TROP-2 Antibody AF1122 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemTROP-2 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF1122
NCBI Gene AliasesM1S1, TROP2, EGP-1, EGP1, GA733-1, GA7331, Ly97, GP50
ApplicationsFlow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry,CyTOF-ready
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
TargetTROP-2
Quantity100 ug (also 25 ug)
ReactivityMouse,Transgenic Mouse
HostGoat
NCBI Full Gene Nametumor associated calcium signal transducer 2, tumor-associated calcium signal transducer 2
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant mouse TROP-2, Ser82-Thr268, Accession # Q8BGV3
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse TROP-2 in direct ELISAs and Western blots. In direct ELISAs, less than 30% cross-reactivity with recombinant human TROP-2 is observed.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Paired mutation calling and spatial transcriptomics identify cellular neighborhoods associated with the neoplastic outcome of mouse colitisNat GenetJuly 28, 2026Elisa B. Moutin, Linus L. H. Chang, Giada Giavara, Shenay Mehmed, Mathilde Colombé, Carla Boquetale, Kate Marks, Filipe C. Lourenço, Nefeli Skoufou-Papoutsaki, Richard Kemp, et al.(1:100, chicken, ab13970, Abcam), E-cadherin (1:200, mouse, 610182, BD Biosciences), Trop2 (1:100, goat, AF1122, R&D systems) and Arid1a (1:100, rabbit, 12354S, Cell Signaling) were diluted in blocking solution,

(2) KLF4 Promotes a KRT13+ Hillock-Like State in Lung Squamous Cell CarcinomaCancer ResJune 18, 2026Luke T. Izzo, Tony Reyes, Srijan Meesala, Abbie S. Ireland, Lisa B. Earnest-Noble, Steven Yang, Hari Shankar Sunil, Xiao Chun Cheng, Nomi Tserentsoodol, Sarah B. Hawgood, et al.AF3158, RRID: AB_2130245); 1:200 LGALS3 (CST Cat # 89572, RRID:AB_3716630); 1:100 TROP2 (R&D System Cat # AF1122, RRID: AB_2205662). Quantification of percent positive cells was performed on non-overlapping images

(3) A New Model of Gastric Pre-neoplasia Induced by Aberrant ADAR1-mediated Double-stranded RNA SignalingCellular and molecular gastroenterology and hepatologyJanuary 1, 2026Halstead AM, Nwokolo C, Hoft S, Yu J, Zhu L, Tuley B, Vargas N, Liu R, Victorino FR, Phatak S, et al.simplicifolia (GSII)-488,Invitrogen,L21415 "Anti-Ki-67, rabbit",Abcam,ab15580 "Anti-TROP2, goat",R&D Systems,AF1122 "Anti-ARID1A, rabbit",Cell signaling,12354S "Anti-Phospho-MLKL, rabbit",Abcam,ab196436 "K1 anti-dsRNA,

(4) Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoidsNat CommunJuly 17, 2025Hiroaki Ayabe, Erica A. K. DePasquale, Surya P. Amarachintha, Reena Mourya, Wenqi Li, Shreya Nalluri, Sejal R. Fox, Kenichiro Konishi, Pranavkumar Shivakumar, Jorge A. Bezerraantibody (R and D Systems, AF960) were used. For mouse, goat anti-mouse TROP2 antibody (R and D systems, AF1122) and rat anti-mouse EPCAM antibody (BD Bioscience, 552370) were used. Specific antibody details are

(5) Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitisResearch squareMay 8, 2025Moutin EB, Chang L, Giavara G, Mehmed S, Colombé M, Lourenço FC, Skoufou-Papoutsaki MN, Kemp R, Gascard P, Tlsty T, et al.(1:100, chicken, ab13970, Abcam), E-cadherin (1:200, mouse, 610182, BD Biosciences), Trop2 (1:100, goat, AF1122, R&D systems) and Arid1a (1:100, rabbit, 12354S, Cell Signalling) were diluted in blocking solution,

