FRA1 (D80B4) Rabbit mAb 5281S from Cell Signaling Technology

Product Specs
ItemFRA1 (D80B4) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number5281S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH
TargetFRA1
IsotypeIgG
HostRabbit
NCBI Gene AliasesFRA, FRA1, fra-1
NCBI Full Gene NameFOS like 1, AP-1 transcription factor subunit
CloneD80B4
Molecular Weight40
ClonalityMonoclonal
Research AreaMAP Kinase Signaling

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Human pancreatic progenitor organoids define genetic and epigenetic barriers to early PDAC transformationDev CellMay 19, 2026Xian Zhang, Wilfred Wong, Hyein S. Cho, Dapeng Yang, Gary Dixon, Renhe Luo, Dingyu Liu, Denis Torre, Shigeaki Umeda, Federico González, et al.,Santa Cruz,"Cat# sc-28310, RRID:AB_627632" Rabbit monoclonal FOSL1 (WB),Cell Signaling Technologies,"Cat# 5281, RRID:AB_10557418" "Rabbit polyclonal FOSL2 (IHC, WB, IF, C&R)",Sigma-Aldrich,"Cat# HPA004817, RRID:AB_1849014" "Rabbit

(2) Epigenetic context defines the transcriptional activity of canonical and noncanonical NF-κB signaling in pancreatic cancerCell Death DiscoveryMarch 17, 2026Joana E. Aggrey-Fynn, Joshua Busch, Dominik Saul, Ashish Rajput, Kerstin Willecke, Meghana Manjunath, Nicole Klimt, Kothai Rajendran, Nadine Schacherer, Wanwan Ge, et al.Antibodies included H3K27ac (1μg; C15410196, Diagenode; RRID:AB_2637079), FOSL1 (D80B4) (FRA-1) (5 μl; 5281; Cell Signaling; RRID:AB_10557418), RELA (NFκB p65 L8F6) (5 μl; 6956; Cell Signaling; RRID:AB_10828935),

(3) The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate CancerCancer ResMarch 2, 2026Srushti Kittane, Erik Ladewig, Taibo Li, Jillian R Love, Ryan Blawski, Yangzhenyu Gao, Amaia Arruabarrena-Aristorena, Peihua Zhao, Susan L. Dalrymple, Huayang Liu, et al.Histone H3 (di methyl K4) antibody [Y47] (Abcam Cat# ab32356, RRID: AB_732924), FRA1/FOSL1 [D80B4] (Cell Signaling Technology Cat# 5281, RRID: AB_10557418). ChIP-qPCRs were done with a rabbit IgG control (Abcam Cat# ab171870, RRID: AB_2687657). The

(4) Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell disseminationbioRxivFebruary 8, 2026Pietro Berico, Cody Dunton, Luay Almassalha, Amanda Flores Flores-Yanke, Karla I. Medina, Nicolas Acosta, Tara Muijlwijk, Catherine Do, Soobeom Lee, Sharon N Edmiston, et al.primary antibodies against CTCF (Cell Signaling Technology, #2899), FOSL1 (Cell Signaling Technology, #5281), FOSL2 (Cell Signaling Technology, #19967), c-JUN (Cell Signaling Technology, #9165), pan-TEAD (Cell Signaling Technology

(5) Knockdown of LncRNA CCAT1 Attenuates ox-LDL-Induced Inflammation in THP1-Derived Macrophages via the miR-296-3p/FOSL1 AxisCardiovasc TherDecember 22, 2025Haiping Zhang, Feng Liu, Guihua Miao, Yijiao Wang, Lijun Zhang, Chun Yang, Kai Huang, Fengyun Guo, JunBo An, Binfeng He, et al.from ZETA LIFE (San Francisco, United States). The antibodies used were anti‐FOSL1 Antibody (CST, #5281), anti‐NLRP3 Antibody (CST, # 15101), anti‐Phospho‐NF‐κB p65 (Ser536) (p‐p65) (CST, #3033), anti‐NF‐κB p65

(6) A novel super-enhancer-driven lncRNA LINC00973 governs head and neck squamous cell carcinoma progression through EN2Cell Death & DiseaseDecember 19, 2025An Wang, Pengfei Diao, Na Xiao, Yuxiang Wei, Yaping Wu, Yanling Wang, Xuejing Wang, Enshi Yan, Hongbing Jiang, Jin Li, et al.BRD4 (1:50, #13440, Cell signaling, USA), EP300 (1:50, #86377, Cell signaling, USA), FOSL1 (1:50, #5281, Cell signaling, USA) or normal mouse IgG (1:50, #68860, Cell signaling, USA). Detailed ChIP-qPCR primer

