Description
STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. The phosphorylation of STAT1 at Tyr701 induces STAT1 dimerization, nuclear translocation and DNA binding. STAT 1 is activated by a number of different ligands, including IFN, EGF, PDGF and IL6. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions