Mouse PDGF Rß Antibody AF1042 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMouse PDGF Rß Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog NumberAF1042
NCBI Gene AliasesCD140b, Pdgfr, PDGFR-1
ApplicationsConfocal Imaging,IHC-F,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,Dual RNAscope ISH-IHC Compatible
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Quantity100 ug (also 25 ug)
ReactivityHuman,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Rat,Transgenic Mouse
TargetPDGF R beta
HostGoat
IsotypeIgG
NCBI Full Gene Nameplatelet derived growth factor receptor, beta polypeptide
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse PDGF Rß, Leu32-Lys530, Accession # P05622
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Questions and Answers

Can this antibody be used to study PDGFRβ in mouse models, and what evidence supports its use?

Yes, the PDGF R beta Antibody has been shown to work effectively in mouse models. For instance, in a study investigating pericyte migration and neovascularization in ischemic retinopathy, the antibody was utilized to detect PDGFRβ expression in immunohistochemical analyses, confirming its applicability in mouse tissues ().

Is this antibody suitable for use in immunofluorescence applications, and how has it been validated in the literature?

The PDGF R beta Antibody has been successfully used in immunofluorescence applications, as evidenced by its inclusion in studies where it was employed to visualize PDGFRβ in various cellular contexts, including endothelial cells and pericytes (, ).

What species can this antibody detect, and how does its specificity compare across different species?

This antibody detects PDGFRβ in multiple species, including mouse, rat, human, and non-human primates. It shows approximately 35% cross-reactivity with recombinant human PDGF Rβ in direct ELISAs, indicating its utility across species while maintaining specificity for mouse PDGFRβ ().

Are there any notable applications of this antibody in cancer research?

Yes, the PDGF R beta Antibody has been utilized in cancer research, particularly in studies examining glioblastoma. It was shown to play a role in the resistance of glioblastoma to anti-VEGF treatment, highlighting the importance of PDGFRβ signaling in tumor-associated endothelial cells ().

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Depletion of BIS in astrocytes aggravates reactive gliosis following photothrombotic brain injuryThe Korean Journal of Physiology & PharmacologyMay 1, 2026Soon-Young Jung, Ji-Won Hwang, Hye Hyeon Yun, Kyunghyun Yoo, Hong Lim Kim, Yuna Oh, Sung Won Jung, Joo Youn Kim, Sun-Nyoung Hwang, Seong Yun Kim, et al.ab24170), mouse anti-nestin (1:500, AbD Serotec, 6625-1010), goat anti-PDGFR-β (1:100, R&D systems, AF1042), and mouse anti-p62 (1:100, Abcam, ab56416). On the next day, sections were incubated with appropriate

(2) Co-Delivery of Synaptogenic and Angiogenic Nanoparticles in MAP Scaffolds Enhances Post-Stroke Synapse FormationJournal of Materials Chemistry BFebruary 25, 2026Nhi Van Phan, Jeremy Lee Thomas, Aiden Pasinsky, Zoe Meadows, Ting Ting Li, Augustus Adams, Yike Zhu, Anna Edgcomb, Yi Shi, Sihan Lyu, et al.from light. Primary antibodies: 1 : 250 NF200 (Millipore-Sigma, N4142), 1 : 250 PDGFRβ (R&D Systems, AF1042), 1 : 500 CD31 (BD, 557355), 1 : 1000 vGlut1 (Guinea Pig, AB5905), 1 : 250 Homer (Synaptic Systems,

(3) TGF-β-induced fibrotic scar formation limits recovery of spinal cord injuryBone ResearchFebruary 25, 2026Dayu Pan, Panfeng Wu, Kathleen Noller, Patrick Cahan, Xu CaoPhospho SAMD2 (1:100, 44-244 G, Invitrogen), rabbit PDGFR-β (1:100, ab32570, Abcam), goat PDGFR-β (1:100, AF1042, R&D Systems), rabbit FSP1 (1:300, 07-2274, MilliporeSigma, Burlington, MA, USA), and chicken green

(4) GLP-1 activates KATP channels in coronary pericytes as the effector of brain-gut-heart signalling mediating cardioprotectionNature CommunicationsFebruary 14, 2026Svetlana Mastitskaya, Felipe Santos Simões de Freitas, Lowri E. Evans, David Attwellinto 150 µm transverse sections. The labelling was done using anti-PDGFRß antibodies (R&D Systems, AF1042, 1:50) for pericytes, isolectin GS-IB4-biotinylated (Life Technologies, 121414, 1:200) for capillary