(6) CDX2 downregulation regulates intrinsic WNT pathway activation, dictating metastasis in APC and CTNNB1 wildtype colorectal cancerOncogeneApril 6, 2025Valérie M. Wouters, Roxan F. C. P. A. Helderman, Kate Cameron, Sander R. van der Hooff, Arezo Torang, Saskia van den Bergh, Rene Jackstadt, Owen J. Sansom, Sanne M. van Neerven, Jan Paul Medema640 nm laser. LY6a (1:10.000, PE-conjugated, 12-5981-82, Thermo Fisher Scientific) and TROP2 (1:1000, AF1122, R&D systems, Minneapolis, MN, USA) + anti-Goat IgG (1:500, PE-conjugated, F0107, R&D systems) expression

(7) p53-loss induced prostatic epithelial cell plasticity and invasion is driven by a crosstalk with the tumor microenvironmentCell death & diseaseJanuary 26, 2025Yanushko D, German Falcon B, El Bizri R, Pervizou D, Dolgos R, Keime C, Ye T, Thibault-Carpentier C, Le Magnen C, Henri S, et al.1:200), p21 (BD Pharmingen, 556430, 1:50), pAkt (S473) (D9E) XP (CST, 5315S; 1:200), Trop2 (R&D Systems, AF1122; 1:50), Ki-67 (Thermo Fisher Scientific, MA5-14520; 1:200), E-cad (CST, 14472S; 1:200), Vim (CST, 5741S;

(8) Phylogenetic conservation of Trop-2 across species—rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarksFrontiers in GeneticsJanuary 5, 2024Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Khouloud Boujnah, Nicole Travali, Antonino Moschella, Paolo Todaro, Laura Pierdomenico, Roberta Di Pietro, et al.1 M urea buffer pH 8.0. Sections were then incubated for 30 min with the AF650 anti-human Trop-2 or AF1122 anti-murine Trop-2 goat antiserum (R&D Systems). To control for non-specific reactivity, the specific

(9) ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancerScience advancesApril 5, 2023Li D, Zhan Y, Wang N, Tang F, Lee CJ, Bayshtok G, Moore AR, Wong EWP, Pachai MR, Xie Y, et al.Lysing Matrix A (MP Biomedicals). Immunofluorescence staining of Tacstd2/Trop2 (1:100 dilution; R&D Systems, AF1122), Col17a1 (1:100 dilution; Abcam, ab184996), and Ck5 (1:100 dilution; BioLegend, no. 905501) was performed

(10) TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and InvasivenessCancersAugust 26, 2022Švec J, Šťastná M, Janečková L, Hrčkulák D, Vojtěchová M, Onhajzer J, Kříž V, Galušková K, Šloncová E, Kubovčiak J, et al.Abcam, Cambridge, UK), anti-Trop2 (rabbit monoclonal, ab214488, Abcam), anti-Trop2 (goat polyclonal, AF1122, R&D Systems, Minneapolis, MN, USA), anti-vimentin (mouse monoclonal, #5741, Cell Signaling, Danvers,

(11) Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progressionScience advancesJuly 22, 2022Abu El Maaty MA, Terzic J, Keime C, Rovito D, Lutzing R, Yanushko D, Parisotto M, Grelet E, Namer IJ, Lindner V, et al.MA5-14520; dilution 1:200), Cxcl5 (Thermo Fisher Scientific, BS-2549R; dilution 1:200), TROP2 [R&D systems, AF1122; dilution 1:50 (immunofluorescence detection); Abcam, ab214488; dilution 1:200 (immunohistochemical

(12) Decoding the activated stem cell phenotype of the neonatally maturing pituitaryeLifeJune 14, 2022Laporte E, Hermans F, De Vriendt S, Vennekens A, Lambrechts D, Nys C, Cox B, Vankelecom H.Program (NHPP),RRID:AB_2629220,"(1:10,000)" Antibody,Anti-TACSTD2 (goat polyclonal),R&D systems,Cat. #:AF1122; RRID:AB_2205662,(1:50) Antibody,Anti-aGSU (guinea pig polyclonal),National Hormone and Peptide Program

