Anti-Kir2.1/KCNJ2 Antibody APC-026 from Alomone Labs, Ltd.

Product Specs
ItemAnti-Kir2.1/KCNJ2 Antibody
CompanyAlomone Labs, Ltd.
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAPC-026
Brand/TrademarkAlomone Labs Ltd
ApplicationsICC, IF, IFC, IHC, IP, WB
Quantity1 X 25 mcl, 1 X 50 mcl, 1 X 0.2 ml
Conjugate/TagUnconjugated
FormatReconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3., Lyophilized Powder
ReactivityHuman (Tested);Mouse (Tested);Rat (Tested)
ClonalityPolyclonal
HostRabbit
Antibody TypePrimary
Concentration06 mg/ml
PurityAffinity purified on immobilized antigen
IsotypeIgG
ImmunogenSynthetic peptide
Domain/Region/TerminusIntracellular, C-terminal domain
Gene NameKCNJ2
TargetKir2.1 (KCNJ2) Channel
ValidationAs per applications, See images, contact for clarifications
pH RangepH 7.4

Specifications/Features

starting price for North American orders, for exact pricing view product page

Sequence

(C)NGVPEST STDTPPDIDL HN, corresponding to amino acid residues 392-410 of human Kir2.1

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Alomone Labs, Ltd.

PO Box 4287

Jerusalem 91042

Israel

Phone: +972-2-587-2202
+972-2-587-1101

Company Profile

Website: http://www.alomone.com/

(1) A critical period of prehearing spontaneous Ca2+ spiking is required for hair‐bundle maintenance in inner hair cellsThe EMBO JournalFebruary 15, 2023Adam J Carlton, Jing‐Yi Jeng, Fiorella C Grandi, Francesca De Faveri, Federico Ceriani, Lara De Tomasi, Anna Underhill, Stuart L Johnson, Kevin P Legan, Corné J Kros, et al.gift from Dr. Thomas Friedman, NIH, USA) mouse‐IgG1 anti‐Kir2.1 channel (1:100, Alomone Lab, Israel, APC026); mouse IgG1 anti‐CtBP2 (1:200, Biosciences, #612044) and mouse IgG2a anti‐GluR2 (1:200, Millipore,

(2) KIR channel regulation of electrical conduction along cerebrovascular endothelium: Enhanced modulation during Alzheimer's diseaseMicrocirculationJanuary 6, 2023Md A. Hakim, Erik J. Behringerprimary antibody for Cx37 (42-4400, ThermoFisher), Cx40 (36-4900, Invitrogen, ThermoFisher), or KIR2.1 (APC-026; Alomone Labs, Jerusalem, Israel). The tube was washed (3 × 5 minutes) in PBS and then incubated with

(3) Genetic ablation of smooth muscle K_IR2.1 is inconsequential to the function of mouse cerebral arteriesJournal of Cerebral Blood Flow & MetabolismSeptember 1, 2022Paulina M Kowalewska et al.was used to block cells for one hour (21 °C). Rabbit polyclonal primary antibodies against KIR2.1 (APC-026, 1:200; Alomone) and KIR2.2 (APC-042, 1:200; Alomone) were diluted in quench solution and applied to

(4) Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channelsCardiovascular researchFebruary 21, 2022Simon-Chica A, Fernández MC, Wülfers EM, Lother A, Hilgendorf I, Seemann G, Ravens U, Kohl P, Schneider-Warme F.

(5) Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarctionThe Journal of clinical investigationSeptember 15, 2021Liu M, Liu H, Parthiban P, Kang GJ, Shi G, Feng F, Zhou A, Gu L, Karnopp C, Tolkacheva EG, et al.

(6) Impaired cytoplasmic domain interactions cause co-assembly defect and loss of function in the p.Glu293Lys KNCJ2 variant isolated from an Andersen–Tawil syndrome patientCardiovascular ResearchJuly 7, 2021Szilvia Déri et al.1:400, Life Technologies, Carlsbad, CA USA), Kir2.1 was labelled by the Anti-Kir2.1 primary antibody (APC026, 1:100, Alomone Labs, Jerusalem, Israel) recognizing an epitope on the cytoplasmic C-terminus of Kir2.1

(7) Synaptic Scaffolds, Ion Channels and Polyamines in Mouse Photoreceptor Synapses: Anatomy of a Signaling ComplexFrontiers in cellular neuroscienceJanuary 1, 2021Vila A, Shihabeddin E, Zhang Z, Santhanam A, Ribelayga CP, O'Brien J.AB_1587072,1:200 Kir2.1,Rb,Peptide NGVPESTSTDTPPDIDLHN from C-terminus of human Kir2.1 (aa392–410),"Alomone, Jerusalem, Israel",APC-026 AB_2040107,1:400 Kir2.1,GP,Peptide NGVPESTSTDTPPDIDLHN from C-terminus of human Kir2.1 (aa392–410),"Alomone,

(8) Fibroblast Growth Factor 21 Ameliorates Na(V)1.5 and Kir2.1 Channel Dysregulation in Human AC16 CardiomyocytesFrontiers in pharmacologyJanuary 1, 2021Li J, Li Y, Liu Y, Yu H, Xu N, Huang D, Xue Y, Li S, Chen H, Liu J, et al.including rabbit anti-NaV1.5 antibody (ASC-005, Alomone Labs, Israel, 1: 200), rabbit anti-Kir2.1 antibody (APC-026, Alomone Labs, Israel, 1: 200) followed by incubation with the corresponding secondary antibody for