(7) MAP3K1/MAP2K4 mutations drive breast cancer progression by compensating for TP53 loss through inactivation of the JNK2-p53-FOSL1 axisBreast Cancer ResearchDecember 16, 2025Sike Hu, Ailing Ji, Manxue Wang, Xia Li, Lili Sun, Ruifang Gao, Ying Zhang1:1000),JNK2 (CST #9258, 1:1000), Phospho-p53 (Ser15) (CST #9284, 1:800), MKK4(CST #9152, 1:1000), FRA1 (CST #5281, 1:500), β-Actin (CST #4967, 1:2000) as loading control. After washing, membranes were incubated with

(8) The Histone Methyltransferase KMT2D is a Critical Mediator of Lineage Plasticity and Therapeutic Response in Castration Resistant Prostate CancerCancer ResearchDecember 11, 2025Srushti Kittane, Erik Ladewig, Taibo Li, Jillian R. Love, Ryan Blawski, Yangzhenyu Gao, Amaia Arruabarrena-Aristorena, Peihua Zhao, Susan L. Dalrymple, Huayang Liu, et al.Histone H3 (di methyl K4) antibody [Y47] (Abcam Cat# ab32356, RRID: AB_732924), FRA1/FOSL1 [D80B4] (Cell Signaling Technology Cat# 5281, RRID: AB_10557418). ChIP-qPCRs were done with a rabbit IgG control (Abcam Cat# ab171870, RRID: AB_2687657). The

(9) Neutrophil extracellular traps–STC1 positive feedback loop promotes immune evasion and metastasis in bladder cancerJournal for ImmunoTherapy of CancerNovember 28, 2025Tingting Cai, Tao Feng, Wei Zhang, Qintao Ge, Liangju Peng, Yue Wang, Jindong Xie, Xinpei Deng, Wenkai Zhu, Shengming Jin, et al.(1:1,000; sc-293435, Santa Cruz); calreticulin (CRT) (1:3,000; 27 298–1-AP, Proteintech); FosL1 (1:1,000; 5281, CST); MEK1/2 (1:1,000; 9122, CST); p-MEK1/2 (1:1,000; 9154, CST); ERK1/2 (1:1,000; 4695, CST); p-ERK1/2

(10) Single-cell transcriptomics identifies FOSL1-regulated IGFBP3+ melanoma subtype as a neuro-immunoregulatory signaling hub facilitating tumor progressionFrontiers in ImmunologyNovember 26, 2025Wenjia Ge, Ziwei Zhang, Wenjie Chen, Zhijie Zhao, Huabao Cai, Yantao Ding, Jin XuSubsequently, the membranes were treated with the primary antibody (Cell Signaling Technology, Cat# 5281 for FOSL1; Cat# 5174 for GAPDH) overnight at 4 °C, followed by a one-hour incubation with a horseradish

(11) Characterization of Drug-Tolerant Persister Cells in Triple-Negative Breast Cancer Identifies a Shared Persistence Program across Treatments and PatientsCancer ResNovember 6, 2025Léa Baudre, Grégoire Jouault, Pacôme Prompsy, Melissa Saichi, Sarah Gastineau, Christophe Huret, Laura Sourd, Ahmed Dahmani, Elodie Montaudon, Florent Dingli, et al.(Active Motif, ref. 53160) was used with 1:50 Anti-Rabbit antibodies for FOSL1 (Cell Signaling, ref. #5281, RRID: AB_10557418), HA (Epicypher, ref. 13-2010, RRID: AB_3094663) and H3K27ac (Cell Signaling, ref.

(12) Characterization of Drug-Tolerant Persister Cells in Triple-Negative Breast Cancer Identifies a Shared Persistence Program across Treatments and PatientsCancer ResearchNovember 6, 2025Léa Baudre, Grégoire Jouault, Pacôme Prompsy, Melissa Saichi, Sarah Gastineau, Christophe Huret, Laura Sourd, Ahmed Dahmani, Elodie Montaudon, Florent Dingli, et al.(Active Motif, ref. 53160) was used with 1:50 Anti-Rabbit antibodies for FOSL1 (Cell Signaling, ref. #5281, RRID: AB_10557418), HA (Epicypher, ref. 13-2010, RRID: AB_3094663) and H3K27ac (Cell Signaling, ref.

