Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb 2865S from Cell Signaling Technology

Product Specs
ItemPhospho-c-Abl (Tyr412) (247C7) Rabbit mAb
CompanyCell Signaling Technology
Price $397.00 Inquire
Catalog Number2865S
Quantity100 µl
ApplicationsW
ReactivityH
TargetAbl1 (Tyr393) phosphate
IsotypeIgG
ModificationsAbl1 (Tyr393) phosphate
HostRabbit
Clone247C7
Molecular Weight135 (c-Abl); 210 (Bcr-Abl)
NCBI Gene AliasesABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
ClonalityMonoclonal
NCBI Full Gene NameABL proto-oncogene 1, non-receptor tyrosine kinase
Research AreaMAP Kinase Signaling

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosisbioRxivJune 16, 2025Manuel L. Merz, Veronika M. Shoba, Rajaiah Pergu, Zachary C. Severance, Dhanushka N. P. Munkanatta Godage, Arghya Deb, Hui Si Kwok, Prashant Singh, Sameek Singh, Jonathan B. Allen, et al.antibodies used for detecting the autophosphorylation of BCR-ABL, including pY393 (Cell Signaling, #2865), pY226 (Cell Signaling, #2861), pY70 (Cell Signaling, #3098), and cABL (Santa Cruz Biotechnology, #SC-23),

(2) Potential compensatory mechanisms preserving cardiac function in myotubular myopathyCellular and Molecular Life SciencesDecember 3, 2024Alix Simon, Nadège Diedhiou, David Reiss, Marie Goret, Erwan Grandgirard, Jocelyn Laporteantibodies used were SOD2 (D9V9C) 13,194 (Cell Signaling) 1:1000, and rabbit polyclonal against DNM2 2865 1:500 previously described [31]. Secondary antibody was goat anti-rabbit (Jackson Immunoresearch) 1:10 000

(3) Targeting FLT3-TAZ signaling to suppress drug resistance in blast phase chronic myeloid leukemiaMolecular CancerNovember 6, 2023Ji Eun Shin, Soo-Hyun Kim, Mingyu Kong, Hwa-Ryeon Kim, Sungmin Yoon, Kyung-Mi Kee, Jung Ah Kim, Dong Hyeon Kim, So Yeon Park, Jae Hyung Park, et al.(Santcruz, sc-101199), YAP/TAZ (CST, 8418), LATS (CST, 3477), PARP (CST, 9532), p-BCR::ABL1 Y412 (CST, 2865), p-BCR::ABL1 Y245 (CST, 2861), p-BCR Y177 (CST, 3901), p-ERK (CST, 4377), ERK 1/2 (CST, 4695), p-S6K

(4) ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemiasBlood cancer journalMarch 23, 2023Golovine K, Abalakov G, Lian Z, Chatla S, Karami A, Chitrala KN, Madzo J, Nieborowska-Skorska M, Huang J, Skorski T.primary antibodies against ABL1 (Santa Cruz Biotechnology, sc-56887), phospho-ABL1 (Cell Signaling, 2865), AML1 (Cell Signaling, 4334), NUP98 (Santa Cruz Biotechnology, sc-101546), phospho-CHK1 (Cell Signaling,

(5) IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone lossBone researchMarch 16, 2023Kim H, Takegahara N, Choi Y.MBS9128730; MyBioSource.com), anti-Fyn (Cat.# 4023; Cell Signaling Technology) anti-phospho cAbl (Cat.# 2865; Cell Signaling Technology), anti-phospho HcK (Cat.# ab61055; Abcam), anti-HcK (Cat.# 14643; Cell Signaling Technology

(6) The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separationCell death & diseaseFebruary 9, 2023Song C, Zhang Y, Li Y, Bie J, Wang Z, Yang X, Li H, Zhu L, Zhang T, Chang Q, et al.Anti-ABL1 (Cell Signaling Technology, Cat#2862), Anti-pABL1 (Tyr412) (Cell Signaling Technology, Cat#2865), Anti-γ-tubulin (mouse: Proteintech, Cat#66320-I-IG and rabbit: Abcam, Cat#ab179503), Anti-CEP250 (mouse:

