Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb 4407L from Cell Signaling Technology

Product Specs
ItemPhospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb
CompanyCell Signaling Technology
Price $947.00 Inquire
Catalog Number4407L
Quantity300 µl
ApplicationsW, W-F, IP, IHC-P
ReactivityH, M, R
TargetEGFR (Tyr1197) phosphate
ModificationsEGFR (Tyr1197) phosphate
HostRabbit
NCBI Gene AliasesERBB, ERBB1, ERRP, HER1, NISBD2, PIG61, mENA
ClonalityMonoclonal
NCBI Full Gene Nameepidermal growth factor receptor
Research AreaRTK
IsotypeIgG
Clone53A5
Molecular Weight175

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) CLPTM1L modulates membrane lipid rafts to promote tumor EGFR signalingLife MetabolismMay 20, 2026Dejian Pang, Xuan Yang, Xinyao Li, Zixuan Xue, Xincan Hou, Kemu Xiao, Yun Yang, Guanlin Wang, Tong-Jin Zhao, Junfeng BiCLPTM1L (HPA014791, Sigma), EGFR (4267, Cell Signaling), pEGFR-Y1068 (3777, Cell Signaling), pEGFR-Y1173 (4407, Cell Signaling), pAKT-S473 (4060, Cell Signaling), pS6-S235/236 (4858, Cell Signaling), pERK1/2 (4370,

(2) A Tri-specific EGFR/cMet/VEGF Antibody Demonstrates Potent Multi-Mechanistic Activity in Preclinical Triple-Negative Breast Cancer ModelsJournal of Biological ChemistryApril 30, 2026Pu Pu, Ying Jin, Songling Zhang, Yuqiang Xu, Peng Chen, Fulai Fulai, Ping Ping, Hao Jiang, Sheng Huang, Limin Chen, et al.overnight at 4 °C with the following primary antibodies (1:500 diluted): α-phospho-EGFR Y1173 (CST, 4407S), α-EGFR (CST, 2085S), α-phospho-cMet Y1349 (CST, 3121S), α-cMet (CST, 4560S), α-β-Actin (CST, 8457S). Statistical

(3) Quantitative HER2 tissue and plasma profiling predicts the activity of trastuzumab deruxtecan for breast cancernpj Precision OncologyMarch 13, 2026Paolo Tarantino, Se-Eun Kim, Melissa E. Hughes, Ross J. Kusmick, Kalie Smith, Fara Brasó-Maristany, Nay Nwe Nyein Chan, Laia Paré Brunet, Laura Alder, Diana Garcia-Cortes, et al.antibodies (EGFR T654, Abcam ab75986; EGFR Y1068, Cell Signaling Technology (CST) 3777; EGFR Y1173, CST 4407; HER2, Thermo Fisher Scientific MA5-14509; HER2 Y1248, Abcam ab201013; HER3 Y1289, CST 4791; SLFN11,

(4) An MIEN1-based hexamer peptide (LA3IK) inhibits EGF-driven oncogenic signaling in prostate cancer by disrupting EGFR-ERBB2 heterodimerizationScientific reportsMarch 5, 2026Tripathi AK, Ahamad N, Tyagi A, Quainoo B, Smith AW, Singh P, Sabnis N, Vishwanatha JK.this study included phospho-EGFR Y1068 Rabbit mAb (Cat# 3777), phospho-EGFR Y1173 Rabbit mAb (Cat# 4407), phospho-EGFR Y992 Rabbit mAb, (Cat# 2235), and total EGFR Rabbit mAb(Cat# 4267), all obtained from

(5) Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell disseminationbioRxivFebruary 8, 2026Pietro Berico, Cody Dunton, Luay Almassalha, Amanda Flores Flores-Yanke, Karla I. Medina, Nicolas Acosta, Tara Muijlwijk, Catherine Do, Soobeom Lee, Sharon N Edmiston, et al.#HPA003259), TCF4 (Abcam, #ab223073), S100B (Abcam, #ab115803), p-EGFR (Cell Signaling Technology, #4407), AXL (Cell Signaling Technology, #8661), and SOX10 (Sigma-Aldrich, #383R-15). After antibody staining,