(13) FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networksFrontiers in Cell and Developmental BiologySeptember 22, 2025Wuroud Al-Khayyat, Taylor Laframboise, Jessica Dougherty, Marc S. Mendonca, Douglas R. Boreham, T. C. Tai, Christopher Thome, Sujeenthar Tharmalingamthe following primary rabbit monoclonal antibodies overnight at 4 °C: FRA1 (1:1,000; Cell Signaling #5281T) and cFOS (1:500; Cell Signaling #2250S). The blots were washed four times with TBS-T and incubated

(14) Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancerRedox BiolAugust 19, 2025Min Guo, Yan-Jing Wang, Jie Shi, Li-Xia Cao, Yang Ou, Xiao Jia, Chun-Chun Qi, Zhao-Xian Li, Yu-Xin Liu, Si-Yu Zuo, et al.Chip; Servicebio, GB11513 for IHC), anti-acetylated lysine (Cell Signalling, 9441), CBP (PTM-bio, PTM-5281), CBP-1535Ac (Cell Signalling, 4771), SIRT1 (Proteintech, 60303-1-Ig), V5 (Cell Signalling, 13202 for WB

(15) CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor-driven proteome through PARP7 activityProc Natl Acad Sci U S AJune 17, 2025Andrii Gorelik, Joao A. Paulo, Christina B. Schroeter, Melanie Lad, Abigail Shurr, Chara Mastrokalou, Samrah Siddiqi, Osamu Suyari, John Brognard, David Walter, et al.p21/CDKN1A (Cell Signaling Technology, #2947, 1:1,000, rabbit), FOSL1/FRA1 (Cell Signaling Technology, #5281, 1:1,000, rabbit), GFP (Santa Cruz, sc-9996, 1:1,000, mouse), poly/mono-ADP-ribose (Cell Signaling Technology,

(16) Cooperation between the Hippo and MAPK pathway activation drives acquired resistance to TEAD inhibitionNat CommunFebruary 18, 2025Sayantanee Paul, Thijs J. Hagenbeek, Julien Tremblay, Vasumathi Kameswaran, Christy Ong, Chad Liu, Alissa D. Guarnaccia, James A. Mondo, Peter L. Hsu, Noelyn M. Kljavin, et al.antibodies: YAP/TAZ (CST Cat. # 8418, 1:1000), pan-TEAD (CST Cat. # 13295, 1:1000), FOSL1 (CST Cat. # 5281, 1:500), CYR61 (CST Cat. # 14479, 1:1000), CTGF (CST Cat. # 86641,1:1000), GAPDH (CST Cat. # 5174, 1:2000),

(17) TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanismsSci RepFebruary 4, 2025Nicholas L. Calistri, Tiera A. Liby, Zhi Hu, Hongmei Zhang, Mark A. Dane, Sean M. Gross, Laura M. Heiserantibodies targeting the protein products of ELF3 (anti-ESE1, NBP3-32320, Novus), FOSL1 (anti-FRA1, #5281S, Cell Signaling Technology), and NFE2L2 (anti-NRF2, #20733S, Cell Signaling Technology) were used at

(18) FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancerEpigenetics & ChromatinNovember 10, 2024Qingling He, Jianyang Hu, Hao Huang, Tan Wu, Wenxiu Li, Saravanan Ramakrishnan, Yilin Pan, Kui Ming Chan, Liang Zhang, Mengsu Yang, et al.enhanced chemiluminescence substrate (Pierce). The primary antibodies used were anti-FOSL1 (CST, # 5281T), anti-TCOF1 (sigma, # HPA038237), and anti-β-actin (CST, # 3700 S). Dual-luciferase reporter assay TCOF1-E1

(19) Novel PROTAC probes targeting FOSL1 degradation to eliminate head and neck squamous cell carcinoma cancer stem cellsBioorganic chemistryOctober 1, 2024Zaman SU, Pagare PP, Huang B, Rilee G, Ma Z, Zhang Y, Li J.The following primary antibodies were used for western blot: anti-FOSL1 (Cell Signaling Technology, #5281), anti-JUN (Cell Signaling Technology, #9165) and anti-α-TUBULIN (Sigma-Aldrich, #T9026). To determine

(20) Human inborn errors of long-chain fatty acid oxidation show impaired inflammatory responses to TLR4-ligand LPSFASEB bioAdvancesSeptember 1, 2024Mosegaard S, Twayana KS, Denis SW, Kroon J, Schomakers BV, van Weeghel M, Houtkooper RH, Olsen RKJ, Holm CK.(sc‐515,202, Santa Cruz Biotechnology), anti‐JunB (#3753, CST), anti‐cJun (#9165, CST), anti‐FRA1 (#5281, CST), anti Phospho FRA1 (#3880, CST), and anti‐Vinculin (#13901, CST). Membranes were then washed three

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FRA1 (D80B4) Rabbit mAb

FRA1 (D80B4) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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FRA1 (D80B4) Rabbit mAb from Cell Signaling Technology

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