PDE6A Antibody PA1-720 from Thermo Fisher Scientific

Product Specs
ItemPDE6A Antibody
CompanyThermo Fisher Scientific
Price Supplier Page
Catalog NumberPA1-720
ApplicationsImmunocytochemistry, Western Blot
ReactivityBovine, Human, Ovine
ClonalityPolyclonal
HostRabbit
FormatPBS with 1mg/mL BSA and 0.05% sodium azide
Quantity100 µg
Conjugate/TagUnconjugated
TargetPDE6A
Concentration1 mg/mL
ImmunogenSynthetic Peptide: M(1) G E V T A E E V E K F L D S N(16) C
IsotypeIgG
Storage Temperature-20° C, Avoid Freeze/Thaw Cycles
PurityAntigen affinity chromatography
Antibody TypePrimary
NCBI Gene AliasesCGPR-A, RP43, PDEA
Storage-20°C, Avoid Freeze/Thaw Cycles
NCBI Full Gene Namephosphodiesterase 6A

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Thermo Fisher Scientific

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Waltham, MA 02451

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Fax: 800-331-2286

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Website: www.thermofisher.com

(1) AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosisNeural Regeneration ResearchAugust 1, 2025Ruiqi Qiu, Mingzhu Yang, Xiuxiu Jin, Jingyang Liu, Weiping Wang, Xiaoli Zhang, Jinfeng Han, Bo LeiCat# PA1-722, RRID: AB_2161443), rabbit anti-PDE6A antibody (1:500, Thermo Fisher Scientific, Cat# PA1-720, RRID: AB_2268019), rabbit anti-Rom1 antibody (1:1000, Cusabio, Wuhan, China, Cat# CSB-PA344843ESR2HU,

(2) Proteomics identifies multiple retinitis pigmentosa associated proteins involved in retinal degeneration in a mouse model bearing a Pde6b mutationScientific reportsSeptember 27, 2024Yang M, Qiu R, Jin X, Yao S, Wang W, Liu J, Liu G, Han J, Lei B.by an overnight incubation with antibodies against Pde6b (PA1-722, Thermo Fisher Scientific), Pde6a (PA1-720, Thermo Fisher Scientific), Tulp1 (18971-1-AP, Proteintech, Chicago, USA), Prph2 (18109-1-AP, Proteintech),

(3) Regulation of rod photoreceptor function by farnesylated G-protein γ-subunitsPloS oneJanuary 1, 2022Kolesnikov AV, Lobysheva E, Gnana-Prakasam JP, Kefalov VJ, Kisselev OG.CA). Mouse FLAG M2 F1804 were from Sigma-Aldrich. Rabbit HA TA150084 were from Origene. Rabbit PDE6A PA1-720, PDE6G PA1-723 and beta Actin PA1-16889 and secondary HRP antibodies were from Invitrogen. Rabbit antibodies

(4) Essential role of the chaperonin CCT in rod outer segment biogenesisInvestigative ophthalmology & visual scienceMay 22, 2014Sinha S, Belcastro M, Datta P, Seo S, Sokolov M.(sc-57432; Santa Cruz Biotechnology), b-tubulin (T0198; Sigma), GFP (A11122; Invitrogen), and PDE 6 a (PA1-720; Thermo Scientific, Rockford, IL, USA). Antibody against phosducin was previously described.33 Antibodies against

(5) Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epitheliumThe Journal of biological chemistryJuly 13, 2012Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD.

(6) Effect of the ILE86TER mutation in the γ subunit of cGMP phosphodiesterase (PDE6) on rod photoreceptor signalingCellular signallingJanuary 1, 2012Tsang SH, Woodruff ML, Lin CS, Jacobson BD, Naumann MC, Hsu CW, Davis RJ, Cilluffo MC, Chen J, Fain GL.dilution of a polyclonal antibody directed against amino acid residues 2–16. Other antibodies were: PDE6α(PA1-720, 1:2,000, Thermo Scientific), RGS9 (from M.I. Simon, 1:5,000), Gαt (K60006R, 1:5,000, Meridian Life

