Notch3 (D11B8) Rabbit mAb 5276S from Cell Signaling Technology

Product Specs
ItemNotch3 (D11B8) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number5276S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetNotch3
HostRabbit
NCBI Gene AliasesCADASIL, CADASIL1, CASIL, IMF2, LMNS
ClonalityMonoclonal
NCBI Full Gene Namenotch receptor 3
Research AreaDevelopmental Biology
IsotypeIgG
CloneD11B8
Molecular Weight90, 270

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Endothelial cells regulate mesangial cells through the Dll4/Notch3 axis to participate in glomerular injury in lupus nephritisFrontiers in ImmunologyMarch 13, 2026Haixia Guo, Yueying Mao, Yongjun Wang, Bin Yu, Zhifeng Gu, Chun Yao, Zhanyun Daovernight incubation with primary antibodies at 4 °C. Primary antibodies used included: Notch3 (CST, 5276S, 1:1000), Hey1 (Proteintech, 19929-1-AP, 1:1000), Hey2 (Proteintech, 105791-1-AP, 1:1000), and β-tubulin

(2) MUC1-C auto-regulatory complex with EBNA1 is responsible for latent Epstein-Barr virus-associated gastric cancer progressionOncogeneOctober 7, 2025Hiroki Ozawa, Yin Wang, Henry G. Withers, Naoki Haratake, Ayako Nakashoji, Atrayee Bhattacharya, Atsushi Fushimi, Chie Kikutake, Kazuhiro Yamanoi, Shaowen White, et al.Cruz), anti-NOTCH1 (3608, 1:1000 dilution; CST), anti-NOTCH2 (5732, 1:1000 dilution; CST), anti-NOTCH3 (5276, 1:1000 dilution; CST), anti-HEY1 (19929-1-AP, 1:2,000 dilution; Proteintech), anti-α-Tubulin (2144,

(3) Molecular impact of NOTCH signaling dysregulation on ovarian cancer progression, chemoresistance, and taxane responseBiomedicine & PharmacotherapyOctober 1, 2025Kamila Koucka, Alzbeta Spalenkova, Karolina Seborova, Tereza Tesarova, Marie Ehrlichova, Ivona Krus, Petr Holy, Lukas Rob, Martin Hruda, Jiri Bouda, et al.cat no. A3853, Sigma Aldrich) as a control, along with NOTCH3 (rabbit monoclonal antibody, D11B8, #5276 Cell signaling, Danvers, Massachusetts, USA). The secondary antibodies used were IRDye® 800CW Goat anti-Rabbit

(4) Identification of gastric cancer stem cells with CD44 and Lgr5 double labelling and their initial roles on gastric cancer malignancy and chemotherapy resistanceCell Biology and ToxicologyDecember 21, 2024Zhida Chen, Yunhe Gao, Pengfei Zhang, Yi Liu, Bo Wei, Lin Chen, Hongqing XiGli1, 1:1000, 3538; Smo, 1:1000, 92,981; Notch 1, 1:1000, 3608; Notch 2, 1:1000, 5732; Notch 3, 1:1000, 5276; Notch 4, 1:1000, 2423; NICD, 1:1000, 4147; Smad 1, 1:1000, 6944; Smad 2, 1:1000, 5339; Smad 3, 1:1000,

(5) Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progressionNature communicationsNovember 12, 2024He Y, Yang F, Yang L, Yuan H, You Y, Chen Y, Wu X, Min H, Chen J, Li C.ab268020, 1:1000), anti-collagen type I (Cat: 14695-1-AP, Proteintech, 1:1000), anti-Notch3 (D11B8, Cat: 5276T, Cell Signaling Technology, 1:1000). anti-β-Actin (13E5, Cat:4970S, Cell Signaling Technology, 1:5000)

(6) Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to RadiotherapyCancer DiscoveryOctober 4, 2024Abrar Choudhury, Martha A. Cady, Calixto-Hope G. Lucas, Hinda Najem, Joanna J. Phillips, Brisa Palikuqi, Naomi Zakimi, Tara Joseph, Janeth Ochoa Birrueta, William C. Chen, et al.using Pierce ECL substrate (32209, Thermo Fischer Scientific). Primary antibodies recognizing NOTCH3 (5276, Cell Signaling, 1:1000) or GAPDH (8245, Abcam, 1:5000) and secondary antibodies recognizing mouse (7076,

