MyBioSource.com's caspase-9 p10 (I18) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
The activation of the initiator caspase. caspase-9. is regulated by the apoptosome. which is composed of cytochrome c bound to Apaf-1 and dATP (1&2). The apoptosome responds to a diverse array of apoptotic stimuli that initiate the caspase cascade that ultimately results in cell death. The cascade of events starts with the proteolytic cleavage of caspase-9. that then cleaves downstream caspases. caspase-3. -6. and ?7 (1). The apoptotic initiating activity of caspase-9 can be regulated by XIAP. X-linked inhibitor-of-apoptosis protein; through the binding of caspase-9 at it amino terminus while it is bound to the apoptosome (3 & 4). This inhibition of caspase-9 activity has been shown to be relieved by Smac/DIABLO through its interaction with XIAP (3).