PLCgamma1 (D9H10) XP ® Rabbit mAb 5690T from Cell Signaling Technology

Product Specs
ItemPLCgamma1 (D9H10) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $155.00 Inquire
Catalog Number5690T
Quantity20 µl
ApplicationsW, W-S, IP, IHC-P
ReactivityH, M, R, Mk
TargetPLCg1
IsotypeIgG
HostRabbit
NCBI Full Gene Namephospholipase C gamma 1
NCBI Gene AliasesNCKAP3, PLC-II, PLC1, PLC148, PLCgamma1
ClonalityMonoclonal
Research AreaCa, cAMP and Lipid Signaling
Molecular Weight150 kDa

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapyCell Death DiscoveryMarch 6, 2026Zhenjun Li, Liangcheng Lv, Xiaoyu Yao, Zhiwei Feng, Yan Xie, Kecheng Li, Feifei Qi, Mei Yang, Jingwen Wang, Tao Pan, et al.Laboratories (#200102, Shanghai, China) was used to detect CAR-T cells. Phospho-Ser1248-PLCγ1 (#8713), PLCγ1 (#5690), TCF1 (#2203), NR4A (#3960), NFAT1 (#5861), Tox (#36778), BATF (#8638), TNF-a (#3707), LAG3 (#15372)

(2) Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumorsScience AdvancesJanuary 23, 2026Corinne E. Decker, Jacqueline Idun, Katja Mohrs, Thomas Craig Meagher, Iryna Petriv, Jonathon Golas, Robert Salzler, Timothy Helms, Dharani Ajithdoss, Suhasini Avvaru, et al.(Cell Signaling Technology, 3584), total LAT (Cell Signaling Technology, 45533), total PLCγ1 (Cell Signaling Technology, 5690) and β-actin (Santa Cruz Biotechnology, sc-47778). All Western blotting reagents are listed in table

(3) Engineered fibroblast growth factor 1 variants uncouple glucose-lowering effects from mitogenic activity with therapeutic potential for type 2 diabetesMolecular BiomedicineJanuary 11, 2026Aleksandra A. Czyrek, Daniel Krowarsch, Szymon Sidor, Michal Janiszewski, Ewa Drzazga-Wilk, Katarzyna Bazydlo-Guzenda, Pawel Buda, Jerzy Pieczykolan, Natalia Porebska, Marta Minkiewicz, et al.(pFRS2) (#3864), anti-vinculin (#13901), anti-phospho-PLCγ1 (Tyr783) (pPLCγ) (#14,008), anti-PLCγ1 (#5690), anti-Glut1 (#73,015) and anti-FGF1 (#3139) from Cell Signaling Technology. Horseradish peroxidase-conjugated

(4) Natural killer cell-specific chimeric antigen receptor enhances CAR NK cell functions and anti-tumor activityTheranosticsNovember 6, 2025Changqing Pan, You Zhai, Zhongliang Cui, Yiyun Yin, Menghui Xu, Di Wang, Yishuo Sun, Jiazheng Zhang, Chen Wang, Ziwei Li, et al.ab185633), PLCγ1 (Tyr783; Cell Signaling Technology, Cat# 2821), PLCγ1 (Cell Signaling Technology, Cat# 5690), PLCγ2 (Tyr1217; Cell Signaling Technology, Cat# 3871), PLCγ2 (Cell Signaling Technology, Cat# 3872),

(5) Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumorsThe EMBO JournalOctober 31, 2025Jacopo Boni, Míriam Fernández-González, HyeRim Han, Carla Roca, Cassandra J Wong, Cristina Rioja, Clara Nogué, Leticia Manen-Freixa, Jonathan Boulais, Endika Torres-Urtizberea, et al.#F3165), anti-FGFR1 (Abcam #ab76464), anti-phospho-FGFR1 Tyr653/654 (CST #52928), anti-PLCγ1 (CST #5690), anti-phospho-PLCγ1 Tyr783 (CST #2821), anti-ERK1/2 (CST #9102S), anti-phospho-ERK1/2 Thr202/Tyr204

(6) Reprogramming CD8+ T-cell Branched N- Glycosylation Limits Exhaustion, Enhancing Cytotoxicity and Tumor KillingCancer Immunology ResearchOctober 1, 2025Catarina M. Azevedo, Bingxian Xie, William G. Gunn, Ronal M. Peralta, Carolina S. Dantas, Henrique Fernandes-Mendes, Supriya Joshi, Victoria Dean, Pedro Almeida, Drew Wilfahrt, et al.(1:1000, clone D25A9, catalog number 13349S, Cell signaling) and PCLγ (1:1000, clone D9H10, catalog number 5690T, Cell signaling). Membrane was then incubated with secondary antibody (anti-rabbit horseradish peroxidase,