(7) Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivoCellular signallingOctober 1, 2011Tsang SH, Woodruff ML, Hsu CW, Naumann MC, Cilluffo M, Tosi J, Lin CS.Los Angeles, CA, USA) The PDE6α and β subunits were detected by incubation with a polyclonal antisera PA1-720 and PA1-722, respectively (Affinity Bioreagents, Thermo) Primary antibodies to other phototransduction

(8) RD3, the protein associated with Leber congenital amaurosis type 12, is required for guanylate cyclase trafficking in photoreceptor cellsProceedings of the National Academy of SciencesDecember 7, 2010Seifollah Azadi, Laurie L. Molday, Robert S. Molday

(9) In vitro interaction of tubulin with the photoreceptor cGMP phosphodiesterase gamma-subunitNeuroscience lettersOctober 4, 2010Chu UB, Song J, Mavlyutov TA, Guo LW.

(10) Replacing the rod with the cone transducin subunit decreases sensitivity and accelerates response decayThe Journal of physiologySeptember 1, 2010Chen CK, Woodruff ML, Chen FS, Shim H, Cilluffo MC, Fain GL.

(11) High levels of retinal membrane docosahexaenoic acid increase susceptibility to stress-induced degenerationJournal of lipid researchMay 1, 2009Tanito M, Brush RS, Elliott MH, Wicker LD, Henry KR, Anderson RE.

(12) Phototransduction in a transgenic mouse model of Nougaret night blindnessThe Journal of neuroscience : the official journal of the Society for NeuroscienceJune 21, 2006Moussaif M, Rubin WW, Kerov V, Reh R, Chen D, Lem J, Chen CK, Hurley JB, Burns ME, Artemyev NO.Princeton, NJ); 1D4 monoclonal anti-rod opsin (National Cell Culture Center, Minneapolis, MN); anti-PDE6␣ (PA1-720) and anti-PDE6␤ (PA1-722) (Affinity Bioreagents, Golden, CO); or antiRGS9. Anti-peptide RGS9-469-484

(13) The inhibitory gamma subunit of the rod cGMP phosphodiesterase binds the catalytic subunits in an extended linear structureThe Journal of biological chemistryJune 2, 2006Guo LW, Muradov H, Hajipour AR, Sievert MK, Artemyev NO, Ruoho AE.

(14) GAP-independent termination of photoreceptor light response by excess gamma subunit of the cGMP-phosphodiesteraseThe Journal of neuroscience : the official journal of the Society for NeuroscienceApril 26, 2006Tsang SH, Woodruff ML, Chen CK, Yamashita CY, Cilluffo MC, Rao AL, Farber DB, Fain GL.Texas Southwestern Medical Center at Dallas, Dallas, TX), GC-F (A670, 1:5000; from D. Garbers), PDE6␣ (PA1–720, 1:500; Affinity Bioreagents), RK (MA1–721, 1:5000; Affinity Bioreagents), arrestin (Marr, 1:20,000),

(15) Transducin activation state controls its light-dependent translocation in rod photoreceptorsThe Journal of biological chemistryDecember 9, 2005Kerov V, Chen D, Moussaif M, Chen YJ, Chen CK, Artemyev NO.

(16) Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitationMolecular reproduction and developmentAugust 1, 2005Baxendale RW, Fraser LR.

(17) Asymmetric interaction between rod cyclic GMP phosphodiesterase gamma subunits and alphabeta subunitsThe Journal of biological chemistryApril 1, 2005Guo LW, Grant JE, Hajipour AR, Muradov H, Arbabian M, Artemyev NO, Ruoho AE.

(18) Enhancement of phototransduction g protein-effector interactions by phosphoinositidesThe Journal of biological chemistryMarch 5, 2004He F, Mao M, Wensel TG.

(19) Identification of the gamma subunit-interacting residues on photoreceptor cGMP phosphodiesterase, PDE6alpha 'The Journal of biological chemistryDecember 29, 2000Granovsky AE, Artemyev NO.

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PDE6A Antibody from Thermo Fisher Scientific

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PDE6A Antibody from Thermo Fisher Scientific

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