(6) Netrin-1 inhibits the attachment and internalization of Hepatitis B virus for hepatocyte infectionPLoS PathogDecember 17, 2025Ying Wang, Kazuhisa Murai, Atsuya Ishida, Narumi Kawasaki, Kazuyuki Kuroki, Ying-Yi Li, Yuga Sato, Yutaro Miura, Kureha Takara, Lianghao Kong, et al.Japan), EGFR (4267; CST), p-EGFR(Tyr845) (2231; CST), p-EGFR(Tyr1068) (2234; CST), p-EGFR(Tyr1173) (4407; CST), p-Tyr(PY99) (sc-7020; Santa Cruz Biotechnology, Dallas, TX), Akt (4685; CST), p-AKT (9271; CST),

(7) Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer MetastasisCancer researchDecember 1, 2025Liu S, Hsu EC, Aslan M, Garcia-Marques F, Shen M, Hartono AB, Solano F, Le K, Hwang H, Lee CS, et al.RRID:AB_1130910); anti-phospho-EGF Receptor (Tyr1173) (53A5), 1:1000, Cell Signaling Technology Cat# 4407, RRID:AB_331795; anti-E-Cadherin (24E10), 1:1000, Cell Signaling Technology Cat# 3195, RRID:AB_2291471;

(8) Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancersCell Reports MedicineAugust 19, 2025Madelaine S. Theardy, Mitsunobu Takeda, Alexey Sorokin, Shuaitong Chen, Zecheng Yang, Xiaofei Wang, Preeti Kanikarla, Oluwadara Coker, Phuoc Nguyen, Yongkun Wei, et al.Anti-EGFR (Cell Signaling Technology, 4267, 1:1000 for WB); Anti-phospho-EGFR (Cell Signaling Technology, 4407, 1:1000 for WB); Anti-MET (Cell Signaling Technology, 3135, 1:1000 for WB); Anti-phospho-MET (Cell Signaling

(9) Mechanistic modeling identifies emergent properties of tandem SH2 domain interactionsbioRxivMay 16, 2025Reagan Portelance, Anqi Wu, Alekhya Kandoor, Kristen M. Naegledilution; EGFR pY1148/EGFR pY1172 Rabbit CST 4404 at 1:1000 dilution; EGFR pY1173/EGFR pY 1197 Rabbit CST 4407 at 1:1000 dilution. We used the following secondary antibodies from LI-COR Biosciences (at 1:10,000

(10) BRAF(V600E)-Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor SignalingbioRxiv : the preprint server for biologyMay 9, 2025Dacheux MA, Wu MJ, Scherzer MT, Nillson M, Murphy B, Schuman S, Ju Z, Bivona T, Lito P, Gumbleton M, et al.Catalog t# 4696S; RRID: AB_10694988). Anti-pY1068/pY1173-EGFR (1H12/2236S); Cell Signaling (Catalog# 53A5/4407S; RRID: AB_331795). Anti-total EGFR (D38B1); Cell Signaling (Catalog# 4267S; RRID: AB_2246311). Anti-pS473-AKT

(11) Thermal cycling‑hyperthermia sensitizes non‑small cell lung cancer A549 cells to EGFR tyrosine kinase inhibitor erlotinibOncology reportsMay 1, 2025Lin GB, Chen WT, Kuo YY, Liu HH, Chen YM, Leu SJ, Chao CY.antibodies at 4°C overnight. The specific primary antibodies against phosphorylated EGFR (p-EGFR; cat. no. 4407; Cell Signaling Technology, Inc.), poly ADP-ribose polymerase (PARP; cat. no. 9542; Cell Signaling Technology,

(12) Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistanceNat CommunApril 25, 2025Zhilan Zhou, Yichang Liu, Ya Wang, Hang Jiang, Tingting Chen, Yingdi Zhu, Ting Fu, Juan LiChina) and anti-GAPDH (60001-1-Ig, Proteintech, China) antibody, anti-phospho-EGFR (Y1173) (1:1000, #4407, CST, USA), anti-phospho-EGFR (Y1148) (1:1000, #4404, CST, USA), anti-phospho-EGFR (Y1086) (1:1000,

(13) EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancerMol CancerMarch 22, 2025Jiefu Zhou, Min He, Qiong Zhao, Enxian Shi, Hairong Wang, Vaidehi Ponkshe, Jiahang Song, Zhengquan Wu, Dongmei Ji, Gisela Kranz, et al.of total and phosphorylated EGFR and ERK1/2 was done according to [10] with phospho-EGFR (Tyr1173) (#4407), EGFR (#2232), phospho-ERK1/2 (#4370) and ERK1/2 (#4695), all from Cell Signaling Technology (Leiden,

(14) Reciprocal regulation of MMP-28 and EGFR is required for sustaining proliferative signaling in PDACJournal of experimental & clinical cancer research : CRFebruary 24, 2025Hong Z, Huang X, Xia L, Liang T, Bai X.antibody (4267, CST, 1:1000 for immunoblotting, 1:100 for IP), Phospho-EGF Receptor (Tyr1173) antibody (4407, CST, 1:1000 for immunoblotting, 1:100 for mIHC), Phospho-EGF Receptor (Tyr1068) antibody (3777, CST,

(15) Cell migration signaling through the EGFR-VAV2-Rac1 pathway is sustained in endosomesJournal of Cell ScienceJanuary 15, 2025Itziar Pinilla-Macua, Sachin Surve, Alexander SorkinAntibodies against GAPDH (#2118), EGFR (#4267), Akt (#9272), EGFR pTyr992 (#2235), EGFR pTyr1173 (#4407) and α-actinin (#6487) were from Cell Signaling Technology. Antibodies against VAV2 (sc-271442) and

(16) Pre-Clinical Rationale for Amcenestrant Combinations in HER2+/ER+ Breast CancerInt J Mol SciJanuary 8, 2025Amira F. Mahdi, Niall Ashfield, John Crown, Denis M. Collinsused were HER2 (Calbiochem #OP15), p-HER2 Y1221/1222 (CST #2249), EGFR (CST #2232), p-EGFR Y1173 (CST #4407), ERK1/2 (CST #4695), p-ERK1/2 T202/Y204 (CST #9101), Akt (CST #9272), p-Akt S473 (CST #9271), ERα (Invitrogen,

(17) Tumor Cell Spatial Organization Directs EGFR/RAS/RAF Pathway Primary Therapy Resistance through YAP SignalingbioRxivDecember 24, 2024Rachel Nakagawa, Andrew Beardsley, Sophia Durney, Mary-Kate Hayward, Vishvak Subramanyam, Nathaniel P. Meyer, Harrison Wismer, Hani Goodarzi, Valerie M Weaver, Daniel Van de Mark, et al.concentrations. Antibodies for Western blots: β-actin (Santa Cruz #sc-47778), EGFR (CST #2232), pEGFR (CST #4407), YAP (CST #4912), YAP (CST #D8H1X), p-YAP (CST #13008), vinculin (CST #13901), Histone H3 (CST #9715).

(18) Pleiotropic tumor suppressive functions of PTEN missense mutations during gliomagenesisiScienceDecember 20, 2024Hyun Jung Jun, Joao A. Paulo, Victoria A. Appleman, Tomer M. Yaron-Barir, Jared L. Johnson, Alan T. Yeo, Vaughn A. Rogers, Shan Kuang, Hemant Varma, Steven P. Gygi, et al.,Cell Signaling Technology,2220 anti-EGFR-tyr1148,Cell Signaling Technology,4404 anti-EGFR-tyr1173,Cell Signaling Technology,4407 anti-EGFR,Cell Signaling Technology,2232 anti-b-actin,Cell Signaling Technology,3700 anti-pan-cadherin,Cell Signaling Technology

(19) Targeting ERBB3 and AKT to overcome adaptive resistance in EML4-ALK-driven non-small cell lung cancerCell Death & DiseaseDecember 18, 2024Josephina Sampson, Hyun-min Ju, Nan Zhang, Sharon Yeoh, Jene Choi, Richard Bayliss-ALK (31F12) mouse mAb,CST,3921,1:1000 Anti-phospho-ALK (Y1604) rabbit mAb,CST,3341,1:1000 Anti-phospho-EGFR (Y1173) rabbit mAb,CST,4407,1:1000 Anti-EGFR (D38B1) rabbit mAb,CST,4267,1:2000 Anti-phospho-ERBB3 (Y1289) rabbit mAb,CST,4791,1:1000 Anti-ERBB3

(20) Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapyGastric CancerNovember 1, 2024Ozen Leylek, Megan E. Honeywell, Michael J. Lee, Michael T. Hemann, Gulnihal Ozcanat 4 °C overnight with 1:1000 diluted EGFR (Cell signaling #2232), p-EGFR (Tyr1173) (Cell signaling #4407), mTOR (Cell signaling #2972), p-mTOR (Ser2448) (Cell signaling #2971), Met (25H2) (Cell signaling #3127),

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Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb

Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb from Cell Signaling Technology

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