(7) Diversity of bacterium communities in saline-alkali soil in arid regions of Northwest ChinaBMC MicrobiologyDecember 1, 2022Lili Nan, Quanen Guo, Shiyu Cao, Zongbing Zhan%,Simpson,Shannon MS.CT,"61,711",3123,3229.32,3323.79,97.4,0.988,8.69 MS.SCT,"57,043",2507,2803.08,2814.55,97.7,0.987,8.17 MS.CST,"56,870",2843,3021.27,3201.71,97.4,0.987,8.37 MS.ST.,"53,843",3254,3281.32,3368.13,97.5,0.994,9.18 OS.CT,"64,521",3148,3202.21,3249.52,97.4,0.983,8.37 OS.SCT,"59,089",1994,2284.12,2417.71,98.0,0.975,7.32 OS.CST,"59,821",2880,2900.17,3023.69,97.7,0.993,8.88 OS.ST,"63,853",2978,3260.80,3377.49,97.4,0.994,9.08 BS.CT,"57,067",3086,3417.98,3434.16,97.1,0.988,8.53 AS.Mg.S,"55,360",2865,3037.54,3177.13,97.4,0.984,8.30 DS.SCT,"47,376",2353,3047.13,2927.60,97.6,0.981,7.82 DS.CST,"58,687",2853,3047.40,3117.45,97.5,0.984,8.19 DS.ST,"53,200",2268,2369.02,2430.74,98.2,0.987,8.13 s.e.m.,0.208,75.038**,103.42**,130.54**,0.004,0.005*,0.392** MiSeq

(8) Neuronal Agrin Promotes Proliferation of Primary Human Myoblasts in an Age-Dependent MannerInternational journal of molecular sciencesOctober 4, 2022Gros K, Matkovič U, Parato G, Miš K, Luin E, Bernareggi A, Sciancalepore M, Marš T, Lorenzon P, Pirkmajer S.No.,Dilution,Source,Source/Target,Dilution c-Abl,CTS #2862,1:1000,rabbit,GAR,"1:25,000" p-c-Abl (Tyr412),CST #2865,1:1000,rabbit,GAR,"1:8000–1:25,000" p-Crk-II (Tyr221),CST #3491,1:1000,rabbit,GAR,"1:12,500–1:25,000" desmin,Dako

(9) Protein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5AThe Journal of biological chemistryApril 1, 2022Miyamoto D, Takeuchi K, Chihara K, Fujieda S, Sada K.Anti-mouse IgG (H+L), F(ab')2 fragment (Alexa Fluor 488 conjugate) (catalog number: 4408; lot number: 18), and anti-phospho-c-Abl (Tyr412) (247C7) (catalog number: 2865; lot number: 3) mAb were purchased from Cell Signaling Technology. Anti-HCV NS3 protein polyclonal antibodies

(10) The quiescent fraction of chronic myeloid leukemic stem cells depends on BMPR1B, Stat3 and BMP4-niche signals to persist in patients in remissionHaematologicaJanuary 1, 2021Jeanpierre S, Arizkane K, Thongjuea S, Grockowiak E, Geistlich K, Barral L, Voeltzel T, Guillemin A, Gonin-Giraud S, Gandrillon O, et al.monoclonal-antibodies against P-ERK (#4370), ERK (#4695), P-STAT3 (#9145), STAT3 (#9139), Caspase 3 (#9662). P-ABL (#2865), P-CRKL (#3181), P-Smad1/5/8 (#13820), GAPDH (#8884) (Cell Signalling Technology), BCR-ABL (ThermoFisher,

(11) Conformational states dynamically populated by a kinase determine its functionScienceOctober 9, 2020Tao Xie, Tamjeed Saleh, Paolo Rossi, Charalampos G. KalodimosAbl phosphorylation was monitored by western blot analysis with an antibody specific to Abl pTyr412 (2865S, Cell Signaling Technology). Western blot indicated phosphorylation of Abl by Hck led to the phosphorylation

(12) c-Abl Tyrosine Kinase Is Regulated Downstream of the Cytoskeletal Protein Synemin in Head and Neck Squamous Cell Carcinoma Radioresistance and DNA RepairInternational journal of molecular sciencesOctober 1, 2020Deville SS, Delgadillo Silva LF, Vehlow A, Cordes N.irradiation. 4.3. Antibodies Antibodies against c-Abl (#2862P), c-Abl T715 (#2846S), and c-Abl Y412 (#2865S) were from Cell Signaling (Frankfurt, Germany); β-actin (#A1978) and Synemin (#S9075, for zebrafish

