, Burton AR, Innocentin S, Hill DL, Linterman MA.anti‐human CD27,BD (L128),563816,1:2000 8,BUV737‐coupled anti‐human CD10,BD (HI10a),741825,1:1000 9,AF532‐coupled anti‐human IgM,NOVUS (IM373),NBP2‐34650AF532,1:1000 10,SparkBlue574‐coupled anti‐human CD3,BioLegend

(3) Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trialNature medicineJune 1, 2022Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A, Fossati-Jimack L, Thorborn G, et al.previously described49. Briefly, tissue morphology was visualized using fluorescent antibodies CD68-AF532 (clone KP1, Novus), CD20-DL594 (clone IGEL/773, Novus) and CD3-AF647 (clone UMAB54, Origene) and Syto13

(4) Using the Autofluorescence Finder on the Sony ID7000^TM Spectral Cell Analyzer to Identify and Unmix Multiple Highly Autofluorescent Murine Lung PopulationsFrontiers in bioengineering and biotechnologyJanuary 1, 2022Wanner N, Barnhart J, Apostolakis N, Zlojutro V, Asosingh K.Factor,Polyclonal,AF647,Dako/Novus,A0082/336-0005,1/400,1/300 CD90.2,Thy-1.2,53–2.1,BV421,BioLegend,140327,1/800,1/800 α-SMA,ACTA2,1A4,APC,Biotium,BNCA0665-250,1/800,1/800 MUC2,Mucin 2,996/1,PE,Novus,NB120-11197PE,1/200,1/75 Ly-6G,Lymphocyte antigen 6 complex,1A8,AF532,Novus,NBP2-53131AF532,1/800,1/800 Siglec-F,Siglec-5,E50-2440,BV750,BD,747316,1/400,1/400 CD11c,ITGAX,N418,BB700,BD,745852,1/400,1/400 CD24,Heat

(5) Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma modelJournal for ImmunoTherapy of CancerMarch 11, 2021Tereza Andreou, Jennifer Williams, Rebecca J Brownlie, Robert J Salmond, Erica Watson, Gary Shaw, Alan Melcher, Heiko Wurdak, Susan C Short, Mihaela Lorgerby western blot as previously described,17 using anti-mouse TGFβ RII primary antibody (R&D Systems, AF532) and secondary anti-goat HRP antibody (Invitrogen). Anti-actin antibody (Sigma A1978) was used as a

(6) Development of syngeneic murine cell lines for use in immunocompetent orthotopic lung cancer modelsCancer cell internationalJanuary 1, 2020Nolan K, Verzosa G, Cleaver T, Tippimanchai D, DePledge LN, Wang XJ, Young C, Le A, Doebele R, Li H, et al.antibodies: KRASG12D (Cell Signaling #14429 1:1000), SMAD4 (Abcam #ab40759 1:5000), TGFBR2 (R&D Systems #AF532), TP53 (Cell Signaling #32532 1:1000), PTEN (Cell Signaling #9559 1:1000), MAP3K7 (Cell Signaling #4505

(7) Bone morphogenetic protein and activin membrane-bound inhibitor suppress bone cancer progression in MG63 and SAOS cells via regulation of the TGF-β-induced EMT signaling pathwayOncology lettersOctober 1, 2018Liu F, Wang K, Zhang L, Yang YL.ab51243; Abcam); B-cell lymphoma 2 (1:1,000; Bcl-2; cat. no. ab692; Abcam); TGF-β (1:1,000; cat. no. AF532; R&D Systems); epithelial (E)-cadherin (1:200; cat. no. NBP238856; Novus Biologicals LLC, Littleton,

(8) miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signalingNature communicationsJune 20, 2018Lam J, van den Bosch M, Wegrzyn J, Parker J, Ibrahim R, Slowski K, Chang L, Martinez-Høyer S, Condorelli G, Boldin M, et al.(Santa Cruz Biotechnology; 376838, 1:1000), p38 (9212; Cell Signaling, 1:500), TGFβ RII (R&D Systems; AF532, 1:400), RBPMS (Santa Cruz Biotechnology; 293285, 1:400), SARA (LifeSpan Biosciences; C410575, 1:400),

(9) Bone morphogenetic protein and activin membrane-bound inhibitor overexpression inhibits gastric tumor cell invasion via the transforming growth factor-β/epithelial-mesenchymal transition signaling pathwayExperimental and therapeutic medicineJune 1, 2018Yuan CL, Liang R, Liu ZH, Li YQ, Luo XL, Ye JZ, Lin Y.BAMBI (1:500; cat. no. AF2387; R&D Systems, Inc., Minneapolis, MN, USA), TGF-β, (1:1,000; cat. no. AF532; R&D Systems, Inc.) SNAI1 (1:500; cat. no. PAB29288; Abnova Corporation, Taipei, Taiwan), α-actin-2

(10) miR-17∼92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signalingProceedings of the National Academy of Sciences of the United States of AmericaDecember 20, 2016Fedeli M, Riba M, Garcia Manteiga JM, Tian L, Viganò V, Rossetti G, Pagani M, Xiao C, Liston A, Stupka E, et al.

(11) Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1Proceedings of the National Academy of Sciences of the United States of AmericaMarch 3, 2015Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, et al.

(12) Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attritionThe Journal of clinical investigationJune 1, 2014Bhadra R, Moretto MM, Castillo JC, Petrovas C, Ferrando-Martinez S, Shokal U, Leal M, Koup RA, Eleftherianos I, Khan IA.

(13) Augmented cytoplasmic Smad4 induces acceleration of TGF-beta1 signaling in renal tubulointerstitial cells of hereditary nephrotic ICGN mice with chronic renal fibrosis; possible role for myofibroblastic differentiationCell and tissue researchFebruary 1, 2004Goto Y, Manabe N, Uchio-Yamada K, Yamaguchi-Yamada M, Inoue N, Yamamoto Y, Ogura A, Nagano N, Miyamoto H.

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TGF-beta RII Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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TGF-beta RII Antibody from R&D Systems, a Bio-Techne Brand

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