(9) Three-Week-Old Rabbit Ventricular Cardiomyocytes as a Novel System to Study Cardiac Excitation and EC CouplingFrontiers in physiologyJanuary 1, 2021Kabakov AY, Sengun E, Lu Y, Roder K, Bronk P, Baggett B, Turan NN, Moshal KS, Koren G.anti-human Ether-à-go-go-Related Gene (HERG) (Alomone; APC-062; 1:1,000); rabbit anti-Kir2.1 (Alomone; APC-026; 1:1,000); rabbit anti-Kv4.3 (Alomone; APC-017; 1:1,000); rabbit anti-Nav1.5 (Alomone; ASC-005; 1:1,000);

(10) Up-regulation of miR-195 contributes to cardiac hypertrophy-induced arrhythmia by targeting calcium and potassium channelsJournal of cellular and molecular medicineJuly 1, 2020Xuan L, Zhu Y, Liu Y, Yang H, Wang S, Li Q, Yang C, Jiao L, Zhang Y, Yang B, et al.membrane. The primary anti‐Cavβ1 (Abcam, Cat# ab85020) and anti‐Kir2.1 antibody (Alomone Labs, Cat# APC‐026), and anti‐Kv4.3 antibody (Alomone Labs, Cat#APC‐017) were used. GAPDH (Beijing, China, Cat#TA‐08) was

(11) Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagyeLifeJanuary 8, 2020Lieberman OJ, Frier MD, McGuirt AF, Griffey CJ, Rafikian E, Yang M, Yamamoto A, Borgkvist A, Santini E, Sulzer D.1D4B,See Table S3 in Supplementary file 1 Antibody,Rabbit anti Kir2.1 polyclonal,Alomone Labs,Cat # APC-026,See Table S3 in Supplementary file 1 Antibody,Mouse anti ubiquitin antibody monoclonal VU-1,LifeSensors,Cat

(12) Altering integrin engagement regulates membrane localization of K_ir2.1 channelsJournal of cell scienceSeptember 2, 2019Sengupta S, Rothenberg KE, Li H, Hoffman BD, Bursac N.

(13) Pressure-dependent modulation of inward-rectifying K⁺ channels: implications for cation homeostasis and K⁺ dynamics in glaucomaAmerican journal of physiology. Cell physiologyAugust 1, 2019Fischer RA, Roux AL, Wareham LK, Sappington RM.

(14) An assessment of K_IR channel function in human cerebral arteriesAmerican journal of physiology. Heart and circulatory physiologyApril 1, 2019Sancho M, Gao Y, Hald BO, Yin H, Boulton M, Steven DA, MacDougall KW, Parrent AG, Pickering JG, Welsh DG.20), and subsequently incubated overnight (4°C, humidified chamber) with anti-KIR primary antibody (APC-026, Alomone) diluted (1:100) in quench solution. The next morning, sections were washed in PBS-0.2% Tween

(15) Nucleoporin 107 facilitates the nuclear export of Scn5a mRNA to regulate cardiac bioelectricityJournal of cellular and molecular medicineFebruary 1, 2019Guan Y, Gao X, Tang Q, Huang L, Gao S, Yu S, Huang J, Li J, Zhou D, Zhang Y, et al.

(16) Hypoxic stress upregulates K_ir2.1 expression by a pathway including hypoxic-inducible factor-1α and dynamin2 in brain capillary endothelial cellsAmerican journal of physiology. Cell physiologyAugust 1, 2018Yamamura H, Suzuki Y, Yamamura H, Asai K, Giles W, Imaizumi Y.to nitrocellulose membrane (BioRad, Hercules, CA). The blots were incubated with the anti-Kir2.1 antibody (APC-026, 1:200 dilution, Alomone Laboratory, Jerusalem, Israel), the anti-dynamin2 antibody (C-18, 1:200 dilution,

(17) Electrical and histological remodeling of the pulmonary vein in 2K1C hypertensive rats: Indication of initiation and maintenance of atrial fibrillationAnatolian journal of cardiologyMarch 1, 2018Xia PP, Li LJ, Qi RD, Shi JJ, Ju WZ, Chen ML.

(18) A Singular Role of I(K1) Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by I(K1) -Induced Activation of Pacemaker CurrentStem cell reviews and reportsOctober 1, 2017Sun Y, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita KR, Deschênes I, Li RA, Fu JD.

(19) Decreased inward rectifier potassium current I_K1 in dystrophin-deficient ventricular cardiomyocytesChannels (Austin, Tex.)March 4, 2017Rubi L, Koenig X, Kubista H, Todt H, Hilber K.incubated over night with the primary antibody (anti-Kir2.1 polyclonal antibody produced in rabbit; APC-026, Alomone Labs, 1:1000 in 2% BSA) at 4°C. On the next day, after 3 PBS washing steps, the membrane was

(20) Activation of group I metabotropic glutamate receptors regulates the excitability of rat retinal ganglion cells by suppressing Kir and I _hBrain structure & functionMarch 1, 2017Li Q, Cui P, Miao Y, Gao F, Li XY, Qian WJ, Jiang SX, Wu N, Sun XH, Wang Z.

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