(5) Adult leptomeningeal vestigial neural crest-derived multipotent cells promote vascular repair after strokeCell ReportsJanuary 27, 2026Yoshihiko Nakamura, Takafumi Nakano, Lluis Alzamora-Llull, Ji-Hyun Park, Masayoshi Tanaka, Ester Licastro, Damian Panas, Shin Ishikane, Dong-Bin Back, Gen Hamanaka, et al.LS-C356037–100 Mouse anti beta actin,Millipore-Sigma,Cat# A5441 Mouse anti PDGFRbeta,R&D Systems,Cat# AF1042; RRID:AB_2162633 Rabbit anti alpha SMA,Abcam,Cat# ab5694; RRID:AB_2223021 Rabbit anti AP-2alpha,Thermo Fisher Scientific

(6) RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular DystrophyAdvanced ScienceDecember 22, 2025Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, et al.(553373, BD Pharmingen, 1:200), anti‐α7 integrin (produced in‐house, diluted 1:200) and anti‐PDFGR (AF1042, R&D Systems, diluted 1:100). CD31 (‐), α7 integrin (‐) and PDFGR (+) cells were identified as FAPs,

(7) Modular de- and re-construction of vascularized osteochondral tissues in an Organ-on-Chip dual-compartment platformJournal of Orthopaedic TranslationNovember 27, 2025Andrea Mainardi, Andrea Barbero, Martin Ehrbar, Marco Rasponi, Ivan Martin, Paola Occhetta(OPN, Proteintech, 22952-1, 1:200), platelet-derived growth factor receptor beta (PDGFRB, R&D Systems, AF1042, 1:200), and nestin (Millipore, MAB5326, 1:200). Bone sialoprotein (BSP, Abcam, ab52128, 1:200), laminin

(8) Fzd2 orchestrates canonical and non-canonical Wnt signaling to regulate lung development and fibrosisCell Communication and SignalingNovember 19, 2025Jiayu Zhou, Xiayuan Lou, Zichen Wei, Xuhua Mao, Jingbo Zhang, Xiaoye Jin, Bo Li, Chao Zheng, Xuerong Siwu, Yi Yang, et al.anti-cleaved caspase 3 (1:200, 9664S, Cell Signaling), PDGFRa (1:200, ab203491, Abcam), PDGFRb (1:200, AF1042, R&D Systems). Biotinylated or fluorescent secondary antibodies were used for detection and visualization.

(9) Neuronal MCT2 promotes angiogenesis via lactate in the developing mouse neocortexCell death and differentiationOctober 4, 2025Lee D, Wu A, Yao L, Satish S, Mei L, Xiong WC.rat monoclonal anti-Ki67 (Synaptic Systems, HS-398 117); goat polyclonal anti-PDGFRβ (R&D Systems, AF1042); mouse anti-Glut1 (Millipore sigma, MABS132); mouse monoclonal anti-Oilg2 (EMD Millipore, MABN50);

(10) Impaired capillary-venous drainage contributes to gliosis and demyelination in mouse white matter during agingNature neuroscienceSeptember 1, 2025Stamenkovic S, Schmid F, Gurler G, Abolmaali F, Weitermann NA, Takasaki KT, Bonney SK, Sosa MJ, Bennett HC, Kim Y, et al.

(11) The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactionsNeuronAugust 20, 2025Wu L, Pandey V, Casha VH, Qu Z, Jami-Alahmadi Y, Gradinaru V, Wohlschlegel JA, Khakh BS.390–004); rabbit anti-Atp1a2 (1:300, Alomone labs, ANP-002); goat anti-Pdgfrb (1:300, R&D systems, AF1042); rabbit anti-Pdgfra (1:400, R&D systems, AF1062); rabbit anti-Olig2; rabbit anti-Ibal1 (1:500, Wako,

(12) Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic neuropathic painNeuronJune 4, 2025Wenrui Xie, Debora Denardin Lückemeyer, Katherine A. Qualls, Arthur Silveira Silveira Prudente, Temugin Berta, Mingxia Gu, Judith A. Strong, Xinzhong Dong, Jun-Ming Zhang435/455 blue catalog N21479). PDGFRβ antibody used to label pericytes was from R&D Systems (Cat #: AF1042). Quantitative PCR Mice were deeply anaesthetized with pentobarbital sodium and transcardially perfused

(13) Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblastsbioRxivMay 29, 2025Maria Jose Gacha-Garay, Hui Liu, Scott E Evans, Tingting W Mills, Jichao ChenA30634, Thermo Fisher), rat anti-PDGFRA, (1:1000, 14–1401-82, eBioscience), goat anti-PDGFRB (1:1000, AF1042, R&D systems), rat anti-PDGFRB (1:1000 R&D systems AF2419), rabbit anti-TAGLN (1:1000, ab14106, Abcam),

