MLH1 (D38G9) Rabbit mAb 4256S from Cell Signaling Technology

Product Specs
ItemMLH1 (D38G9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number4256S
Quantity100 µl
ApplicationsW, IP
ReactivityH, Mk
TargetMLH1
HostRabbit
NCBI Gene AliasesCOCA2, FCC2, HNPCC, HNPCC2, LYNCH2, MLH-1, MMRCS1, hMLH1
ClonalityMonoclonal
NCBI Full Gene NamemutL homolog 1
Research AreaCell Cycle / Checkpoint Control
IsotypeIgG
CloneD38G9
Molecular Weight84

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) RNA/DNA-binding protein TDP43 regulates DNA mismatch repair genes with implications for genome stabilityNucleic Acids ResearchSeptember 23, 2025Vincent E Provasek, Albino Bacolla, Suganya Rangaswamy, Manohar Kodavati, Joy Mitra, Issa O Yusuf, Vikas H Malojirao, Velmarini Vasquez, Gavin W Britz, Guo-Min Li, et al.(LI-COR) and used to normalize target protein expression. Primary antibodies used: MLH1 (Cell Signaling #4256), MSH2 (Cell Signaling #2017), MSH3 (Protein Tech #22393-1-AP), MSH6 (Protein Tech #18120-1-AP), PMS2

(2) A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch RepairCancer researchFebruary 17, 2025Castro J, Daniels MH, Brennan D, Johnston B, Gotur D, Lee YT, Knockenhauer KE, Lu C, Wu J, Nayak S, et al.AB_2868586), FLAG DYKDDDDK tag (9A3; 8146, Cell Signaling Technology; RRID: AB_10950495), MLH1 (D38G9; 4256, Cell Signaling Technology; RRID: AB_10545447), and β-actin (3700, Cell Signaling Technology; RRID:

(3) RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome StabilitybioRxivNovember 13, 2024Vincent E. Provasek, Albino Bacolla, Suganya Rangaswamy, Joy Mitra, Manohar Kodavati, Issa O. Yusuf, Vikas H. Malojirao, Velmarini Vasquez, Gavin W. Britz, Guo-Min Li, et al.(LI-COR) and used to normalize target protein expression. Primary antibodies used: MLH1 (Cell Signaling #4256), MSH2 (Cell Signaling #2017), MSH3 (Protein Tech #22393-1-AP), MSH6 (Protein Tech #18120-1-AP), PMS2

(4) Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forksOncogeneAugust 1, 2024Onji H, Tate S, Sakaue T, Fujiwara K, Nakano S, Kawaida M, Onishi N, Matsumoto T, Yamagami W, Sugiyama T, et al.(cat. no. 2348, RRID: AB_331212), ATM (cat. no. 2873, RRID: AB_2062659), phospho-ATM (S1981) (cat. no. 4256, RRID: AB_2062663), MRE11 (cat. no. 4895, RRID: AB_2145100), CtIP (cat. no. 9201, RRID: AB_10828593)

(5) CDK-independent role of D-type cyclins in regulating DNA mismatch repairMolecular CellApril 4, 2024Gergely Rona, Bearach Miwatani-Minter, Qingyue Zhang, Hailey V. Goldberg, Marc A. Kerzhnerman, Jesse B. Howard, Daniele Simoneschi, Ethan Lane, John W. Hobbs, Elizabeth Sassani, et al.AB_2880562" MLH1(1:1000),Cell Signaling Technology,"Cat#3515S, RRID: AB_2145615" MLH1 (1:1000),Cell Signaling Technology,"Cat#4256S, RRID: AB_10545447" Mouse Gamma Globulin Control,ThermoFisher Scientific,"Cat#31878, RRID: AB_2532170" MSH2

(6) Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phaseiScienceMarch 17, 2023Dullovi A, Ozgencil M, Rajvee V, Tse WY, Cutillas PR, Martin SA, Hořejší Z.RRID:AB_331479 Flag (anti-DYKDDDK),Cell Signaling,Cat# 2368 RRID:AB_2217020 MLH1 (D38G9),Cell Signaling,Cat# 4256 RRID:AB_10545447 p53 (1C12),Cell Signaling,Cat# 2524 RRID:AB_331743 Phosphor-p53 (S15),Cell Signaling,Cat#

(7) Inhibition of ABL1 by tyrosine kinase inhibitors leads to a downregulation of MLH1 by Hsp70-mediated lysosomal protein degradationFrontiers in GeneticsOctober 20, 2022Hannah G. Daniels, Breanna G. Knicely, Anna Kristin Miller, Ana Thompson, Rina Plattner, Eva M. Goellnerstock was prepared in DMSO and stored at −20°C. Antibodies used in this study include MLH1 (#3515, #4256), PCNA (#2586, #13110), ABL1 (#2862), and Phospho-Tyrosine MultiMab (#8954) (Cell Signalling Inc.),

