MyBioSource.com's HDAC3 (C18) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The HDAC3 (C18) Antibody was generated using HDAC3, and Histone Deacetylase 3 as the antigen and it reacts with Human, Mouse, Rat, and Chicken/Bird.
Description
Histone deacetylases (HDACs) catalyze the removal of the acetyl modification on lysine residues of proteins. that includes the core nucleosomal histones H2A. H2B. H3. and H4 (1). HDACs together with HATs regulate the level of acetylation of the histones (1.2). The level of acetylation of nucleosomal histones plays a key regulatory role in the transcription of many genes (1.3). The repression of gene transcription is associated with the hypoacetylation of histones. while hyperacetylated histones are associated with the activation of transcription (1). Three classes of HDACs have been described and class I and II HDACs are structurally related. Class I HDACs consist of HDAC1. 2. 3. and 8. Class II HDACs consist of HDAC4. 5. 6. 7. 9. and 10. Class III HDACs are structurally unrelated to the human class I and II HDACs. and consist of homologues of the yeast Sir2 proteins (1).