(7) Glucose-dependent glycosphingolipid biosynthesis fuels CD8+ T cell function and tumor controlCell MetabolismSeptember 2, 2025Joseph Longo, Lisa M. DeCamp, Brandon M. Oswald, Robert Teis, Alfredo Reyes-Oliveras, Michael S. Dahabieh, Abigail E. Ellis, Michael P. Vincent, Hannah Damico, Kristin L. Gallik, et al.,Cell Signaling Technology,Cat# 14008; RRID: AB_2728690 Rabbit monoclonal anti-PLCγ1 (D9H10),Cell Signaling Technology,Cat# 5690; RRID: AB_10691383 Rabbit monoclonal anti-phospho-c-JUN (Ser73) (D47G9),Cell Signaling Technology,Cat#

(8) Caffeine Acts as an Agonist of Siglec‐6, Inhibits MRGPRX2‐Triggered Mast Cell Degranulation and Anaphylactoid ReactionsMediators of InflammationAugust 30, 2025Yuanyuan Ding, Na Wang, Chenrui Zhao, Hongfen Du, Yujuan Yuan, Tao Zhang, Hongli An(p-SHP-1; 1:1000, #ab41436) from Abcam; anti-Siglec-6 (1:1000, ab317307) from Abcam; anti-PLCγ (1:1000, #5690) from CST; anti-phosphorylated PLCγ1 (p-PLCγ1; Ser1248) (1:1000, #8713) from CST; anti-IP3R (1:1000,

(9) Hyperactive PLCG1 induces cell-autonomous and bystander T cell activation and drug resistanceEMBO ReportsAugust 12, 2025Longhui Zeng, Xinyan Zhang, Yiwei Xiong, Kazuki Sato, Nicole Hajicek, Yasunori Kogure, Keisuke Kataoka, Seishi Ogawa, John Sondek, Xiaolei SuBlocking antibody" Anti-pERK,Cell Signaling,"Cat#9101, WB (1:2000)" Anti-PLCG1,Cell Signaling,"Cat#5690, WB (1:2000)" Anti-PLCG1 pY783,Cell Signaling,"Cat#2821, WB (1:2000)" Anti-alpha-SMA,R&D Systems,"Cat#MAB1420,

(10) Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificityCellMay 1, 2025Taisuke Kondo, François X. P. Bourassa, Sooraj Achar, Justyn DuSold, Pablo F. Céspedes, Makoto Ando, Alka Dwivedi, Josquin Moraly, Christopher Chien, Saliha Majdoul, et al.onto PVDF membranes. Membranes were immunoblotted by the sequential stainings with anti-PLC-γ1 (D9H10, 5690S) and anti-phospho-PLC-γ1 (D6M9S, 14008S, Cell Signaling Technology) rabbit antibodies (1:1,000), or

(11) Roles of Annexin A1 Expression in Small Cell Lung CancerCancers (Basel)April 23, 2025Ágnes Paál, David Dora, Ákos Takács, Christopher Rivard, Shivaun Lueke Pickard, Fred R. Hirsch, Brigitta Roskó, Peter Kiraly, Péter Ferdinandy, Zoltán V. Varga, et al.hematoxylin. For double IF staining, primary antibodies for CD45 (#40763, abcam), CD68 (#303565, abcam), CD3 (#5690, abcam), CD19 (#90176, Cell Signaling), vimentin (#MA5-11883, Invitrogen), and ANXA1 (#32934, Cell Signaling)

(12) PRL2 negatively regulates FcεRI mediated activation of mast cellsCell death & diseaseApril 21, 2025Guo X, Lei Y, Xu Y, Du X, Lin L, Luo Y, Xi Y, Guo Y, Niu X, Wang Z, et al.4228, 1:1000), rabbit anti-PI3 kinase p85 antibody (CST, 4257, [19H8], 1:1000), rabbit anti-PLCγ1 (CST, 5690, [D9H10], 1:1000), rabbit anti-VAMP-8 (Proteintech, 15546-1-AP, 1:1000), rabbit anti-SNAP-23 (Proteintech,