(7) Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancerCell death & diseaseMay 25, 2024Standing D, Dandawate P, Gunewardena S, Covarrubias-Zambrano O, Roby KF, Khabele D, Jewell A, Tawfik O, Bossmann SH, Godwin AK, et al.KLF4 (12173S), p-p65 (13346S), p65 (8242S), p-p38 (9216S), p38 (8690S), Notch-1 (3608S), and Notch-3(5276S) were purchased from Cell Signaling Technologies (Danvers, Massachusetts). IRAK1-T209 (SAB4504246-100UG)

(8) The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motifCell Death & DiseaseMay 14, 2024Xiaolei Huang, Cheng Zhang, Xinci Shang, Yichang Chen, Qin Xiao, Zhengguo Wei, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Jinrong Min, et al.(Sigma-Aldrich, Cat# H6908, 1:1000), rabbit monoclonal anti-NOTCH3 antibody (Cell Signaling Technology, Cat# 5276, 1:1000), rabbit monoclonal anti-H3K4me3 antibody (Cell Signaling Technology, Cat# 9751, 1:1000), rabbit

(9) Identification of MUC1-C as a Target for Suppressing Progression of Head and Neck Squamous Cell CarcinomasCancer Res CommunMay 14, 2024Nakashoji A, Haratake N, Bhattacharya A, Mao W, Xu K, Wang K, Daimon T, Ozawa H, Shigeta K, Fushimi A, et al.anti-∆Np63 (619002, 1:1,000 dilution; BioLegend), anti-SOX2 (3579, 1:1,000 dilution; CST), anti-NOTCH3 (5276T, 1:1,000 dilution, CST), anti-HEY1 (19929-1-AP, 1:2,000 dilution; Proteintech), anti-JAG1 (2620T, 1:1,000

(10) NOTCH3 inhibits transcription factor ZEB1 expression and metastasis of breast cancer cells via transcriptionally upregulating miR-223J CancerJanuary 1, 2024Wen-Jia Chen, Hui-Ting Zhong, Hua-Tao Wu, Yan-Yu Hou, Zheng Wu, Ze-Xuan Fang, Jing LiuAntibody,Company,Source,KDa,Article number,Dilution rate Notch3,CST,Rabbit,"270, 90",#5276,1:1000 E-cadherin,CST,Rabbit,110,#3195,1:2000 Vimentin,CST,Rabbit,57,#5741,1:1000 ZEB1,CST,Rabbit,200,#3396,1:500 β-actin,Santa,Mouse,42,TA-09,1:3000 Antibody

(11) Notch3 restricts metastasis of breast cancers through regulation of the JAK/STAT5A signaling pathwayBMC CancerDecember 20, 2023Min-Na Chen, Ze-Xuan Fang, Zheng Wu, Jing-Wen Bai, Rong-Hui Li, Xiao-Fen Wen, Guo-Jun Zhang, Jing Liuby 10% SDS-PAGE, and transferred to a PVDF membrane (Millipore, MA). Primary antibodies for Notch3 (5276S), E-cadherin (3195S), Vimentin (5471S), and β-actin (3700S) were purchased from Cell Signaling Technology

(12) Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasionCell proliferationDecember 1, 2023Lyu C, Ni T, Guo Y, Zhou T, Chen ZJ, Yan J, Li Y.β‐catenin (1:1000, #19807, CST), β‐catenin (1:1000, #8480, CST), NOTCH 1–3 (1:1000, #3608, #5732, #5276, CST) or transcription factor 4 (TCF4; 1:1000, #2565, CST) at 4°C overnight. All antibodies were diluted

(13) A SNAI2/CTCF Interaction is Required for NOTCH1 Expression in RhabdomyosarcomaMolecular and Cellular BiologyNovember 17, 2023Prethish Sreenivas, Long Wang, Meng Wang, Anil Challa, Paulomi Modi, Nicole Rae Hensch, Berkley Gryder, Hsien-Chao Chou, Xiang R. Zhao, Benjamin Sunkel, et al.RRID:AB_2239535" NOTCH1,CST,"Cat# 3608, RRID:AB_2153354" NOTCH2,CST,"Cat# 4530, RRID:AB_10860068" NOTCH3,CST,"Cat# 5276, RRID:AB_10560515" CTCF,CST,"Cat# 2899, RRID:AB_2086794" Myosin Heavy Chain,DSHB,"Cat# MF 20, RRID:AB_2147781" MEF2C

