GOAT ANTI MOUSE IgM

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FITC conjugated Goat anti mouse IgM antibody (STAR86F) used to label IgM expressing cells in murine kidney by immunofluorescence.
Image caption:
Basophil-derived IL-4 controls T-dependent autoreactive antibody isotype switch in lupus-like disease.
h Representative pictures of kidneys from mice with the indicated genotypes injected with PBS or pristane showing the intensity of anti-IgM staining by immunofluorescence. Scale bar = 200 μm. i Quantification of IgM glomerular deposits in kidneys from the mice described in (g) (n = 5).i Results are from at least three independent experiments and presented as individual values in bars representing the mean values ± s.e.m. i Statistical analyses were done by two way ANOVA followed by Tukey’s multiple comparisons test between the indicated groups. P values are shown above each bracket. NS not significant.

From: Tchen J, Simon Q, Chapart L, Thaminy MK, Vibhushan S, Saveanu L, Lamri Y, Saidoune F, Pacreau E, Pellefigues C, Bex-Coudrat J, Karasuyama H, Miyake K, Hidalgo J, Fallon PG, Papo T, Blank U, Benhamou M, Hanouna G, Sacre K, Daugas E, Charles N.
PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus.
Nat Commun. 2024 Apr 22;15(1):3389.
doi: 10.1038/s41467-024-47691-w.
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