MyBioSource.com's Smac/Diablo (C17) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
Second mitochondrial activator of caspases or Smac/DIABLO can promote apoptosis by relieving the inhibition of caspases by the IAPs (1&2). The other mitochondrial activator of apoptosis is cytochrome c (1). Smac/DIABLO export from the mitochondria into the cytosol can be triggered by cytotoxic drugs. DNA damage. and the ligation of FAS (CD95) death receptor (3). Once in the cytosol Smac/DIABLO eliminates the inhibitory effects of the IAPs through and amino terminal interaction with the IAP proteins. and thus allow the activation of caspases (2&4). The interaction of Smac/DIABLO?s amino terminus with the IAP proteins has been localized to their BIR domains. for XIAP the key domain is BIR3 (4&5).