(13) Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal MetaplasiaCellular and molecular gastroenterology and hepatologyJanuary 1, 2022Lee SH, Jang B, Min J, Contreras-Panta EW, Presentation KS, Delgado AG, Piazuelo MB, Choi E, Goldenring JR.HPA065008",1:500 TFF3,Rabbit,Gift from Daniel K. Podolsky (UT Southwestern),1:1000 Trop2 for mouse,Goat,"R&D Systems, AF1122",1:500 TROP2 for human,Goat,"R&D Systems, AF650",1:500 MUC5AC,Mouse,"NeoMarkers, MS-551-P",1:500 DEFA5,Mouse,"Santa Cruz

(14) Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesionsScience advancesJuly 1, 2021Abu El Maaty MA, Grelet E, Keime C, Rerra AI, Gantzer J, Emprou C, Terzic J, Lutzing R, Bornert JM, Laverny G, et al.following primary antibodies were used: phospho-Akt (S473) (CST 4060S; dilution 1:200), Trop2 (R&D Systems AF1122; dilution 1:50), cleaved caspase 3 (CST 9664; dilution 1:200), PCNA (Arigo Biolaboratories ARG62605;

(15) RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate developmenteLifeOctober 7, 2020Mevel R, Steiner I, Mason S, Galbraith LC, Patel R, Fadlullah MZ, Ahmad I, Leung HY, Oliveira P, Blyth K, et al.polyclonal),Proteintech,Cat: 17361–1-AP,IHC/IF (1:100) Antibody,Anti-TROP-2 (goat polyclonal),R and D Systems,Cat: AF1122 RRID:AB_2205662,IHC/IF (1:200) Antibody,Anti-BrdU (rat monoclonal),Abcam,Cat: ab6326 RRID:AB_305426,IHC/IF

(16) Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosaThe Journal of pathologyJuly 1, 2020Riera KM, Jang B, Min J, Roland JT, Yang Q, Fesmire WT, Camilleri-Broet S, Ferri L, Kim WH, Choi E, et al.hour at room temperature for blocking and incubated overnight at 4°C with Trop2 anti-goat (R&D systems AF1122, 1:2,000) and β-Actin anti-mouse (Sigma A5316, AC-74, 1:5,000) diluted in the Odyssey blocking solution

(17) High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell HomeostasisCell reportsFebruary 18, 2020Aros CJ, Paul MK, Pantoja CJ, Bisht B, Meneses LK, Vijayaraj P, Sandlin JM, France B, Tse JA, Chen MW, et al.

(18) Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophilsJournal of Clinical InvestigationDecember 3, 2019Karim Mahiddine, Adam Blaisdell, Stephany Ma, Amandine Créquer-Grandhomme, Clifford A. Lowell, Adrian ErlebacherBioLegend, rat monoclonal, clone I3/2.3); and TROP-2 (1:50, citrate; R&D Systems, goat polyclonal, catalog AF1122). After incubation with primary antibodies, the sections were incubated for 30 minutes at room temperature

(19) Expansion of Luminal Progenitor Cells in the Aging Mouse and Human ProstateCell reportsAugust 6, 2019Crowell PD, Fox JJ, Hashimoto T, Diaz JA, Navarro HI, Henry GH, Feldmar BA, Lowe MG, Garcia AJ, Wu YE, et al.

(20) Branching morphogenesis in the developing kidney is not impacted by nephron formation or integrationeLifeJuly 31, 2018Short KM, Combes AN, Lisnyak V, Lefevre JG, Jones LK, Little MH, Hamilton NA, Smyth IM.Fisher Thermo Fisher:13–1900; RRID:AB_86571 (1:400) Antibody Trop2 R and D Systems R and D Systems:AF1122; RRID:AB_2205662 (1:100) Antibody Six2 Proteintech Proteintech:115621AP; RRID:AB_2189084 (1:600) Commercial

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TROP-2 Antibody

TROP-2 Antibody

TROP-2 Antibody

TROP-2 Antibody

TROP-2 Antibody

TROP-2 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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TROP-2 Antibody from R&D Systems, a Bio-Techne Brand

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