SRRM2 Antibody PA5-66827 from Thermo Fisher Scientific

Product Specs
ItemSRRM2 Antibody
CompanyThermo Fisher Scientific
Price Supplier Page
Catalog NumberPA5-66827
StorageStore at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles
Antibody TypePrimary
PurityAntigen affinity chromatography
Concentration0.10 mg/mL
ReactivityHuman (Hu)
ClonalityPolyclonal
NCBI Gene Aliases300-KD, CWF21, Cwc21, HSPC075, SRL300, SRm300
NCBI Full Gene Nameserine/arginine repetitive matrix 2
ApplicationsImmunocytochemistry (ICC)
ImmunogenRecombinant Human SRRM2. Recombinant protein control fragment (Product #RP-105385)
HostRabbit
IsotypeIgG
TargetSRRM2
FormatPBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Conjugate/TagUnconjugated
Quantity100 µL

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Thermo Fisher Scientific

81 Wyman Street

Waltham, MA 02451

United States

Phone: 800-678-5599
Fax: 800-331-2286

Company Profile

Website: www.thermofisher.com

(1) HIV-1 uncoating location dictates sites of integrationNature CommunicationsApril 9, 2026Ryan C. Burdick, Sean C. Patro, Ellie Bare, Rokeya Siddiqui, Krista A. Delviks-Frankenberry, Olga A. Nikolaitchik, Stephen H. Hughes, Xiaolin Wu, Wei-Shau Hu, Vinay K. Pathakdetermined by immunofluorescence staining of SRRM2, another NS marker, using rabbit anti-SRRM2 antibody (PA5-66827; Invitrogen) followed by donkey anti-rabbit antibody labeled with Alexa Fluor 488 (A21206; Invitrogen). Generation

(2) Nuclear speckles enable processing of RNA from GC-rich isochoresCellApril 2, 2026Michał Małszycki, Lisa Martina, İbrahim Avşar Ilık, Daniela Salgado Salgado Figueroa, Nirmalya Dasgupta, Menşura Feray Çoşar, Keun-Tae Kim, Gil Carraco, Beatrix Fauler, David Meierhofer, et al.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies Rabbit polyclonal anti-SRRM2,Thermo Fisher Scientific,Cat# PA5-66827 Rabbit polyclonal anti-SON,Sigma-Aldrich,Cat# HPA023535 Mouse monoclonal anti-SON,Santa Cruz,Cat#

(3) Nuclear tau aggregates inhibit RNA export and form by secondary seeding from cytosolic tau aggregatesbioRxivFebruary 21, 2026Carolyn J. Decker, Kathleen McCann, Evan Lester, James Pratt, Meaghan Van Alstyne, Yuchen Wang, Roy Parkerthen fixed and permeabilized and immunofluorescence using rabbit anti-SRRM2 antibody (Thermo Fisher PA5–66827) 1:400 or rabbit anti-pinin antibody (ProteinTech 18266–1-AP) 1:200 and anti-rabbit IgG AlexaFluor647

(4) Cellular quiescence uncouples the proteome from the transcriptome in neural stem cellsThe EMBO JournalFebruary 5, 2026Alice Rossi, Antoine Coum, Manon Madelenat, Lachlan Harris, Stephanie Strohbuecker, Andrea Chai, Hania Fiaz, Rita Chaouni, Peter Faull, Neve Costello Heaven, et al.diluted 1/400); mouse anti-phosphoSR (Sigma MABE50, diluted 1/500); rabbit anti-Srrm2 (ThermoFisher PA5-66827, diluted 1/1000). Antibodies used for fluorescence-activated cell sorting of hematopoietic cells were:

(5) RNA splicing is required for timely completion of abscission and is modulated by the abscission checkpointbioRxivJanuary 16, 2026Genevieve C. Couldwell, Jessica N. Vincent-Mueller, Douglas R. Mackay, Christopher C. Jensen, Chris J. Stubben, Li Li, Aik Choon Tan, Wesley I. Sundquist, Katharine S. Ullmanmonoclonal),Cell Signaling Technology,14434,1:500 Antibody,anti-SRRM2 (rabbit polyclonal),ThermoFisher,PA5-66827,"1:5,000" Antibody,anti-SRSF7 (rabbit polyclonal),ThermoFisher,PA5-60537,1:500 Chemical Compound,Thymidine,CalBiochem,CAS

(6) DNA methylation insulates genic regions from CTCF loops near nuclear specklesElifeSeptember 3, 2025Shelby A Roseman, Allison P Siegenfeld, Ceejay Lee, Nicholas Z Lue, Amanda L Waterbury, Brian B Liau(1:2000, Cell Signaling Technology D31H2); SON (1:1000, Abcam ab121759); SRRM2 (1:1000, Thermo Fisher PA5-66827); GAPDH (1:2000, Santa Cruz Biotechnology sc-47724); Vinculin (1:2000, Cell Signaling Technology 13901S). Immunofluorescence Immunofluorescence

