LIF Antibody AB-449-NA from R&D Systems, a Bio-Techne Brand

Product Specs
ItemLIF Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $519.00Supplier Page View Company Product Page
Catalog NumberAB-449-NA
ApplicationsReference Standard,Immunohistochemistry,Western Blot,In vivo assay,Neutralization
Quantity1 mg
Conjugate/TagUnconjugated
ReactivityMouse,Transgenic Mouse
HostGoat
IsotypeIgG
TargetLIF
ClonalityPolyclonal
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose
ImmunogenE. coli-derived recombinant mouse LIF
ConcentrationLYOPH
PurityProtein A or G purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene NameLIF interleukin 6 family cytokine
NCBI Gene AliasesCDF, DIA, HILDA, MLPLI

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects mouse LIF in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant human LIF is observed. Neutralizes the biological activity of recombinant mouse LIF and will also neutralize the biological activity of recombinant human LIF at a 10-fold higher IgG concentration.

Sizes Available: 1 mg

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Prostaglandin E2-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinomaSignal Transduct Target TherApril 7, 2026Ling Wang, Qicai Liu, Zhibo Zhang, Shizhong Yang, Juan Tang, Guobin Pan, Yuqing Zheng, Yuting Zhuang, Qiming Wu, Shangeng Weng, et al.of either 200 μM CAY10526 (10 μL, MCE, HY-118119) or LIF neutralizing antibody (10 μL, R&D Systems, AB-449-NA) every three days for three weeks. Sciatic nerve function was assessed weekly via a hindlimb motor scoring

(2) The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF productionScience advancesJuly 21, 2023Kakae M, Nakajima H, Tobori S, Kawashita A, Miyanohara J, Morishima M, Nagayasu K, Nakagawa T, Shigetomi E, Koizumi S, et al.LIF-neutralizing antibody [10 μg; 1 mg/ml in phosphate-buffered saline (PBS); R&D Systems, catalog no. AB-449-NA] immediately after BCAS operation. Control groups were injected with a normal goat immunoglobulin G

(3) Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosisEBioMedicineDecember 1, 2022Xu S, Yang X, Chen Q, Liu Z, Chen Y, Yao X, Xiao A, Tian J, Xie L, Zhou M, et al.antibody. IgG (R&D Systems Cat# BAF108, RRID: AB_355828) or LIF-neutralizing antibody (R&D Systems Cat# AB-449-NA, RRID: AB_354362) was injected into mice via tail-vein injection. The dosage and time period of mice

(4) Neuroprotection against ischemic stroke requires a specific class of early responder T cells in miceThe Journal of clinical investigationAugust 1, 2022Cai W, Shi L, Zhao J, Xu F, Dufort C, Ye Q, Yang T, Dai X, Lyu J, Jin C, et al.1:200); goat polyclonal anti-CXCL11 (Alexa Fluor 572, R&D Systems; 1:200); goat polyclonal anti-LIF (AB449-NA, R&D Systems; 1:500); and rabbit polyclonal anti-GFAP (Z0334, Dako; 1:500). For neuronal apoptosis analysis,

(5) KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent stateJournal of hematology & oncologySeptember 16, 2021Lee JW, Hur J, Kwon YW, Chae CW, Choi JI, Hwang I, Yun JY, Kang JA, Choi YE, Kim YH, et al.immunoblotted with primary antibodies against KAI1 (catalog no. ab135779; Abcam), LIF (catalog no. AB-449-NA; R&D Systems), tSrc, pSrc (Tyr416), and pSrc (Tyr527) (Cell Signaling Technology), Myc (catalog no.

(6) Dihydroartemisinin attenuates osteoarthritis by inhibiting abnormal bone remodeling and angiogenesis in subchondral boneInternational journal of molecular medicineMarch 1, 2021Ma L, Zhao X, Liu Y, Wu J, Yang X, Jin Q.factor A (VEGFA) (1:100; product code ab52917; Abcam), leukemia inhibitory factor (LIF) (1:100; cat. no. AB-449-NA; R&D Systems, Inc.), sclerostin (1:50; product code ab63097; Abcam), β-catenin (1:100; cat. no. 51067-2-AP;

(7) Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State PluripotencyCell stem cellSeptember 3, 2020Skelly DA, Czechanski A, Byers C, Aydin S, Spruce C, Olivier C, Choi K, Gatti DM, Raghupathy N, Keele GR, et al.from 0.05–5000 pM. A control well containing 480 ng/ml of neutralizing anti-LIF antibody (R&D Systems AB-449-NA) was also plated. After 6 days cells were dissociated and the expression of mCherry was analyzed using

(8) Sclerostin expression in trabecular bone is downregulated by osteoclastsScientific reportsAugust 13, 2020Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, et al.phosphatase (ALP), tissue-non-specific antibody (ab108337, Abcam, Cambridge, UK), an anti-mouse LIF antibody (AB-449-NA, R&D Systems, Minneapolis, MN), anti-β-catenin antibody (ab32572, Abcam), or anti-mouse sclerostin antibody

(9) Osteoblast and Osteoclast Activity Affect Bone Remodeling Upon Regulation by Mechanical Loading-Induced Leukemia Inhibitory Factor Expression in OsteocytesFrontiers in molecular biosciencesJanuary 1, 2020Du J, Yang J, He Z, Cui J, Yang Y, Xu M, Qu X, Zhao N, Yan M, Li H, et al.anti-tartrate-resistant acid phosphatase (TRAP) antibody (ab185716, Abcam, United Kingdom) and anti-LIF antibody (AB-449-NA, R&D Systems, United States) was performed. 2 November 2020 | Volume 7 | Article 585056 Du et

(10) Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophyNature communicationsJune 26, 2019Welc SS, Flores I, Wehling-Henricks M, Ramos J, Wang Y, Bertoni C, Tidball JG.

(11) Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptinJCI insightJuly 26, 2018Arora GK, Gupta A, Narayanan S, Guo T, Iyengar P, Infante RE.monoclonal anti-pSTAT3 (catalog 9138) from Cell Signaling Technology; polyclonal anti-LIF (catalog AB-449-NA), polyclonal anti-gp130 (catalog AF468), and polyclonal anti–angiopoietin-like protein 2 (catalog AF1444)

(12) Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fateDevelopment (Cambridge, England)October 15, 2016Laresgoiti U, Nikolić MZ, Rao C, Brady JL, Richardson RV, Batchen EJ, Chapman KE, Rawlins EL.BD, 550609), LAMP3 (rat, 1:100, Dendritics, DDX0192, clone 1006F7.05), LIF (goat, 1:100, R&D Systems, AB-449-NA), LPCAT1 (rabbit, 1:500, Proteintech), PDPN (hamster, 1:1000, DSHB, 8.1.1), RFP (rabbit, 1:250, Rockland,

(13) Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodentsThe Journal of clinical investigationFebruary 1, 2010Kanazawa H, Ieda M, Kimura K, Arai T, Kawaguchi-Manabe H, Matsuhashi T, Endo J, Sano M, Kawakami T, Kimura T, et al.hearts in ice-cold buffer as described (45). Immunodetection was performed with an anti-LIF antibody (AB-449-NA; R&D Systems). After transfer to nitrocellulose membranes, LIF protein was visualized by chemiluminescence detection

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LIF Antibody

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LIF Antibody

LIF Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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LIF Antibody from R&D Systems, a Bio-Techne Brand

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