Description
Oct1 and Oct2 are transcription factors of the POU homeo-domain family that bind to the Ig gene octamer sites, regulating Bcell-specific genes. The function of these transcription factors is dependent on the activity of B-cell-restricted coactivators such as BOB.1/OBF.1.Absence of functional Oct-2 and Bob-1 cells represents a novel mechanism for immunoglobulin gene deregulation