(14) A conserved mechanism for JNK-mediated loss of Notch function in advanced prostate cancerScience signalingNovember 7, 2023Wang CW, Clémot M, Hashimoto T, Diaz JA, Goins LM, Goldstein AS, Nagaraj R, Banerjee U.anti-Notch2 (1:1000; Cell Signaling Technology #5732), rabbit anti-Notch3 (1:1000; Cell Signaling Technology #5276), mouse anti-Notch4 (1:1000; Cell Signaling Technology #2423), mouse anti-alpha-tubulin (1:100; Developmental

(15) Enhancer remodeling activates NOTCH3 signaling to confer chemoresistance in advanced nasopharyngeal carcinomaCell death & diseaseAugust 10, 2023Liu L, Deng P, Liu S, Hong JH, Xiao R, Guan P, Wang Y, Wang P, Gao J, Chen J, et al.BSA, followed by primary antibody incubation overnight. The primary antibodies used were: NOTCH3 (CST, 5276), SLUG (CST, 9585), Actin (CST, 4359) and GAPDH (CST, 2118). The secondary antibodies used were horseradish

(16) NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapybioRxiv : the preprint server for biologyJuly 11, 2023Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, et al.using Pierce ECL substrate (32209, Thermo Fischer Scientific). Primary antibodies recognizing NOTCH3 (5276, Cell Signaling, 1:1000) or GAPDH (8245, Abcam, 1:5000) and secondary antibodies recognizing mouse (7076,

(17) Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancerCell Death & DiseaseFebruary 28, 2023Sonia Brahim, Ana-Maria Negulescu, Clara Geneste, Thomas Schott, Shuheng Lin, Louis-Oscar Morel, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Patrick Mehlen, et al.5% milk. The following primary antibodies were used: anti-Notch3 (1:1000 dilution, Cell Signaling #5276 (D11B8)), anti-HA (1:5000 dilution, Sigma H4908) and anti-actin (1:5000 dilution, Sigma A3854). Soft-agar

(18) NOTCH Signaling Limits the Response of Low-Grade Serous Ovarian Cancers to MEK InhibitionMolecular cancer therapeuticsDecember 2, 2022Llaurado Fernandez M, Hijmans EM, Gennissen AMC, Wong NKY, Li S, Wisman GBA, Hamilton A, Hoenisch J, Dawson A, Lee CH, et al.8408), pT359RSK (No. 8753), SHOC2 (No. 53600), cleaved NOTCH1 (No. 2421), NOTCH2 (No. 4530), NOTCH3 (No. 5276), and NOTCH4 (No. 2423) were from Cell Signaling Technology and MAML2 (A300-682) was obtained from Bethyl

(19) Leptin modulated microRNA-628-5p targets Jagged-1 and inhibits prostate cancer hallmarksScientific ReportsDecember 1, 2022Leslimar Rios-Colon et al.2155S), anti-Hes-1 (Cat #11988S), anti-Notch1(Cat #3608S), anti-Notch2 (Cat #5732S), anti-Notch3 (Cat #5276S), anti-E-cadherin (Cat #3195S), anti-N-cadherin (Cat #13116S), anti-PARP (Cat #9542P), anti-cleaved

(20) NICD3 regulates the expression of MUC5AC and MUC2 by recruiting SMARCA4 and is involved in the differentiation of mucinous colorectal adenocarcinomaMolecular oncologyOctober 1, 2022Yan X, Cheng Y, Zhang X, Hu Y, Huang H, Ren J, Wen B, Yang Y, Xiao K, Hu W, et al.centrifugation at 2000 g for 5 min at 4 °C. Then, the supernatant was taken and incubated with anti‐NOTCH3 (5276S; Cell Signaling Technology) or anti‐SMARCA4 (52251S; Cell Signaling Technology) antibody at the ratio

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Notch3 (D11B8) Rabbit mAb

Notch3 (D11B8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Notch3 (D11B8) Rabbit mAb from Cell Signaling Technology

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