TERT Antibody (2D8)

Product Specs
ItemTERT Antibody (2D8) - BSA Free
CompanyNovus Biologicals, a Bio-Techne Brand
Price $429.00Supplier Page View Company Product Page
Catalog NumberNB100-297
NCBI Gene AliasesTP2, DKCB4, hTRT, PFBMFT1, CMM9, EST2, hEST2, TRT, DKCA2, TCS1
ImmunogenFull-length recombinant human Telomerase reverse transcriptase from insect cells. [UniProt# O14746]
Quantity0.1 ml (also 0.025 ml)
Conjugate/TagUnconjugated
FormatAscites
IsotypeIgM
HostMouse
ApplicationsIF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Knockdown Validated,Immunocytochemistry/ Immunofluorescence
ReactivityHuman
TargetTERT
Clone2D8
ClonalityMonoclonal
NCBI Full Gene Nametelomerase reverse transcriptase
PurityUnpurified
Molecular Weight127 kDa
Research AreaAutophagy, Cancer, Cellular Markers, Chromatin Research, DNA Repair, DNA replication Transcription Translation and Splicing, Stem Cell Markers
Antibody TypePrimary Antibodies
StorageAliquot and store at -20C or -80C. Avoid freeze-thaw cycles

Specifications/Features

Available conjugates: Unconjugated

Questions and Answers

Can this TERT antibody be used for studying telomerase activity in human cancer cells?

Yes, the TERT antibody (2D8) has been utilized in various applications, including Western Blotting and Immunohistochemistry, which are commonly employed to study telomerase activity in human cancer cells. Its reactivity with human TERT makes it suitable for such investigations.

What applications has this antibody been shown to work in?

The TERT antibody has been shown to work in several applications, including Western Blotting, Flow Cytometry, Immunocytochemistry, Immunofluorescence, and both paraffin-embedded and frozen tissue sections in Immunohistochemistry.

Is this antibody suitable for use in stem cell research?

Yes, the TERT antibody is relevant for stem cell research as it is associated with cellular markers and telomerase activity, which are critical in the study of stem cell biology and maintenance.

What is the host species for this TERT antibody, and how does that affect its use?

The TERT antibody is derived from a mouse host species. This is important as it may influence the choice of secondary antibodies used in experiments, as well as the compatibility with various assay systems that may require specific host species for optimal performance.

Novus Biologicals, a Bio-Techne Brand

United States: 10771 E Easter Ave

Centennial, Colorado 80112

United States

Phone:
303-730-1950
888-506-6887

Email: novus@novusbio.com

Company Profile

Website: https://www.novusbio.com

(1) Telomerase activation as a repair response to radiation-induced DNA damage in Y79 retinoblastoma cellsCancer lettersOctober 28, 2013Akiyama M, Ozaki K, Kawano T, Yamada O, Kawauchi K, Ida H, Yamada H.

(2) EGFR overexpression induces activation of telomerase via PI3K/AKT-mediated phosphorylation and transcriptional regulation through Hif1-alpha in a cellular model of oral-esophageal carcinogenesisCancer scienceFebruary 1, 2011Heeg S, Hirt N, Queisser A, Schmieg H, Thaler M, Kunert H, Quante M, Goessel G, von Werder A, Harder J, et al.

(3) Localization of telomerase hTERT protein in frozen sections of basal cell carcinomas (BCC) and tumor margin tissuesInternational journal of oncologyDecember 1, 2009Fabricius EM, Kruse-Boitschenko U, Khoury R, Wildner GP, Raguse JD, Klein M, Hoffmeister B.

(4) Immunohistochemical determination of the appropriate anti-hTERT antibodies for in situ detection of telomerase activity in frozen sections of head and neck squamous cell carcinomas and tumor margin tissuesInternational journal of oncologyMay 1, 2009Fabricius EM, Kruse-Boitschenko U, Khoury R, Wildner GP, Raguse JD, Klein M.

(5) Quantitation of HER2 and telomerase biomarkers in solid tumors with IgY antibodies and nanocrystal detectionInternational journal of cancerMay 15, 2008Xiao Y, Gao X, Gannot G, Emmert-Buck MR, Srivastava S, Wagner PD, Amos MD, Barker PE.

(6) Antigenic profiling of glioma cells to generate allogeneic vaccines or dendritic cell-based therapeuticsClinical cancer research : an official journal of the American Association for Cancer ResearchJanuary 15, 2007Zhang JG, Eguchi J, Kruse CA, Gomez GG, Fakhrai H, Schroter S, Ma W, Hoa N, Minev B, Delgado C, et al.

(7) Generation and characterization of iBREC: novel hTERT-immortalized bovine retinal endothelial cellsInternational journal of molecular medicineJuly 1, 2005Deissler H, Deissler H, Lang GK, Lang GE.

(8) The telomerase reverse transcriptase regulates chromatin state and DNA damage responsesProceedings of the National Academy of Sciences of the United States of AmericaJune 7, 2005Masutomi K, Possemato R, Wong JM, Currier JL, Tothova Z, Manola JB, Ganesan S, Lansdorp PM, Collins K, Hahn WC.

(9) Evolving views of telomerase and cancerTrends in cell biologyJune 1, 2003Blasco MA, Hahn WC.

Be the First to Write a Review!