(8) Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastomaScientific reportsApril 6, 2022Ganesa S, Sule A, Sundaram RK, Bindra RS.Cell Signaling Technology pCHK1 S317 (#12302), CHK1 (#2360), MGMT (#2739), MSH2 (#2850), and MLH1 (#4256). Other antibodies used include PMS2 (ProteinTech, #66075–1-Ig), MSH3 (BD Biosciences, 611,390), MSH6

(9) Elemental characterization of crystalline silicotitanate following Hanford tank waste processingSeparation Science and TechnologyMay 24, 2021Emily L. Campbell, Amy M. Westesen, Ferdinan C. Colon, Daria Boglaienko, Tatiana G. Levitskaia, Reid A. Petersonmetals by hydrous crystalline silicotitanates. Industrial & Engineering Chemistry Research 35(11), 4246-4256, https://doi.org/10.1021/ie960073k. 22 Table 1. Summary of IX processing conditions for Cs removal

(10) The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stressCell death and differentiationMay 1, 2021Moreno R, Banerjee S, Jackson AW, Quinn J, Baillie G, Dixon JE, Dinkova-Kostova AT, Edwards J, de la Vega L.antibodies and concentrations used are as follows; DYRK2 (Abgent AP7534a) at 1:200 and HSF1 (Cell Signalling 4256) at 1:500. Staining was visualised using ImmPRESSTM and ImmPACTTM DAB, (both Vector Labs). Tissue was

(11) Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cellsCell death & diseaseJuly 24, 2020Zhai B, Li Y, Kotapalli SS, Bacha J, Brown D, Steinø A, Daugaard M.(2661, Cell Signaling Technology); BRCA1 (NB100–404, Novus Biologicals, Centennial, CO, USA); MLH1 (4256, Cell Signaling Technology); MSH2 (2017, Cell Signaling Technology); and GAPDH (5174, Cell Signaling Technology

(12) MLH1 deficiency leads to deregulated mitochondrial metabolismCell Death & DiseaseNovember 1, 2019Sukaina Rashid et al.non-fat dried milk, membranes were incubated overnight at 4 °C in primary antibody, including anti-MLH1 (#4256, Cell Signalling), anti-Total OXPHOS Human Antibody Cocktail (Ab110411, Abcam), anti-NRF2 (Ab137550,

(13) Effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cellsOncology reportsJune 1, 2019Zhao L, Shou H, Chen L, Gao W, Fang C, Zhang P.1:1,000; cat. no. 2527), p16 (dilution 1:1,000; cat. no. 80772), hMLH1 (dilution 1:1,000; cat. no. 4256), DNMT1 (dilution 1:1,000; cat. no. 5032), DNMT3a (dilution 1:1,000; cat. no. 32578), DNMT3b (dilution

(14) LC‑MS/MS metabolome analysis detects the changes in the lipid metabolic profiles of dMMR and pMMR cellsOncology ReportsJune 20, 2018Wen Peng et al.The relative quantities of each protein were analyzed by probing the membranes with MLH1 (cat. no. 4256s), MSH2 (cat. no. 2017s), MLH6 (cat. no. 5424s) and PMS2 (cat. no. 2455s) antibodies (dilution 1:1,000;

(15) Drug-Repositioning Screens Identify Triamterene as a Selective Drug for the Treatment of DNA Mismatch Repair Deficient CellsClinical Cancer ResearchJune 1, 2017Delphine Guillotin, Philip Austin, Rumena Begum, Marta O. Freitas, Ashirwad Merve, Tim Brend, Susan Short, Silvia Marino, Sarah A. Martinand immunoblotted using the following antibodies: anti-MSH6 (#5424), anti-MSH2 (#2017), anti-MLH1 (#4256), anti-thymidylate synthase (#9045), β-Actin (#4970), purchased from Cell Signaling. The following antibodies

(16) Cellular response to alkylating agent MNNG is impaired in STAT1-deficients cellsJournal of cellular and molecular medicineOctober 1, 2016Ah-Koon L, Lesage D, Lemadre E, Souissi I, Fagard R, Varin-Blank N, Fabre EE, Schischmanoff O.

(17) U12, a UDCA derivative, acts as an anti-hepatoma drug lead and inhibits the mTOR/S6K1 and cyclin/CDK complex pathwaysPloS oneJanuary 1, 2014Xu Y, Luo Q, Lin T, Zeng Z, Wang G, Zeng D, Ding R, Sun C, Zhang XK, Chen H.p27 (2552P) were obtained from Cell Signaling (Beverly, MA, U.S.). Primary antibodies for Cdc25A (sc-4256) and LaminA/C (sc-7293) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, U.S.). Anti-β-actin

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MLH1 (D38G9) Rabbit mAb

MLH1 (D38G9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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MLH1 (D38G9) Rabbit mAb from Cell Signaling Technology

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