(13) Restoration of LAT activity improves CAR T cell sensitivity and persistence in response to antigen-low acute lymphoblastic leukemiaCancer CellMarch 10, 2025Catherine Pham-Danis, Amanda J. Novak, Etienne Danis, Samantha M. McClellan, Lillie Leach, Michael C. Yarnell, Christopher C. Ebmeier, Sarah K. Tasian, M. Eric KohlerAb4476 Phospho-PLCγ1 (Tyr783),Cell Signaling,Cat# 2821 PLCγ1 (Clone D9H10) XP,Cell Signaling,Cat# 5690 Alpha-tubulin (Clone DM1A),ThermoFisher,Cat# A11136 Beta-actin (Clone OTI1),Origene,Cat# TA811000 Goat Anti-Mouse IgG (H + L)-HRP Conjugate

(14) Fermented plant product (FPP) suppresses immediate hypersensitivity reactions with impaired high-affinity IgE receptor (FcεRI) signalingCytotechnologyFebruary 25, 2025Tomoki Kodama, Ayana Yokoyama, Yuki Nishioka, Riku Kawasaki, Aiko Teshima, Akira Maeda, Ayano Hojo, Takumi Suizu, Hideto Torii, Kotaro Fujioka, et al.#13198, 1:1250 dilution), anti-phospho-Syk (pSyk, pTyr 525/526) mAb (#2710, 1:1000), anti-PLCγ1 mAb (#5690, 1:1000), anti-phospho-PLCγ1 (pPLCγ1, pTyr 783) mAb (#2821, 1:1000), anti-PI3 kinase (PI3K) p85 mAb

(15) Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancerNature communicationsFebruary 22, 2025Yang X, Ma X, Zhao T, Croucher DR, Nguyen EV, Clark KC, Hu C, Latham SL, Bayly-Jones C, Nguyen BV, et al.Phospho-Akt Substrate (RXXS*/T*) (cat. 9614), T-CAMK2 (cat. 4436), CAMK2-pT287 (cat. 12716), PLC-γ (cat. 5690S), PLC-γ-pY783 (cat.14008S) and cleaved PARP Asp 214 (cat. 9546) were purchased from Cell Signalling

(16) Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopyeLifeNovember 8, 2024Mitsuhiro Abe, Masataka Yanagawa, Michio Hiroshima, Toshihide Kobayashi, Yasushi Sakoprimary antibody and HRP-linked anti-rabbit IgG. PLCG1 was detected using anti-PLCγ1 (RRID:AB_10691383; #5690, Cell Signaling Technology; 1:500) as the primary antibody and HRP-linked anti-rabbit IgG. Phosphorylated

(17) A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complexCell communication and signaling : CCSOctober 30, 2024Hong S, Kim K, Shim YR, Park J, Choi SE, Min H, Lee S, Song JJ, Kang SJ, Jeong WI, et al.(Santa Cruz Biotechnology); HA (MMS-101R, Biolegend); GST (2622), β-actin (4970), phospho-PLCγ1 (Tyr783) (2821), PLCγ1 (5690), phospho-Src family (Tyr416) (6943), Src (2108), phospho-PKCθ (Thr538) (9377), PKCθ (13643) (Cell Signaling Technology

(18) Development and Application of Rapamycin-regulated Tyrosine PhosphatasesJournal of Visualized ExperimentsSeptember 6, 2024Barbara N. Szynal, Hanna Bradford-Olson, Andrei V. KarginovAntibody,Millipore-Sigma,05–1143, Anti-phospho-PLCγ Y783 Antibody,Cell Signaling,14008, Anti-PLCγ Antibody,Cell Signaling,5690, Materials

(19) PLCγ1 deficiency in chondrocytes accelerates the age‐related changes in articular cartilage and subchondral boneJournal of Cellular and Molecular MedicineAugust 19, 2024Qiubo Zhao, Xiaolei Chen, Ning Qu, Jinhua Qiu, Bing Zhang, Chun Xiaovernight Agg,Proteintech Cat No. 13880‐1‐AP,1:100 (IHC) 1:1000 (WB),4°C overnight PLC‐γ1,Cell Signalling Technology #5690,1:100 (IHC) 1:1000 (WB),4°C overnight p‐PLC‐γ1 (Tyr783),Cell Signalling Technology #2821,1:100 (IHC)

(20) Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2Acta Biochimica et Biophysica SinicaAugust 7, 2024Yong Ji, Yang Wang, Jiacheng Zou, Guanghao Liu, Mingyu Xia, Jun Ren, Daorong Wangantibody directed against DNMT3B (57868, 1:100; Cell Signaling Technology, Beverly, USA) or PLCG2 (5690, 1:150; Cell Signaling Technology) and then with a biotin-conjugated secondary antibody (SA1050; Boster,

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PLCgamma1 (D9H10) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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PLCgamma1 (D9H10) XP ® Rabbit mAb from Cell Signaling Technology

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