PDGF-C Antibody AF1447 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemPDGF-C Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF1447
NCBI Gene AliasesSCDGF, 1110064L01Rik, FALLOTEIN, VEGF-E, PDGF-C
ApplicationsImmunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,In vivo assay,Neutralization
ReactivityHuman,Mouse,Rat,Transgenic Mouse
IsotypeIgG
Conjugate/TagUnconjugated
HostGoat
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Quantity100 ug (also 25 ug)
TargetPDGF-C
NCBI Full Gene Nameplatelet-derived growth factor, C polypeptide, platelet derived growth factor C
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant mouse PDGF-CC, Val235-Gly345, Accession # Q8CI19
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse PDGF-C in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human (rh) PDGF-CC is observed and less than 1% cross-reactivity with rhPDGF-AA, rhPDGF-BB, rhPDGF-D, and recombinant rat PDGF-AB is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progressionScience advancesNovember 5, 2021Opzoomer JW, Anstee JE, Dean I, Hill EJ, Bouybayoune I, Caron J, Muliaditan T, Gordon P, Sosnowska D, Nuamah R, et al.(57), and mice were intraperitoneally injected with 100 μg of a goat anti–PDGF-C neutralizing antibody (AF1447, Bio-Techne) solubilized in PBS on days −2 and −1 before analysis. Murine tissue staining Mouse mammary

(2) Glycosylation at Asn254 Is Required for the Activation of the PDGF-C ProteinFrontiers in molecular biosciencesJanuary 1, 2021Hu W, Zhang R, Chen W, Lin D, Wei K, Li J, Zhang B, Li X, Tang Z.after incubation. Primary antibodies included goat anti-PDGF-C (core domain; 1:1,000, R&D Systems, AF1447), rabbit anti-ZsGreen (1:1,000, Takara, 632,474), rabbit anti-p-PDGFRα Tyr762 (1:1,000, Cell Signaling

(3) PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficientlyOncotargetNovember 22, 2016Zheng L, Zhao C, Du Y, Lin X, Jiang Y, Lee C, Tian G, Mi J, Li X, Chen Q, et al.

(4) The PDGFC CUB Domain Enhances Survival in PDGFC Mutant MiceSOJ ImmunologySeptember 14, 2015Jean S Campbelldescribed [25]. For PDGF-C detection membranes were incubated with goat anti-mouse PDGF-C antibody (1:1000, AF1447 R&D Systems) followed by incubation with an anti-goat Horseradish Peroxidase (HRP) conjugated secondary

(5) Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in miceDisease models & mechanismsNovember 1, 2013Wiradjaja F, Cottle DL, Jones L, Smyth I.anti-laminin γ1 A5 MAB1914P −IF (Millipore, Billerica, MA), goat anti-TIMP1 AF980 −WB, goat anti-PDGFC AF1447 −WB (R&D System, Minneapolis, MN), goat anti-PDGFC (C-17) sc-18228 −IF (Santa Cruz Biotechnology, Dallas,

(6) Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylationThe Journal of experimental medicineApril 12, 2010Tang Z, Arjunan P, Lee C, Li Y, Kumar A, Hou X, Wang B, Wardega P, Zhang F, Dong L, et al.

(7) PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatmentCancer cellJanuary 6, 2009Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N.

(8) Platelet-derived growth factor isoform expression in carbon tetrachloride-induced chronic liver injuryLaboratory investigation; a journal of technical methods and pathologyOctober 1, 2008Borkham-Kamphorst E, Kovalenko E, van Roeyen CR, Gassler N, Bomble M, Ostendorf T, Floege J, Gressner AM, Weiskirchen R.was achieved through goat anti-PDGF-A (AF1055), rabbit anti-PDGF-B (Abcam), goat anti-mouse PDGF-C (AF1447; R&D Systems) and rabbit anti-human 1091 PDGF isoform expression in chronic CCl4 rat livers E Borkham-Kamphorst

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PDGF-C Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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PDGF-C Antibody from R&D Systems, a Bio-Techne Brand

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