Fig 2: Immunofluorescence experiments using anti-LRP2 nephropathy and control patient serum. a Indirect immunofluorescence using the anti-LRP2 nephropathy patient’s serum on a normal human kidney section, showing positive IgG staining along the proximal tubule brush border. b Indirect immunofluorescence using the IgA nephropathy patient’s serum on a normal human kidney section, showing negative IgG staining

Fig 3: Immunofluorescence performed on cryosections of normal human kidney tissue. a Staining for LRP2 using a rabbit antibody along the apical membrane of the proximal tubular epithelium. b Indirect immunofluorescence of serum from a patient with anti-LRP2 nephropathy on a normal human kidney. c Strong colocalization of LRP2 and serum antibodies