(14) Optimized enrichment of murine blood-brain barrier vessels with a critical focus on network hierarchy in post-collection analysisSci RepMay 6, 2025Hanaa Abdelazim, Audra Barnes, James Stupin, Ranah Hasson, Carmen Muñoz-Ballester, Kenneth L. Young, Stefanie Robel, James W. Smyth, Samy Lamouille, John C. ChappellAnti-mouse Claudin5,Invitrogen,Cat. #34–1600 Polyclonal Goat IgG Anti-mouse PDGF Receptor-β,Biotechne,Cat. #AF1042 Polyclonal Rat IgG Anti-mouse PDGF Receptor-β,Invitrogen,Cat. #14–1402− 82 Monoclonal Mouse IgG Anti-mouse

(15) Meflin/Islr is a marker of fibroblasts that arise in fibrotic regions after spinal cord injuryNagoya J Med SciMay 1, 2025Yoshinori Morita, Yukihiro Shiraki, Akira Kato, Yasuhiro Nagatani, Ryota Ando, Hiroaki Nakashima, Shiro Imagama, Atsushi Enomoto13-0300, Invitrogen, Carlsbad, CA, USA), or mouse anti-PDGFRβ antibody (polyclonal, dilution 1:1000, AF1042, R&D Systems, Minneapolis, MN, USA) overnight at 4 °C. After washing, the slides were incubated with

(16) Notch signaling in osteoblast progenitor cells is required for BMP-induced bone formationBoneMay 1, 2025Heather M. Wilson, Madison A. Buckles, Parker K. Acevedo, Christina Capobianco, Danny M. Nguyen, Karen Kessell, Ingrid L. Bergin, Yadav Wagley, Ivo Kalajzic, Kurt D. Hankensonconventional, qualitative bright-field light microscopy. Immunostaining was performed for PDGFRβ (R&D Systems AF1042, 1:250), F4/80 (Abcam ab300421, 1:100), CD31 (Abcam ab222783, 1:100), and Ly6G (Abcam ab25377, 1:100).

(17) A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during developmentCell ReportsApril 22, 2025Hongbo Wen, Prashant Chandrasekaran, Annabelle Jin, Josh Pankin, MinQi Lu, Derek C. Liberti, Jarod A. Zepp, Rajan Jain, Edward E. Morrisey, Sylvia N. Michki, et al.antibody,HistoBio Tec,DIA-310; RRID: AB_2631039 Goat polyclonal Anti-PDGF Receptor beta antibody,R&D Systems,AF1042; RRID: AB_2162633 Rabbit monoclonal Anti-PDGF Receptor alpha antibody,Cell Signaling,3174S; RRID: AB_2162345 "Donkey

(18) LRG1 Alters Pericyte Phenotype and Compromises Vascular MaturationCellsApril 14, 2025Alexandra E. Hoeh, Jui-Hsien Chang, Ronja S. Mueller, Mark Basche, Alessandro Fantin, Anastasios Sepetis, Giulia De Rossi, Athina Dritsoula, Robin R. Ali, Patric Turowski, et al.anti-occludin Alexa Fluor® 594 conjugate (331594, Thermofisher Scientific) and goat polyclonal anti-PDGFRβ (AF1042, R&D systems). Retinas were then incubated with the appropriate secondary antibodies Alexa Fluor® 488,

(19) Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelinationJ NeuroinflammationApril 7, 2025Zeeba Manavi, George S. Melchor, Meghan R. Bullard, Phillip S. Gross, Shinjini Ray, Pankaj Gaur, Maryna Baydyuk, Jeffrey K. Huang(Abcam, ab54210, 1:500), mouse anti-p21 (Santa Cruz, sc6246, 1:500), goat anti-PDGFRβ (R&D systems, AF1042, 1:200), rat anti-CD3 (eBioscience, 14–0032-85, 1:100), rat anti-B220 (Invitrogen, 14–0452-81, 1:100),

(20) Administration of Noggin Suppresses Fibrinogen Leakage into the Brain in the Acute Phase After Traumatic Brain Injury in MiceInternational journal of molecular sciencesMarch 25, 2025Yasunaga M, Takata F, Iwao T, Mizoguchi J, Tajima N, Dohgu S.Clara, CA, USA), rabbit anti-BMP4 (1:400 #ab39973 Abcam, Cambridge, UK), goat anti-PDGFRβ (1:100, #AF1042; R&D Systems), rabbit anti-GFAP (1:500, #AB5804; Merck Millipore, Burlington, MA, USA), rabbit anti-Iba1

Write a Review

(1)

11/29/2016Pericyte Staining In Mouse Skin Lin ChenThe aim is to stain mouse skin pericytes. This antibody seems to work. However, the other cells in the skin also were stained. If you are looking for an antibody just for pericytes in mouse skin, it ... Read Review

PDGF R beta Antibody

PDGF R beta Antibody

PDGF R beta Antibody

PDGF R beta Antibody

Mouse PDGF Rß Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

Questions and Answers

R&D Systems, a Bio-Techne Brand

Citations (147)

Reviews

Mouse PDGF Rß Antibody from R&D Systems, a Bio-Techne Brand

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map