(7) DNA methylation insulates genic regions from CTCF loops near nuclear speckleseLifeSeptember 3, 2025Shelby A Roseman, Allison P Siegenfeld, Ceejay Lee, Nicholas Z Lue, Amanda L Waterbury, Brian B Liau(1:2000, Cell Signaling Technology D31H2); SON (1:1000, Abcam ab121759); SRRM2 (1:1000, Thermo Fisher PA5-66827); GAPDH (1:2000, Santa Cruz Biotechnology sc-47724); Vinculin (1:2000, Cell Signaling Technology 13901S). Immunofluorescence Immunofluorescence

(8) Rainbow Nucleus Charts Dynamic Interactome of Membrane-less OrganellesBIORXIVMay 15, 2025Songtao Ye, Nadav Benhamou Goldfajn, Choon Leng So, Takanari Inoue, Danfeng CaiAnti-PML Protein antibody [EPR16792] (ab179466, abcam, 1:5000 dilution) and SRRM2 Polyclonal Antibody (PA5–66827, ThermoFisher, 1:2000 dilution), anti-β-actin antibodies (A1978, Millipore Sigma, 1:10000 dilution),

(9) Profiling transcriptome composition and dynamics within nuclear compartments using SLAM-RT&TagMolecular CellApril 3, 2025Nadiya Khyzha, Kami Ahmad, Steven Henikoff(Abcam ab11826), rabbit anti-SON (Novus Biologicals NBP1–88706) and rabbit anti-SRRM2 (Thermo Scientific PA5–66827). The following secondary antibodies were used for RT&Tag and SLAM-RT&Tag: Guinea Pig anti-Rabbit (Antibodies Online

(10) RBBP6 anchors pre-mRNA 3′ end processing to nuclear speckles for efficient gene expressionMolecular CellFebruary 6, 2025Yoseop Yoon, Elodie Bournique, Lindsey V. Soles, Hong Yin, Hsu-Feng Chu, Christopher Yin, Yinyin Zhuang, Xiangyang Liu, Liang Liu, Joshua Jeong, et al.F1804–200UG), anti-RBBP6 (Bethyl, A304–975A), anti-SC-35* (SRRM2) (abcam, ab11826), anti-SRRM2 (Invitrogen, PA5–66827), anti-SON (Santa Cruz, sc-398508), anti-CPSF30 (bethyl, A301–585A), anti-CPSF160 (bethyl, A301–580A),

(11) The Nuclear Speckles Protein SRRM2 Is Exposed on the Surface of Cancer CellsCellsSeptember 17, 2024Kellner M, Hörmann J, Fackler S, Hu Y, Zhou T, Lu L, Ilik I, Aktas T, Feederle R, Hauck SM, et al.122719, Biozol (Eching, Germany); catalog no. 9206; ThermoFisher Scientific (Waltham, MA, USA); clone PA5-66827, and Sigma Aldrich (Deisenhof, Germany); clone SC-35). CD3, CD4, CD8, CD45, and CD63-HRP antibodies

(12) Revealing RCOR2 as a regulatory component of nuclear specklesEpigenetics & chromatinNovember 24, 2021Rivera C, Verbel-Vergara D, Arancibia D, Lappala A, González M, Guzmán F, Merello G, Lee JT, Andrés ME.#2616S), anti-LSD1 (Abcam, ab17721), anti-SON (Thermo Fisher, #PA5-65107), anti-SRRM2 (Thermo Fisher, #PA5-66827), anti-HDAC2 (Abcam, #ab7029) and anti-GAPDH (Cell Signaling, #2118S). Rabbit monoclonal anti-HA (Cell Signaling

(13) Identification of abscission checkpoint bodies as structures that regulate ESCRT factors to control abscission timingeLifeAugust 4, 2021Strohacker LK, Mackay DR, Whitney MA, Couldwell GC, Sundquist WI, Ullman KS.monoclonal),Abcam,Cat#: ab18826 RRID:AB_298608,IF (1:5000) Antibody,anti-SRRM2 (rabbit polyclonal),Thermofisher,Cat#: PA5-66827 RRID:AB_2665182,IF (1:1000) Sequence-based reagent,siNup153,"Mackay et al., 2010",siRNA,GGACUUGUUAGAUCUAGUU Sequence-based

(14) SON and SRRM2 are essential for nuclear speckle formationeLifeOctober 23, 2020Ilik İA, Malszycki M, Lübke AK, Schade C, Meierhofer D, Aktaş T.(monoclonal mouse, Santa Cruz sc-398508), SRRM1 (Abcam, ab221061), SRRM2 (Thermo Fisher Scientific, PA5-66827). Imaging Images were acquired with a Zeiss LSM880 microscope equipped with an AiryScan detector,

(15) RNA is required for the integrity of multiple nuclear and cytoplasmic membrane-less RNP granulesThe EMBO journalJanuary 1, 0001"Decker CJ, Burke JM, Mulvaney PK, Parker R."rabbit anti‐coilin antibody (Santa Cruz sc32860) 1:200, rabbit anti‐SRRM2 (Thermo Fisher/Invitrogen PA5‐66827) 1:200, rabbit anti‐SON (Thermo Fisher/Invitrogen PA5‐65108) 1:200, rabbit anti‐MED1 (Abcam ab64965)

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SRRM2 Antibody from Thermo Fisher Scientific

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SRRM2 Antibody from Thermo Fisher Scientific

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