MyBioSource.com's HspBP1 (FL4) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The HspBP1 (FL4) Antibody was generated using HSPBAP1, and Miscellaneous as the antigen and it reacts with Human.
Description
HspBP1 is an Hsp70-interacting protein that was first isolated from a human heart cDNA library using the yeast two-hybrid system (1). The ATPase domain of Hsp70 binds HspBP1 and upon binding inhibits Hsp70 chaperone activity. More recently HspBP1 was found to be a homologue of the yeast Fes1 and Sls1 proteins and promotes nucleotide dissociation from Hsc70. HspBP1 has also been shown to strip nucleotide from yeast Ssa1p. making it a member of the class of nucleotide exchange factors that exhibit varying degrees of compartment and species specificity (2). HspBP1 is highly expressed in heart. brain. skeletal muscle. and pancreas tissues. It is also expressed in pancreatic. hepatic. and astrocytic cell lines.