Fig 1: Single-cell sequencing reveals changes in T cell states in SFTS patients(A) The UMAP plot displays 88,377 cells from three groups, colored by nine major cell types.(B) Proportion of major cell types in different groups. HC, healthy control; SF.Sur, survivors of SFTS patients; SF.Dea, deceased patients with SFTS.(C) The UMAP plot displays T cells colored by the 10 T cell subsets.(D) The proportions of T cell subsets in different groups.(E) The CD4+ T cell differentiation trajectory plot based on Monocle2, separated by groups, with cells colored by T cell subtypes (left). The CD4+ T cell trajectory plot is colored according to pseudotime (right).(F) The CD8+ T cell differentiation trajectory plot based on Monocle2, separated by groups, with cells colored by T cell subtypes (left). The CD8+ T cell trajectory plot is colored according to pseudotime (right).(G) Heatmap showing expression of the immune checkpoints of T cell subsets.(H) Identify and visualize the conserved and context-specific signaling pathways between SF.Sur group and SF.Dea group. See also Figures S1 and S2.