(13) Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 MutantsCancer CellOctober 1, 2019Christopher A. Eide et al.immunoblotted with antibodies for the BCR N-terminus (3902; Cell Signaling), phospho-ABLl (Y393 [1a numbering]; 2865; Cell Signaling), ABL1 (554148; BD Biosciences), phospho-CRKL (Tyr207) (3181S; Cell Signaling), phospho-STAT5

(14) Rho-kinase inhibition has antidepressant-like efficacy and expedites dendritic spine pruning in adolescent miceNeurobiology of DiseaseApril 1, 2019Lauren P. Shapiro, Henry W. Kietzman, Jidong Guo, Donald G. Rainnie, Shannon L. Gourley3",1:250 anti-AKT,Rabbit-monoclonal,"Cell Signaling #4691, lot 17",1:1000 anti-phospho AKT (Thr308),Rabbit-monoclonal,"Cell Signaling #2865, lot 13",1:500 anti-GAPDH,Mouse-monoclonal,"Sigma #G8795, lot 044m4808v",1:5000 Antibodies used

(15) Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting AvenCellular & molecular biology lettersJanuary 1, 2019Zhang L, Jia X.anti-Bax (1: 500, #2774, Cell signaling), anti-Bcl-2 (1: 500, #2876, Proteintech), anti-Aven (1: 1000, #2865, Cell signaling) or anti-GAPDH (1: 500000, 10,494–1-AP, Proteintech). Next day, the membranes were incubated

(16) A dynamic N⁶-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitorsCell researchNovember 1, 2018Yan F, Al-Kali A, Zhang Z, Liu J, Pang J, Zhao N, He C, Litzow MR, Liu S.(1:500, Cell Signaling #3464), anti-BCR (1:500, Cell Signaling #3902), anti-p-ABL (1:500, Cell Signaling #2865), anti-β-Actin (1:1000, Santa Cruz #sc-47778), anti-MERTK (1:1000, Santa Cruz #sc-365499), anti-FTO

(17) Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Regulates Retinal Axonal Projections by Inhibiting Eph and Abl Kinases in MiceThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 26, 2018Yu Y, Shintani T, Takeuchi Y, Shirasawa T, Noda M.and rabbit anti-phosphorylated c-Abl (Tyr-412) antibody (rabbit monoclonal; 1:1000 dilution; catalog #2865S, Cell Signaling Technology; RRID:AB_331381). Peroxidase-conjugated secondary antibodies were from GE

(18) Role and regulation of Abelson tyrosine kinase in Crk-associated substrate/profilin-1 interaction and airway smooth muscle contractionRespiratory researchJanuary 5, 2018Wang Y, Rezey AC, Wang R, Tang DD.#sc-23, L/N k0111 and #sc-56,887, L/N h1712), phospho-c-Abl (Y412) antibody (1:1000, Cell Signaling, #2865 s, L/N 3; Santa Cruz, #sc-101,626, L/N k0911), phospho-MLC (S19) antibody (1:1000, Santa Cruz, #sc-19,849-4),

(19) A Split-Abl Kinase for Direct Activation in CellsCell Chemical BiologyOctober 19, 2017Juan E. Diaz, Charles W. Morgan, Catherine E. Minogue, Alexander S. Hebert, Joshua J. Coon, James A. WellsSrc,Thermo-Scientific,MA5-15120 Anti-Phospho-Src Y416,Cell Signaling Technology,#2113 Anti-Phospho-Abl Y412,Cell Signaling Technology,#2865 Phospho-Y-100 & Phospho-Y-1000,Cell Signaling Technology,#9411 & #8954 Anti-GAPDH,Cell Signaling Technology,#14C10 Anti-Myc

(20) The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylationScientific reportsSeptember 18, 2017Wang Y, Hall RA, Lee M, Kamgar-Parsi A, Bi X, Baudry M.phosphotyrosine (05–321, EMD Millipore), Phospho-c-Abl Tyr245 (1:800, 2861, CST), Phospho-c-Abl Tyr412 (1:800, 2865, CST) and actin (1:10000, A2228, Sigma-Aldrich). The secondary antibodies used for WB were IRDye 680RD

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Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb

Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-c-Abl (Tyr412) (247C7) Rabbit mAb from Cell Signaling Technology

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